Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 96 Präparate · 6744 Quellenpassagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Fareston
Fareston 60 mg tablets · Abschnitt 4.5 · PDF-Seite 4
HOS-085591 · Präparat HOS-083163
An additive effect on QT interval prolongation between Fareston and the following drugs and other
medicinal products that may prolong the QTc interval cannot be excluded. This might lead to an
increased risk of ventricular arrhythmias, including Torsade de pointes. Therefore co-administration
of Fareston with any of the following medicinal products is contraindicated (see also section 4.3):
- antiarrhythmics class IA (e.g. quinidine, hydroquinidine, disopyramide)
- antiarrhythmics class III (e.g. amiodarone, sotalol, dofetilide, ibutilide)
- neuroleptics (e.g. phenothiazines, pimozide, sertindole, haloperidol, sultopride)
- certain antimicrobials agents (moxifloxacin, erythromycin IV, pentamidine, antimalarials
particularly halofantrine)
- certain antihistaminics (terfenadine, astemizole, mizolastine)
- others (cisapride, vincamine IV, bepridil, diphemanil).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): pentamidine (HOS-085605) halofantrine (HOS-085606) terfenadine (HOS-085607) astemizole (HOS-085608) mizolastine (HOS-085609) cisapride (HOS-085610) vincamine (HOS-085611) bepridil (HOS-085612) diphemanil (HOS-085613) erythromycin (HOS-084514) lead (HOS-085592) quinidine (HOS-085593) hydroquinidine (HOS-085594) disopyramide (HOS-085595) amiodarone (HOS-085596) sotalol (HOS-085597) dofetilide (HOS-085598) ibutilide (HOS-085599) pimozide (HOS-085600) sertindole (HOS-085601) haloperidol (HOS-085602) sultopride (HOS-085603) moxifloxacin (HOS-085604)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-30T12:24:00Z · SHA-256 3b25a11bbd424fca19782652cfc8662dd4db79f69f35943c40313fed13e66e0e · Passage 9429395d1b572fb000ebac0968a84f8f195781287110169960c945b4772df6c6 · Zeichen 0–900 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.3 · PDF-Seite 4
HOS-086138 · Präparat HOS-083284
Concomitant medicinal product levels increased or decreased
1-Adrenoreceptor Alfuzosin Increased plasma concentrations of alfuzosin
Antagonist which may lead to severe hypotension (see
section 4.5).
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecanide,
encainide, flecanide, propafenone, quinidine. Thereby, increasing the
propafenone, quinidine risk of arrhythmias or other serious adverse
reactions from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): encainide (HOS-086145) propafenone (HOS-084530) quinidine (HOS-085593) fusidic acid (HOS-086146) colchicine (HOS-086147) astemizole (HOS-085608) terfenadine (HOS-085607) lurasidone (HOS-086148) clozapine (HOS-086149) pimozide (HOS-085600) quetiapine (HOS-086150) bepridil (HOS-085612) dronedarone (HOS-086144) alfuzosin (HOS-086139) lead (HOS-085592) propoxyphene (HOS-086140) ranolazine (HOS-086141) neratinib (HOS-086142) venetoclax (HOS-086143) amiodarone (HOS-085596)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f9fe97979894eedcce9660008265f9fc818cdb3984974bb2555b6c5e5869e4e5 · Zeichen 902–5292 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 35–36
HOS-086388 · Präparat HOS-083284
35
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecainide,
encainide, flecainide, propafenone, quinidine. Thereby, increasing
propafenone, quinidine the risk of arrhythmias or other serious adverse
effects from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Ergot Derivatives Dihydroergotamine, Increased plasma concentrations of ergot
ergonovine, derivatives leading to acute ergot toxicity,
ergotamine, including vasospasm and ischaemia.
methylergonovine
GI motility agent Cisapride Increased plasma concentrations of cisapride.
Thereby, increasing the risk of serious
arrhythmias from this agent.
Lipid-modifying agents
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lead (HOS-085592) dihydroergotamine (HOS-086152) ergonovine (HOS-086153) ergotamine (HOS-086154) methylergonovine (HOS-086155) cisapride (HOS-085610) quinidine (HOS-085593) fusidic acid (HOS-086146) astemizole (HOS-085608) terfenadine (HOS-085607) colchicine (HOS-086147) lurasidone (HOS-086148) clozapine (HOS-086149) pimozide (HOS-085600) quetiapine (HOS-086150) propoxyphene (HOS-086140) ranolazine (HOS-086141) neratinib (HOS-086142) venetoclax (HOS-086143) amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) encainide (HOS-086145) flecainide (HOS-086203) propafenone (HOS-084530)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f76b82bf2af9e33f5778d35af3ff4a8ea2ea8d392666af7950204db67ec4ac88 · Zeichen 1234–5743 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 18
HOS-086278 · Präparat HOS-083284
Antipsychotics/Neuroleptics
Clozapine, pimozide Ritonavir co-administration is likely to result in increased plasma concentrations of
clozapine or pimozide and is therefore contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): clozapine (HOS-086149) pimozide (HOS-085600)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f9b673d4bcfd59f47bb6c54c40be4618c80a44972f74bc511b794d09c8b64bb1 · Zeichen 37523–37792 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 51
HOS-086458 · Präparat HOS-083284
Antipsychotics/Neuroleptics
Clozapine, pimozide Ritonavir co-administration is likely to result in increased plasma concentrations of
clozapine or pimozide and is therefore contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): clozapine (HOS-086149) pimozide (HOS-085600)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f9b673d4bcfd59f47bb6c54c40be4618c80a44972f74bc511b794d09c8b64bb1 · Zeichen 39314–39583 im Abschnitt
Wechselwirkungen · Exelon
Exelon 1.5 mg hard capsules Exelon 3.0 mg hard capsules Exelon 4.5 mg hard capsules Exelon 6.0 mg hard capsules · Abschnitt 4.5 · PDF-Seite 6
HOS-087795 · Präparat HOS-083555
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine
should be observed with caution and clinical monitoring (ECG) may also be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): diphemanil (HOS-085613) erythromycin (HOS-084514) methadone (HOS-086198) pentamidine (HOS-085605) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602) droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) chlorpromazine (HOS-087796) sulpiride (HOS-087797) sultopride (HOS-085603)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-02-24T11:34:00Z · SHA-256 de7d3796de42471f695291c0766fcf1a2fe650dc43b810dbff52cb58532f22d3 · Passage 154d6b61b7e191c68cf01d41c614dc042e430118597578b05335dd0fcb9503bd · Zeichen 1110–1692 im Abschnitt
Wechselwirkungen · Exelon
Exelon 2 mg/ml oral solution · Abschnitt 4.5 · PDF-Seite 22
HOS-087828 · Präparat HOS-083555
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine
should be observed with caution and clinical monitoring (ECG) may also be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sulpiride (HOS-087797) sultopride (HOS-085603) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602) droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) diphemanil (HOS-085613) erythromycin (HOS-084514) methadone (HOS-086198) pentamidine (HOS-085605) chlorpromazine (HOS-087796)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-02-24T11:34:00Z · SHA-256 de7d3796de42471f695291c0766fcf1a2fe650dc43b810dbff52cb58532f22d3 · Passage 154d6b61b7e191c68cf01d41c614dc042e430118597578b05335dd0fcb9503bd · Zeichen 1111–1693 im Abschnitt
Wechselwirkungen · Exelon
Exelon 4.6 mg/24 h transdermal patch Exelon 9.5 mg/24 h transdermal patch Exelon 13.3 mg/24 h transdermal patch · Abschnitt 4.5 · PDF-Seite 39
HOS-087855 · Präparat HOS-083555
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): chlorpromazine (HOS-087796) sulpiride (HOS-087797) sultopride (HOS-085603) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602) droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) diphemanil (HOS-085613) erythromycin (HOS-084514) methadone (HOS-086198) pentamidine (HOS-085605)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-02-24T11:34:00Z · SHA-256 de7d3796de42471f695291c0766fcf1a2fe650dc43b810dbff52cb58532f22d3 · Passage ff4a6089869c9cad9b1692c6af2335103d7143b0e75d26f251dc054a8dc03d56 · Zeichen 1197–1695 im Abschnitt
Wechselwirkungen · Prometax
Prometax 1.5 mg hard capsules Prometax 3.0 mg hard capsules Prometax 4.5 mg hard capsules Prometax 6.0 mg hard capsules · Abschnitt 4.5 · PDF-Seite 6
HOS-090120 · Präparat HOS-084005
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine
should be observed with caution and clinical monitoring (ECG) may also be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): chlorpromazine (HOS-087796) sulpiride (HOS-087797) sultopride (HOS-085603) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602) droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) diphemanil (HOS-085613) erythromycin (HOS-084514) methadone (HOS-086198) pentamidine (HOS-085605)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-04-15T14:03:00Z · SHA-256 84780fda687229b6eb4fb8cc5e55f033116dac099756163d6052747dd50b9054 · Passage 154d6b61b7e191c68cf01d41c614dc042e430118597578b05335dd0fcb9503bd · Zeichen 1110–1692 im Abschnitt
Wechselwirkungen · Prometax
Prometax 2 mg/ml oral solution · Abschnitt 4.5 · PDF-Seite 20
HOS-090145 · Präparat HOS-084005
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine
should be observed with caution and clinical monitoring (ECG) may also be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sulpiride (HOS-087797) sultopride (HOS-085603) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602) droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) diphemanil (HOS-085613) erythromycin (HOS-084514) methadone (HOS-086198) pentamidine (HOS-085605) chlorpromazine (HOS-087796)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-04-15T14:03:00Z · SHA-256 84780fda687229b6eb4fb8cc5e55f033116dac099756163d6052747dd50b9054 · Passage 154d6b61b7e191c68cf01d41c614dc042e430118597578b05335dd0fcb9503bd · Zeichen 1111–1693 im Abschnitt
Wechselwirkungen · Prometax
Prometax 4.6 mg/24 h transdermal patch Prometax 9.5 mg/24 h transdermal patch Prometax 13.3 mg/24 h transdermal patch · Abschnitt 4.5 · PDF-Seite 35
HOS-090170 · Präparat HOS-084005
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of
rivastigmine with QT prolongation- or torsades de pointes-inducing medicinal products such as
antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride,
sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram,
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): droperidol (HOS-087801) cisapride (HOS-085610) citalopram (HOS-087802) chlorpromazine (HOS-087796) sulpiride (HOS-087797) sultopride (HOS-085603) amisulpride (HOS-087798) tiapride (HOS-087799) veralipride (HOS-087800) pimozide (HOS-085600) haloperidol (HOS-085602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-04-15T14:03:00Z · SHA-256 84780fda687229b6eb4fb8cc5e55f033116dac099756163d6052747dd50b9054 · Passage 40e0d9446db8c9b0543775c3feb5f361ddfae62f03137c84a0fd80d22e575530 · Zeichen 1199–1602 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.