Wechselwirkungen · Lacosamide Accord
Lacosamide Accord 50 mg film-coated tablets Lacosamide Accord 100 mg film-coated tablets Lacosamide Accord 150 mg film-coated tablets Lacosamide Accord 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-226812 · Präparat HOS-217674
In interaction studies lacosamide did not significantly affect the plasma concentrations of carbamazepine and valproic acid. Lacosamide plasma concentrations were not affected by carbamazepine and by valproic acid. Population pharmacokinetic analyses in different age groups estimated that concomitant treatment with other antiepileptic medicinal products known to be enzyme inducers (carbamazepine, phenytoin, phenobarbital, in various doses) decreased the overall systemic exposure of lacosamide by 25 % in adults and 17 % in paediatric patients.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) valproic acid (HOS-088515) carbamazepine (HOS-085618) phenytoin (HOS-084531)
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Version 2025-05-28T09:34:00Z · SHA-256 560654e794b51f1f98ec5faec2a82087182d1fa2778f435c8ed6f6048cc03957 · Passage dc2cb23905ab8a1d7b008c0bccd68afbcae377b3560bc6b4b4289a110c3b1d4c · Zeichen 2243–2791 im Abschnitt