Wechselwirkungen · Lacosamide Accord
Lacosamide Accord 10 mg/ml solution for infusion · Abschnitt 4.5 · PDF-Seite 45
HOS-226875 · Präparat HOS-217674
Interaction studies showed that lacosamide had no effect on the pharmacokinetics of digoxin. There was no clinically relevant interaction between lacosamide and metformin. Co-administration of warfarin with lacosamide does not result in a clinically relevant change in the pharmacokinetics and pharmacodynamics of warfarin. Although no pharmacokinetic data on the interaction of lacosamide with alcohol are available, a pharmacodynamic effect cannot be excluded. Lacosamide has a low protein binding of less than 15 %. Therefore, clinically relevant interactions with other medicinal products through competition for protein binding sites are considered unlikely.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): digoxin (HOS-086172) warfarin (HOS-085950) metformin (HOS-091032)
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Version 2025-05-28T09:34:00Z · SHA-256 560654e794b51f1f98ec5faec2a82087182d1fa2778f435c8ed6f6048cc03957 · Passage d024662a4410b42e718d28376aa2e833bc9bf38b3f62e59b1be949c46e140da1 · Zeichen 3123–3786 im Abschnitt