Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Afinitor
Afinitor 2.5 mg tablets Afinitor 5 mg tablets Afinitor 10 mg tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-210305 · Präparat HOS-154501
Active substance by Interaction – Change in Recommendations concerning
interaction Everolimus AUC/Cmax co-administration
Geometric mean ratio
(observed range)
Potent CYP3A4/PgP inhibitors
Ketoconazole AUC ↑15.3-fold Concomitant treatment of Afinitor
(range 11.2-22.5) and potent inhibitors is not
Cmax ↑4.1-fold recommended.
(range 2.6-7.0)
Itraconazole, posaconazole, Not studied. Large increase in
voriconazole everolimus concentration is
Telithromycin, expected.
clarithromycin
Nefazodone
Ritonavir, atazanavir,
saquinavir, darunavir,
indinavir, nelfinavir
Moderate CYP3A4/PgP inhibitors
Erythromycin AUC ↑4.4-fold Use caution when
(range 2.0-12.6) co-administration of moderate
Cmax ↑2.0-fold CYP3A4 inhibitors or PgP
(range 0.9-3.5) inhibitors cannot be avoided. If
Imatinib AUC ↑ 3.7-fold patients require co-administration
Cmax ↑ 2.2-fold of a moderate CYP3A4 or PgP
Verapamil AUC ↑3.5-fold inhibitor, dose reduction to 5 mg
(range 2.2-6.3) daily or 2.5 mg daily may be
Cmax ↑2.3-fold considered. However, there are no
(range1.3-3.8) clinical data with this dose
Ciclosporin oral AUC ↑2.7-fold adjustment. Due to between
(range 1.5-4.7) subject variability the
Cmax ↑1.8-fold recommended dose adjustments
(range 1.3-2.6) may not be optimal in all
Cannabidiol (PgP inhibitor) AUC ↑2.5-fold individuals, therefore close
Cmax ↑2.5-fold monitoring of side effects is
Fluconazole Not studied. Increased exposure recommended (see sections 4.2 and
Diltiazem expected. 4.4). If the moderate inhibitor is
Dronedarone Not studied. Increased exposure discontinued, consider a washout
expected. period of at least 2 to 3 days
Amprenavir, fosamprenavir Not studied. Increased exposure (average elimination time for most
expected. commonly used moderate
inhibitors) before the Afinitor dose
is returned to the dose used prior to
initiation of the co-administration.
Grapefruit juice or other Not studied. Increased exposure Combination should be avoided.
food affecting CYP3A4/PgP expected (the effect varies
widely).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) diltiazem (HOS-086288) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) dronedarone (HOS-086144) ketoconazole (HOS-084513) grapefruit juice (HOS-088787) cannabidiol (HOS-090609) imatinib (HOS-110212) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) fluconazole (HOS-087945) clarithromycin (HOS-084517) erythromycin (HOS-084514) amprenavir (HOS-086183) darunavir (HOS-086181) fosamprenavir (HOS-086182) ritonavir (HOS-084521) posaconazole (HOS-085622) verapamil (HOS-090602)
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Version 2025-11-20T11:21:00Z · SHA-256 678fc33837cd44d2e9320c5c80ffc02496b10803d7810e1b4f6e2d8e517263a0 · Passage 98d9f664e41c1a110308717f9cdec97f696053564a7a56a6d0f4d257ec0e0700 · Zeichen 1007–4534 im Abschnitt
Wechselwirkungen · Tepadina
TEPADINA 15 mg powder for concentrate for solution for infusion TEPADINA 100 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 7
HOS-210368 · Präparat HOS-154509
Thiotepa appears to be metabolised via CYP2B6 and CYP3A4. Co-administration with inhibitors of
CYP2B6 (for example clopidogrel and ticlopidine) or CYP3A4 (for example azole antifungals,
macrolides like erythromycin, clarithromycin, telithromycin, and protease inhibitors) may increase the
plasma concentrations of thiotepa and potentially decrease the concentrations of the active metabolite
TEPA. Co-administration of inducers of cytochrome P450 (such as rifampicin, carbamazepine,
phenobarbital) may increase the metabolism of thiotepa leading to increased plasma concentrations of
the active metabolite. Therefore, during the concomitant use of thiotepa and these medicinal products,
patients should be carefully monitored clinically.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): protease (HOS-085623) phenobarbital (HOS-085617) carbamazepine (HOS-085618) telithromycin (HOS-084523) clopidogrel (HOS-087927) clarithromycin (HOS-084517) erythromycin (HOS-084514) ticlopidine (HOS-087946)
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Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 935ef43576517d09bc14a3c14eab20625efebd8312dd982b5d7f92f94cda8e10 · Zeichen 253–990 im Abschnitt
Wechselwirkungen · Tepadina
TEPADINA 200 mg powder and solvent for solution for infusion TEPADINA 400 mg powder and solvent for solution for infusion · Abschnitt 4.5 · PDF-Seite 24
HOS-210414 · Präparat HOS-154509
Thiotepa appears to be metabolised via CYP2B6 and CYP3A4. Co-administration with inhibitors of
CYP2B6 (for example clopidogrel and ticlopidine) or CYP3A4 (for example azole antifungals,
macrolides like erythromycin, clarithromycin, telithromycin, and protease inhibitors) may increase the
plasma concentrations of thiotepa and potentially decrease the concentrations of the active metabolite
TEPA. Co-administration of inducers of cytochrome P450 (such as rifampicin, carbamazepine,
phenobarbital) may increase the metabolism of thiotepa leading to increased plasma concentrations of
the active metabolite. Therefore, during the concomitant use of thiotepa and these medicinal products,
patients should be carefully monitored clinically.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): protease (HOS-085623) phenobarbital (HOS-085617) carbamazepine (HOS-085618) telithromycin (HOS-084523) clopidogrel (HOS-087927) clarithromycin (HOS-084517) erythromycin (HOS-084514) ticlopidine (HOS-087946)
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Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 935ef43576517d09bc14a3c14eab20625efebd8312dd982b5d7f92f94cda8e10 · Zeichen 253–990 im Abschnitt
Wechselwirkungen · Votrient
Votrient 200 mg film-coated tablets Votrient 400 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-122558 · Präparat HOS-095539
Co-administration of pazopanib with other strong inhibitors of the CYP3A4 family (e.g. itraconazole,
clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin,
voriconazole) may increase pazopanib concentrations. Grapefruit juice contains an inhibitor of
CYP3A4 and may also increase plasma concentrations of pazopanib.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) grapefruit juice (HOS-088787) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
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Version 2025-10-28T11:24:00Z · SHA-256 38e00132fe316301c56a9c9a4f9247483c54b55dd743bedaab120a272380aaff · Passage b42c756e6e6a2fa13f5954df2519e90091d64aef8b3e00883e77607a019cd19b · Zeichen 1494–1855 im Abschnitt
Wechselwirkungen · Jevtana
JEVTANA 60 mg concentrate and solvent for solution for infusion. · Abschnitt 4.5 · PDF-Seite 6–7
HOS-124033 · Präparat HOS-095771
6
Repeated administration of ketoconazole (400 mg once daily), a strong CYP3A inhibitor, resulted in a
20% decrease in cabazitaxel clearance corresponding to a 25% increase in AUC. Therefore
concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole,
clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole)
should be avoided as an increase of plasma concentrations of cabazitaxel may occur (see sections 4.2
and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-09-30T13:04:00Z · SHA-256 4c1eff0507207d5beb179217fec464186ac3bc1330fa052cff48922b617d3c37 · Passage 6ce0e854043e4c44191bafd62a79322441f6096508dea8df3222ab048975ffeb · Zeichen 184–678 im Abschnitt
Wechselwirkungen · Plenadren
Plenadren 5 mg modified-release tablets Plenadren 20 mg modified-release tablets · Abschnitt 4.5 · PDF-Seite 5
HOS-213704 · Präparat HOS-155174
Potent CYP 3A4 inhibitors such as ketoconazole, itraconazole, posaconazole, voriconazole
erythromycin, telithromycin, clarithromycin, ritonavir and grapefruit juice can inhibit the metabolism
of hydrocortisone, and thus increase blood levels. During long-term prophylactic treatment with any of
the antibiotics, adjustment of the hydrocortisone dosage should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ketoconazole (HOS-084513) grapefruit juice (HOS-088787) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) clarithromycin (HOS-084517) erythromycin (HOS-084514) ritonavir (HOS-084521) posaconazole (HOS-085622)
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Version 2022-12-06T10:00:00Z · SHA-256 53473ee0edc582bcd44e3accf6dc87633e3875e631a072bc9c72cbe175c453a7 · Passage 403f8768384f1c2094c8e2e9d1d2c8c4e74f8093886deec2b6b7b457679c2e25 · Zeichen 552–925 im Abschnitt
Wechselwirkungen · Gilenya
Gilenya 0.25 mg hard capsules Gilenya 0.5 mg hard capsules · Abschnitt 4.5 · PDF-Seite 13
HOS-124783 · Präparat HOS-095937
Fingolimod is metabolised mainly by CYP4F2. Other enzymes like CYP3A4 may also contribute to
its metabolism, notably in the case of strong induction of CYP3A4. Potent inhibitors of transporter
proteins are not expected to influence fingolimod disposition. Co-administration of fingolimod with
ketoconazole resulted in a 1.7-fold increase in fingolimod and fingolimod phosphate exposure (AUC)
by inhibition of CYP4F2. Caution should be exercised with substances that may inhibit CYP3A4
(protease inhibitors, azole antifungals, some macrolides such as clarithromycin or telithromycin).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): protease (HOS-085623) ketoconazole (HOS-084513) telithromycin (HOS-084523) clarithromycin (HOS-084517)
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Version 2026-09-29T11:20:00Z · SHA-256 14535f3eca03884aa2cdac6745c9ca3473c671171833be03bbc450e2d1533438 · Passage 74ea7c608c0ac51219c123ce9f749a0a9a39e34ff7564965821d7a9d2431bbd5 · Zeichen 1969–2552 im Abschnitt
Wechselwirkungen · Votubia
Votubia 2.5 mg tablets Votubia 5 mg tablets Votubia 10 mg tablets · Abschnitt 4.5 · PDF-Seite 11
HOS-214256 · Präparat HOS-155312
Active substance by Interaction – Change in Recommendations concerning
interaction Everolimus AUC/Cmax co-administration
Geometric mean ratio
(observed range)
Potent CYP3A4/PgP inhibitors
Ketoconazole AUC ↑15.3-fold Concomitant treatment of Votubia
(range 11.2-22.5) and potent inhibitors is not
Cmax ↑4.1-fold recommended.
(range 2.6-7.0)
Itraconazole, posaconazole, Not studied. Large increase in
voriconazole everolimus concentration is
Telithromycin, expected.
clarithromycin
Nefazodone
Ritonavir, atazanavir,
saquinavir, darunavir,
indinavir, nelfinavir
Moderate CYP3A4/PgP inhibitors
Erythromycin AUC ↑4.4-fold Use caution when co-administration
(range 2.0-12.6) of moderate CYP3A4 inhibitors or
Cmax ↑2.0-fold PgP inhibitors cannot be avoided.
(range 0.9-3.5)
Imatinib AUC ↑ 3.7-fold For patients with renal
Cmax ↑ 2.2-fold angiomyolipoma associated with
Verapamil AUC ↑3.5-fold TSC:
(range 2.2-6.3) If patients require co-administration
Cmax ↑2.3-fold of a moderate CYP3A4 or PgP
(range1.3-3.8) inhibitor, dose reduction to 5 mg or
Ciclosporin oral AUC ↑2.7-fold 2.5 mg daily may be considered.
(range 1.5-4.7) However, there are no clinical data
Cmax ↑1.8-fold with this dose adjustment. Due to
(range 1.3-2.6) between subject variability the
Cannabidiol (PgP inhibitor) AUC ↑2.5-fold recommended dose adjustments may
Cmax ↑2.5-fold not be optimal in all individuals,
Fluconazole Not studied. Increased exposure therefore close monitoring of side
Diltiazem expected. effects is recommended. If the
Dronedarone Not studied. Increased exposure moderate inhibitor is discontinued,
expected. consider a washout period of at least
Amprenavir, fosamprenavir Not studied. Increased exposure 2 to 3 days (average elimination time
expected. for most commonly used moderate
inhibitors) before the Votubia dose is
returned to the dose used prior to
initiation of the co-administration
(see also Therapeutic drug
monitoring in section 4.2).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) diltiazem (HOS-086288) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) dronedarone (HOS-086144) ketoconazole (HOS-084513) cannabidiol (HOS-090609) imatinib (HOS-110212) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) fluconazole (HOS-087945) clarithromycin (HOS-084517) erythromycin (HOS-084514) amprenavir (HOS-086183) darunavir (HOS-086181) fosamprenavir (HOS-086182) ritonavir (HOS-084521) posaconazole (HOS-085622) verapamil (HOS-090602)
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Version 2025-11-20T17:40:00Z · SHA-256 252b066ec590fdab1f3eb7eccacdb5c7e91ec79421c970096d1b5261820faba4 · Passage 874bc02290752e0fb541064d49638c0e5fad0c860b7d55032749ccc1bff1dcda · Zeichen 1008–4464 im Abschnitt
Wechselwirkungen · Votubia
Votubia 1 mg dispersible tablets Votubia 2 mg dispersible tablets Votubia 3 mg dispersible tablets Votubia 5 mg dispersible tablets · Abschnitt 4.5 · PDF-Seite 38
HOS-214306 · Präparat HOS-155312
Active substance by Interaction – Change in Recommendations concerning
interaction Everolimus AUC/Cmax co-administration
Geometric mean ratio
(observed range)
Potent CYP3A4/PgP inhibitors
Ketoconazole AUC ↑15.3-fold Concomitant treatment of Votubia
(range 11.2-22.5) and potent inhibitors is not
Cmax ↑4.1-fold recommended.
(range 2.6-7.0)
Itraconazole, posaconazole, Not studied. Large increase in
voriconazole everolimus concentration is
Telithromycin, expected.
clarithromycin
Nefazodone
Ritonavir, atazanavir,
saquinavir, darunavir,
indinavir, nelfinavir
Moderate CYP3A4/PgP inhibitors
Erythromycin AUC ↑4.4-fold Use caution when co-administration
(range 2.0-12.6) of moderate CYP3A4 inhibitors or
Cmax ↑2.0-fold PgP inhibitors cannot be avoided.
(range 0.9-3.5)
Imatinib AUC ↑ 3.7-fold If patients require co-administration
Cmax ↑ 2.2-fold of a moderate CYP3A4 or PgP
Verapamil AUC ↑3.5-fold inhibitor, reduce the daily dose by
(range 2.2-6.3) approximately 50%. Further dose
Cmax ↑2.3-fold reduction may be required to manage
(range1.3-3.8) adverse reactions (see sections 4.2
Ciclosporin oral AUC ↑2.7-fold and 4.4). Everolimus trough
(range 1.5-4.7) concentrations should be assessed at
Cmax ↑1.8-fold least 1 week after the addition of a
(range 1.3-2.6) moderate CYP3A4 or PgP inhibitor.
Cannabidiol (PgP inhibitor) AUC ↑2.5-fold If the moderate inhibitor is
Cmax ↑2.5-fold discontinued, consider a washout
Fluconazole Not studied. Increased exposure period of at least 2 to 3 days
Diltiazem expected. (average elimination time for most
Dronedarone Not studied. Increased exposure commonly used moderate inhibitors)
expected. before the Votubia dose is returned
Amprenavir, fosamprenavir Not studied. Increased exposure to the dose used prior to initiation of
expected. the co-administration. The
everolimus trough concentration
should be assessed at least 1 week
later (see sections 4.2 and 4.4).
Grapefruit juice or other Not studied. Increased exposure Combination should be avoided.
food affecting CYP3A4/PgP expected (the effect varies
widely).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) diltiazem (HOS-086288) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) dronedarone (HOS-086144) ketoconazole (HOS-084513) grapefruit juice (HOS-088787) cannabidiol (HOS-090609) imatinib (HOS-110212) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) fluconazole (HOS-087945) clarithromycin (HOS-084517) erythromycin (HOS-084514) amprenavir (HOS-086183) darunavir (HOS-086181) fosamprenavir (HOS-086182) ritonavir (HOS-084521) posaconazole (HOS-085622) verapamil (HOS-090602)
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Version 2025-11-20T17:40:00Z · SHA-256 252b066ec590fdab1f3eb7eccacdb5c7e91ec79421c970096d1b5261820faba4 · Passage ddc95e209a3f4d8e5376fa36e344d27d483981c2f805f567ef2fb4a51b8f3e0c · Zeichen 1012–4524 im Abschnitt
Wechselwirkungen · Docetaxel Kabi
DOCETAXEL KABI 20 mg/1 ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 11
HOS-214505 · Präparat HOS-155350
In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may
increase, as a result of reduced metabolism. If the concomitant use of a strong CYP3A4 inhibitor (e.g.,
ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin and voriconazole) cannot be avoided, a close clinical surveillance is warranted and a
dose-adjustment of docetaxel may be suitable during the treatment with the strong CYP3A4 inhibitor
(see section 4.4). In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with
the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
49%.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
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Version 2025-08-04T15:44:00Z · SHA-256 4ec115d98d201d84de2340a9fdabdd8a6db17b0a20954d72cafab8a7e3eaf6e6 · Passage f640897b581648a671549528599a0e77c0e915b1bc7804c45ad024fcf812c54f · Zeichen 778–1486 im Abschnitt
Wechselwirkungen · Docetaxel Kabi
DOCETAXEL KABI 80 mg/4 ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 57
HOS-214631 · Präparat HOS-155350
In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may
increase, as a result of reduced metabolism. If the concomitant use of a strong CYP3A4 inhibitor (e.g.,
ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin and voriconazole) cannot be avoided, a close clinical surveillance is warranted and a
dose-adjustment of docetaxel may be suitable during the treatment with the strong CYP3A4 inhibitor
(see section 4.4). In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with
the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
49%.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
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Version 2025-08-04T15:44:00Z · SHA-256 4ec115d98d201d84de2340a9fdabdd8a6db17b0a20954d72cafab8a7e3eaf6e6 · Passage f640897b581648a671549528599a0e77c0e915b1bc7804c45ad024fcf812c54f · Zeichen 778–1486 im Abschnitt
Wechselwirkungen · Docetaxel Kabi
DOCETAXEL KABI 120 mg/6 ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 103
HOS-214749 · Präparat HOS-155350
In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may
increase, as a result of reduced metabolism. If the concomitant use of a strong CYP3A4 inhibitor (e.g.,
ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin and voriconazole) cannot be avoided, a close clinical surveillance is warranted and a
dose-adjustment of docetaxel may be suitable during the treatment with the strong CYP3A4 inhibitor
(see section 4.4). In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with
the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
49%.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-04T15:44:00Z · SHA-256 4ec115d98d201d84de2340a9fdabdd8a6db17b0a20954d72cafab8a7e3eaf6e6 · Passage f640897b581648a671549528599a0e77c0e915b1bc7804c45ad024fcf812c54f · Zeichen 778–1486 im Abschnitt
Wechselwirkungen · Docetaxel Kabi
DOCETAXEL KABI 160 mg/8 ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 149
HOS-214867 · Präparat HOS-155350
In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may
increase, as a result of reduced metabolism. If the concomitant use of a strong CYP3A4 inhibitor (e.g.,
ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin and voriconazole) cannot be avoided, a close clinical surveillance is warranted and a
dose-adjustment of docetaxel may be suitable during the treatment with the strong CYP3A4 inhibitor
(see section 4.4). In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with
the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
49%.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-04T15:44:00Z · SHA-256 4ec115d98d201d84de2340a9fdabdd8a6db17b0a20954d72cafab8a7e3eaf6e6 · Passage f640897b581648a671549528599a0e77c0e915b1bc7804c45ad024fcf812c54f · Zeichen 777–1485 im Abschnitt
Wechselwirkungen · Docetaxel Kabi
DOCETAXEL KABI 180 mg/9 ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 195
HOS-214982 · Präparat HOS-155350
In case of combination with CYP3A4 inhibitors, the occurrence of docetaxel adverse reactions may
increase, as a result of reduced metabolism. If the concomitant use of a strong CYP3A4 inhibitor (e.g.,
ketoconazole, itraconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin and voriconazole) cannot be avoided, a close clinical surveillance is warranted and a
dose-adjustment of docetaxel may be suitable during the treatment with the strong CYP3A4 inhibitor
(see section 4.4). In a pharmacokinetic study with 7 patients, the co-administration of docetaxel with
the strong CYP3A4 inhibitor ketoconazole leads to a significant decrease in docetaxel clearance by
49%.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-04T15:44:00Z · SHA-256 4ec115d98d201d84de2340a9fdabdd8a6db17b0a20954d72cafab8a7e3eaf6e6 · Passage f640897b581648a671549528599a0e77c0e915b1bc7804c45ad024fcf812c54f · Zeichen 778–1486 im Abschnitt
Wechselwirkungen · DuoResp Spiromax
DuoResp Spiromax 160 micrograms / 4.5 micrograms inhalation powder · Abschnitt 4.5 · PDF-Seite 8–9
HOS-215187 · Präparat HOS-155404
Potent inhibitors of CYP3A4 (e.g. ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin,
telithromycin, nefazodone and HIV protease inhibitors) are likely to markedly increase plasma levels of
budesonide and concomitant use should be avoided. If this is not possible the time interval between
administration of the inhibitor and budesonide should be as long as possible (see section 4.4). In patients
8
using potent CYP3A4 inhibitors, a fixed-dose combination of budesonide and formoterol fumarate dihydrate
maintenance and reliever therapy is not recommended.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nefazodone (HOS-084519) protease (HOS-085623) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) clarithromycin (HOS-084517) posaconazole (HOS-085622)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-24T17:52:00Z · SHA-256 42079bf4b69044dc4d633d260c46172c183d9e017cb9bfa60f9313d810771afa · Passage b2dc0364179139012ce8866aa27053d58830613395a4bdeaa8c6d763b9ac50ab · Zeichen 30–663 im Abschnitt
Wechselwirkungen · DuoResp Spiromax
DuoResp Spiromax 320 micrograms/9 micrograms inhalation powder · Abschnitt 4.5 · PDF-Seite 24
HOS-215219 · Präparat HOS-155404
Potent inhibitors of CYP3A4 (e.g. ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin,
telithromycin, nefazodone and HIV protease inhibitors) are likely to markedly increase plasma levels of
budesonide and concomitant use should be avoided. If this is not possible the time interval between
administration of the inhibitor and budesonide should be as long as possible (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nefazodone (HOS-084519) protease (HOS-085623) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) clarithromycin (HOS-084517) posaconazole (HOS-085622)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-24T17:52:00Z · SHA-256 42079bf4b69044dc4d633d260c46172c183d9e017cb9bfa60f9313d810771afa · Passage 2b8d210ade346742434d5717744afeaebbf69eda453427ae7b31ef35636e0c11 · Zeichen 30–435 im Abschnitt
Wechselwirkungen · Bosulif
Bosulif 100 mg film-coated tablets Bosulif 400 mg film-coated tablets Bosulif 500 mg film-coated tablets Bosulif 50 mg hard capsules Bosulif 100 mg hard capsules · Abschnitt 4.5 · PDF-Seite 10
HOS-125439 · Präparat HOS-096073
CYP3A inhibitors
The concomitant use of bosutinib with strong CYP3A inhibitors (including, but not limited to
itraconazole, ketoconazole, posaconazole, voriconazole, clarithromycin, telithromycin, nefazodone,
mibefradil, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, boceprevir, telaprevir,
grapefruit products including grapefruit juice) or moderate CYP3A inhibitors (including, but not
limited to fluconazole, ciprofloxacin, erythromycin, diltiazem, verapamil, amprenavir, atazanavir,
darunavir/ritonavir, fosamprenavir, aprepitant, crizotinib, imatinib) should be avoided, as an increase
in bosutinib plasma concentration will occur.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) diltiazem (HOS-086288) nefazodone (HOS-084519) lopinavir (HOS-086269) atazanavir (HOS-086180) nelfinavir (HOS-084520) ciprofloxacin (HOS-085177) ketoconazole (HOS-084513) crizotinib (HOS-116818) aprepitant (HOS-112506) mibefradil (HOS-125440) grapefruit juice (HOS-088787) imatinib (HOS-110212) voriconazole (HOS-084524) telaprevir (HOS-090618) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) fluconazole (HOS-087945) boceprevir (HOS-090617) clarithromycin (HOS-084517) erythromycin (HOS-084514) amprenavir (HOS-086183) darunavir (HOS-086181) fosamprenavir (HOS-086182) ritonavir (HOS-084521) posaconazole (HOS-085622) bosutinib (HOS-109449) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-12T15:15:00Z · SHA-256 86c38605c3386630b4591643bb4507bc13ee17f96b594c991ef48865ec55c6c0 · Passage bf891fc27dae495286d0ddabf1a684337d5b862d791c1636c6fade4c46be3a59 · Zeichen 50–707 im Abschnitt
Wechselwirkungen · Kadcyla
Kadcyla 100 mg powder for concentrate for solution for infusion Kadcyla 160 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 10
HOS-125641 · Präparat HOS-096111
In vitro metabolism studies in human liver microsomes suggest that DM1, a component of
trastuzumab emtansine, is metabolised mainly by CYP3A4 and, to a lesser extent, by CYP3A5.
Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin,
atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole)
with trastuzumab emtansine should be avoided due to the potential for an increase in DM1 exposure
and toxicity. Consider an alternate medicinal product with no or minimal potential to inhibit CYP3A4.
If concomitant use of strong CYP3A4 inhibitors is unavoidable, consider delaying trastuzumab
emtansine treatment until the strong CYP3A4 inhibitors have cleared from the circulation
(approximately 3 elimination half-lives of the inhibitors) when possible. If a strong CYP3A4 inhibitor
is co-administered and trastuzumab emtansine treatment cannot be delayed, patients should be closely
monitored for adverse reactions.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-16T10:48:00Z · SHA-256 5f39c8c258f5d481831223647435155eac55229f855fa7a5be78809b9685324b · Passage 6a06004b0067232dabcda4b784ebf301c2bf1279553ff214f11cbd8589e94cd0 · Zeichen 52–1046 im Abschnitt
Wechselwirkungen · Inlyta
Inlyta 1 mg film-coated tablets Inlyta 3 mg film-coated tablets Inlyta 5 mg film-coated tablets Inlyta 7 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7
HOS-125776 · Präparat HOS-096155
CYP3A4/5 inhibitors
Ketoconazole, a strong inhibitor of CYP3A4/5, administered at a dose of 400 mg once daily for
7 days, increased the mean area under the curve (AUC) 2-fold and Cmax 1.5-fold of a single 5-mg oral
dose of axitinib in healthy volunteers. Co-administration of axitinib with strong CYP3A4/5 inhibitors
(e.g. ketoconazole, itraconazole, clarithromycin, erythromycin, atazanavir, indinavir, nefazodone,
nelfinavir, ritonavir, saquinavir, and telithromycin) may increase axitinib plasma concentrations.
Grapefruit may also increase axitinib plasma concentrations. Selection of concomitant medicinal
products with no or minimal CYP3A4/5 inhibition potential is recommended. If a strong
CYP3A4/5 inhibitor must be co-administered, a dose adjustment of axitinib is recommended (see
section 4.2).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) nefazodone (HOS-084519) atazanavir (HOS-086180) nelfinavir (HOS-084520) ketoconazole (HOS-084513) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) clarithromycin (HOS-084517) erythromycin (HOS-084514) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-01-22T16:24:00Z · SHA-256 cc612ad4d90bdaa4ab6d3ad8d8feba6a08fdb9fc507a44800c7d74bb2da0dd43 · Passage 546fd0bf52dfbf04371be597b31a0dddf2caf195bd44afdf6c6c9b6fe12ec791 · Zeichen 176–980 im Abschnitt
Wechselwirkungen · Zelboraf
Zelboraf 240 mg film-coated tablets. · Abschnitt 4.5 · PDF-Seite 9
HOS-215565 · Präparat HOS-155464
Co-administration of itraconazole, a strong CYP3A4/Pgp inhibitor, increased steady state vemurafenib
AUC by approximately 40%. Vemurafenib should be used with caution in combination with strong
inhibitors of CYP3A4, glucuronidation and/or transport proteins (e.g. ritonavir, saquinavir,
telithromycin, ketoconazole, itraconazole, voriconazole, posaconazole, nefazodone, atazanavir).
Patients co-treated with such agents should be carefully monitored for safety and dose modifications
applied if clinically indicated (see Table 1 in section 4.2).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nefazodone (HOS-084519) atazanavir (HOS-086180) ketoconazole (HOS-084513) voriconazole (HOS-084524) telithromycin (HOS-084523) itraconazole (HOS-084516) saquinavir (HOS-084522) ritonavir (HOS-084521) posaconazole (HOS-085622)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-06-19T10:15:00Z · SHA-256 2d456fa760308f0a3cd38ceefcce188400597f529dcb630f5163ed6664af53db · Passage ba548b07daa9ea4dadbcba78eda656c8a60a2fd5ffe3009ddd8cd3838af53e75 · Zeichen 5391–5936 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.