Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Krka

Darunavir Krka 400 mg film-coated tablets Darunavir Krka 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 21–22

HOS-225735 · Präparat HOS-217490

21  treatment of pulmonary arterial hypertension with boosted darunavir is not recommended. PROTON PUMP INHIBITORS # Omeprazole darunavir AUC ↔ Boosted darunavir can be co- # 20 mg once daily darunavir Cmin ↔ administered with proton pump # darunavir Cmax ↔ inhibitors without dose adjustments. SEDATIVES/HYPNOTICS Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is recommended Clorazepate extensively metabolised by CYP3A. Co- when co-administering boosted Diazepam administration with boosted darunavir may darunavir with these Estazolam cause a large increase in the concentration sedatives/hypnotics and a lower dose Flurazepam of these medicines. of the sedatives/hypnotics should be Midazolam (parenteral) considered. Zolpidem If parenteral midazolam is co-administered If parenteral midazolam is co- with boosted darunavir it may cause a administered with boosted darunavir, large increase in the concentration of this it should be done in an intensive care benzodiazepine. Data from concomitant unit (ICU) or similar setting, which use of parenteral midazolam with other ensures close clinical monitoring and protease inhibitors suggest a possible 3- appropriate medical management in 4 fold increase in midazolam plasma case of respiratory depression and/or levels. prolonged sedation. Dose adjustment for midazolam should be considered, especially if more than a single dose of midazolam is administered.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): protease (HOS-085623) estazolam (HOS-086165) clorazepate (HOS-086164) diazepam (HOS-085904) zolpidem (HOS-086327) buspirone (HOS-086325) flurazepam (HOS-086166) midazolam (HOS-086167) omeprazole (HOS-085912)