Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Efavirenz/Emtricitabine/Tenofovir disoproxil Krka

Efavirenz/Emtricitabine/Tenofovir disoproxil Krka 600 mg/200 mg/245 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 21

HOS-225910 · Präparat HOS-217504

Co-administration of higher doses of either efavirenz or carbamazepine has not been studied. Carbamazepine/Emtricitabine Interaction not studied. Carbamazepine/Tenofovir Interaction not studied. disoproxil Phenytoin, Phenobarbital, and Interaction not studied with efavirenz, When other anticonvulsants that are emtricitabine, or tenofovir disoproxil. There efavirenz/emtricitabine/tenofovir substrates of CYP isozymes is a potential for reduction or increase in the disoproxil is coadministered with plasma concentrations of phenytoin, an anticonvulsant that is a phenobarbital and other anticonvulsants that substrate of CYP isozymes, are substrates of CYP isozymes with periodic monitoring of efavirenz. anticonvulsant levels should be conducted. Valproic acid/Efavirenz No clinically significant effect on efavirenz Efavirenz/emtricitabine/tenofovir (250 mg b.i.d./600 mg q.d.) pharmacokinetics. Limited data suggest disoproxil and valproic acid can there is no clinically significant effect on be co-administered without dose valproic acid pharmacokinetics. adjustment. Patients should be Valproic acid/Emtricitabine Interaction not studied. monitored for seizure control. Valproic acid/Tenofovir disoproxil Interaction not studied. Vigabatrin/Efavirenz Interaction not studied. Clinically significant Efavirenz/emtricitabine/tenofovir Gabapentin/Efavirenz interactions are not expected since disoproxil and vigabatrin or vigabatrin and gabapentin are exclusively gabapentin can be coadministered eliminated unchanged in the urine and are without dose adjustment. unlikely to compete for the same metabolic enzymes and elimination pathways as efavirenz. Vigabatrin/Emtricitabine Interaction not studied. Gabapentin/Emtricitabine Vigabatrin/Tenofovir disoproxil Interaction not studied. Gabapentin/Tenofovir disoproxil ANTICOAGULANTS Warfarin/Efavirenz Interaction not studied. Plasma Dose adjustment of warfarin or Acenocoumarol/Efavirenz concentrations and effects of warfarin or acenocoumarol may be required acenocoumarol are potentially increased or when co-administered with decreased by efavirenz. efavirenz/emtricitabine/tenofovir disoproxil. ANTIDEPRESSANTS Selective Serotonin Reuptake Inhibitors (SSRIs) Sertraline/Efavirenz Sertraline: When co-administered with (50 mg q.d./600 mg q.d.) AUC: ↓ 39% (↓ 27 to ↓ 50) efavirenz/emtricitabine/tenofovir

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) vigabatrin (HOS-115599) phenobarbital (HOS-085617) valproic acid (HOS-088515) carbamazepine (HOS-085618) gabapentin (HOS-090745) serotonin (HOS-085477) sertraline (HOS-086247) acenocoumarol (HOS-109456) phenytoin (HOS-084531) warfarin (HOS-085950)