Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Apexelsin

Apexelsin 5 mg/ml powder for dispersion for infusion. · Abschnitt 4.8 · PDF-Seite 11–12

HOS-299068 · Präparat HOS-288899

11  Monotherapy (N = 789) Combination Combination therapy with therapy with gemcitabine carboplatin (N = 421) (N = 514) Eye disorders Vision blurred, lacrimation Lacrimation Vision blurred increased, dry eye, increased Common: keratoconjunctivitis sicca, madarosis Reduced visual acuity, Cystoid macular abnormal vision, eye oedema irritation, eye pain, Uncommon: conjunctivitis, visual disturbance, eye pruritus, keratitis Rare: Cystoid macular oedema1 Ear and labyrinth disorders Common: Vertigo Uncommon: Tinnitus, ear pain Cardiac disorders Arrhythmia, tachycardia, Cardiac failure Common: supraventricular tachycardia congestive, tachycardia Cardiac arrest, cardiac failure congestive, left ventricular Rare: dysfunction, atrioventricular block1, bradycardia Vascular disorders Hypertension, lymphoedema, Hypotension, Hypotension, Common: flushing, hot flushes hypertension hypertension Hypotension, orthostatic Flushing Flushing Uncommon: hypotension, peripheral coldness Rare: Thrombosis Respiratory, thoracic and mediastinal disorders Dyspnoea, epistaxis, Dyspnoea Very common: cough Interstitial pneumonitis2, Pneumonitis, nasal Haemoptysis, dyspnoea, epistaxis, congestion epistaxis, cough Common: pharyngolaryngeal pain, cough, rhinitis, rhinorrhoea Pulmonary emboli, Dry throat, nasal Pneumonitis pulmonary dryness thromboembolism, pleural effusion, exertional dyspnoea, sinus congestion, Uncommon: decreased breath sounds, productive cough, allergic rhinitis, hoarseness, nasal congestion, nasal dryness, wheezing Not known: Vocal cord paresis1

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