Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 871 Präparate · 48256 Quellenpassagen · 124 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Rilutek
RILUTEK 50 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4
HOS-085901 · Präparat HOS-083218
In vitro studies using human liver microsomal preparations suggest that CYP 1A2 is the principal
isozyme involved in the initial oxidative metabolism of riluzole. Inhibitors of CYP 1A2 (e.g. caffeine,
diclofenac, diazepam, nicergoline, clomipramine, imipramine, fluvoxamine, phenacetin, theophylline,
amitriptyline and quinolones) could potentially decrease the rate of riluzole elimination, while
inducers of CYP 1A2 (e.g. cigarette smoke, charcoal-broiled food, rifampicin and omeprazole) could
increase the rate of riluzole elimination.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): caffeine (HOS-085902) diclofenac (HOS-085903) diazepam (HOS-085904) nicergoline (HOS-085905) clomipramine (HOS-085906) imipramine (HOS-085907) fluvoxamine (HOS-085908) phenacetin (HOS-085909) theophylline (HOS-085910) amitriptyline (HOS-085911) omeprazole (HOS-085912)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-08-21T15:14:00Z · SHA-256 28308676bb4846e6870c25018d4060663e4807dea55f5bd8c86ddbf568ed66d2 · Passage 46579b19e7adf1bcce4445191bd46b5d02b5de4a0e063e9ceff4cb863bea1be8 · Zeichen 109–648 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 24
HOS-086344 · Präparat HOS-083284
Proton pump inhibitors and H2-receptor antagonists
Proton pump inhibitors and H2-receptor antagonists (e.g. omeprazole or ranitidine) may reduce
concentrations for co-administered protease inhibitors. For specific information regarding the impact
of co-administration of acid reducing agents, refer to the SmPC of the co-administered protease
inhibitor. Based on interaction studies with the ritonavir boosted protease inhibitors
(lopinavir/ritonavir, atazanavir), concurrent administration of omeprazole or ranitidine does not
significantly modify ritonavir efficacy as a pharmacokinetic enhancer despite a slight change of
exposure (about 6 - 18%).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) ranitidine (HOS-085660) protease (HOS-085623) lopinavir (HOS-086269) atazanavir (HOS-086180)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 3c27321459baa7b0705afde806e8b539a0a25a4b47e2383e187fb6fd8f60bfb2 · Zeichen 60628–61278 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 56
HOS-086497 · Präparat HOS-083284
Proton pump inhibitors and H2-receptor antagonists
Proton pump inhibitors and H2-receptor antagonists (e.g. omeprazole or ranitidine) may reduce
concentrations for co-administered protease inhibitors. For specific information regarding the impact
of co-administration of acid reducing agents, refer to the SmPC of the co-administered protease
inhibitor. Based on interaction studies with the ritonavir boosted protease inhibitors
(lopinavir/ritonavir, atazanavir), concurrent administration of omeprazole or ranitidine does not
significantly modify ritonavir efficacy as a pharmacokinetic enhancer despite a slight change of
exposure (about 6 - 18%).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) ranitidine (HOS-085660) protease (HOS-085623) lopinavir (HOS-086269) atazanavir (HOS-086180)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 4de66caff969925d9ad024610386f020326d8902794177858246b69263b12d3c · Zeichen 62968–63646 im Abschnitt
Wechselwirkungen · Plavix
Plavix 75 mg film-coated tablets Plavix 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-087943 · Präparat HOS-083591
Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole
and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine,
carbamazepine, and efavirenz.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): esomeprazole (HOS-087944) fluvoxamine (HOS-085908) fluoxetine (HOS-085946) moclobemide (HOS-087879) voriconazole (HOS-084524) fluconazole (HOS-087945) ticlopidine (HOS-087946) carbamazepine (HOS-085618) efavirenz (HOS-087947) omeprazole (HOS-085912)
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Version 2025-07-14T12:15:00Z · SHA-256 1e6a9d1e2861882ccf51f6506686a24b3c88e112fad66a7a9333c6e88547592c · Passage 6adad8692c6fecb943bf126bdc5047021725d2d6aca1b2738e493857127bf04c · Zeichen 4217–4441 im Abschnitt
Wechselwirkungen · Plavix
Plavix 75 mg film-coated tablets Plavix 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-087948 · Präparat HOS-083591
Proton Pump Inhibitors (PPI):
Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours
between the administrations of the two drugs decreased the exposure of the active metabolite by 45%
(loading dose) and 40% (maintenance dose). The decrease was associated with a 39% (loading dose)
and 21% (maintenance dose) reduction of inhibition of platelet aggregation. Esomeprazole is expected
to give a similar interaction with clopidogrel.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) esomeprazole (HOS-087944)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-14T12:15:00Z · SHA-256 1e6a9d1e2861882ccf51f6506686a24b3c88e112fad66a7a9333c6e88547592c · Passage 9803407e3e77358db95500730a4014dbba252f7a14b71545d5c25050a5af0d47 · Zeichen 4443–4915 im Abschnitt
Wechselwirkungen · Plavix
Plavix 75 mg film-coated tablets Plavix 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-087949 · Präparat HOS-083591
Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD)
interaction in terms of major cardiovascular events have been reported from both observational and
clinical studies. As a precaution, concomitant use of omeprazole or esomeprazole should be
discouraged (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) esomeprazole (HOS-087944)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-14T12:15:00Z · SHA-256 1e6a9d1e2861882ccf51f6506686a24b3c88e112fad66a7a9333c6e88547592c · Passage f2908ec8a74d907a4a77706921789e33b1e9e3299d040ad1fa9775bca4d02e4e · Zeichen 4917–5234 im Abschnitt
Wechselwirkungen · Iscover
Iscover 75 mg film-coated tablets Iscover 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-087998 · Präparat HOS-083599
Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole
and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine,
carbamazepine, and efavirenz.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) esomeprazole (HOS-087944) fluvoxamine (HOS-085908) fluoxetine (HOS-085946) moclobemide (HOS-087879) voriconazole (HOS-084524) fluconazole (HOS-087945) ticlopidine (HOS-087946) carbamazepine (HOS-085618) efavirenz (HOS-087947)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-26T11:41:00Z · SHA-256 3fe5799ec5f9f1d2b848168c6cfaf56d702c6bce3141e7d7aa95ef81abbc8acc · Passage 6adad8692c6fecb943bf126bdc5047021725d2d6aca1b2738e493857127bf04c · Zeichen 4216–4440 im Abschnitt
Wechselwirkungen · Iscover
Iscover 75 mg film-coated tablets Iscover 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-087999 · Präparat HOS-083599
Proton Pump Inhibitors (PPI):
Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours
between the administrations of the two drugs decreased the exposure of the active metabolite by 45%
(loading dose) and 40% (maintenance dose). The decrease was associated with a 39% (loading dose)
and 21% (maintenance dose) reduction of inhibition of platelet aggregation. Esomeprazole is expected
to give a similar interaction with clopidogrel.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): esomeprazole (HOS-087944) omeprazole (HOS-085912)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-26T11:41:00Z · SHA-256 3fe5799ec5f9f1d2b848168c6cfaf56d702c6bce3141e7d7aa95ef81abbc8acc · Passage 9803407e3e77358db95500730a4014dbba252f7a14b71545d5c25050a5af0d47 · Zeichen 4442–4914 im Abschnitt
Wechselwirkungen · Iscover
Iscover 75 mg film-coated tablets Iscover 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-088000 · Präparat HOS-083599
Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD)
interaction in terms of major cardiovascular events have been reported from both observational and
clinical studies. As a precaution, concomitant use of omeprazole or esomeprazole should be
discouraged (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) esomeprazole (HOS-087944)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-26T11:41:00Z · SHA-256 3fe5799ec5f9f1d2b848168c6cfaf56d702c6bce3141e7d7aa95ef81abbc8acc · Passage f2908ec8a74d907a4a77706921789e33b1e9e3299d040ad1fa9775bca4d02e4e · Zeichen 4916–5233 im Abschnitt
Wechselwirkungen · Kaletra
Kaletra (80 mg + 20 mg) / ml oral solution · Abschnitt 4.5 · PDF-Seite 12
HOS-108852 · Präparat HOS-093083
(inhibition of CYP3A enzymes)
HIV CCR5 – antagonist
Maraviroc Maraviroc: The dose of maraviroc should be
AUC: ↑ 295% decreased to 150 mg twice daily
Cmax: ↑ 97% during co-administration with
Due to CYP3A inhibition by Kaletra 400/100 mg twice daily.
lopinavir/ritonavir.
Integrase inhibitor
Raltegravir Raltegravir: No dose adjustment necessary
AUC: ↔
Cmax: ↔
C12: ↓ 30%
Lopinavir: ↔
Co-administration with other HIV protease inhibitors (PIs)
According to current treatment guidelines, dual therapy with protease inhibitors is generally not
recommended.
Fosamprenavir/ ritonavir Fosamprenavir: Co-administration of increased
(700/100 mg BID) Amprenavir concentrations are doses of fosamprenavir (1400 mg
significantly reduced. BID) with Kaletra oral solution
(Lopinavir/ritonavir (533/133 mg BID) to protease
400/100 mg BID) inhibitor-experienced patients
resulted in a higher incidence of
or gastrointestinal adverse events and
elevations in triglycerides with the
Fosamprenavir (1400 mg combination regimen without
BID) increases in virological efficacy,
when compared with standard
(Lopinavir/ritonavir doses of fosamprenavir/ritonavir.
533/133 mg BID) Concomitant administration of
these medicinal products is not
recommended.
Tipranavir/ritonavir Lopinavir: Concomitant administration of
(500/100 mg BID) AUC: ↓ 55% these medicinal products is not
Cmin: ↓ 70% recommended.
Cmax: ↓ 47%
Acid reducing agents
Omeprazole (40 mg QD) Omeprazole: ↔ No dose adjustment necessary
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): amprenavir (HOS-086183) tipranavir (HOS-086184) omeprazole (HOS-085912) maraviroc (HOS-086186) raltegravir (HOS-086187) protease (HOS-085623) fosamprenavir (HOS-086182)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage 0b87fdd109f79a80601e3c574f5e18fed07b1789a2ca7f01d2eafaba29d23dc3 · Zeichen 4995–7833 im Abschnitt
Wechselwirkungen · Kaletra
Kaletra 200 mg/50 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 48–49
HOS-109005 · Präparat HOS-093083
48
(Lopinavir/ritonavir resulted in a higher incidence of
400/100 mg BID) gastrointestinal adverse events and
elevations in triglycerides with the
or combination regimen without
increases in virological efficacy,
Fosamprenavir when compared with standard doses
(1400 mg BID) of fosamprenavir/ritonavir.
Concomitant administration of these
(Lopinavir/ritonavir medicinal products is not
533/133 mg BID) recommended.
Kaletra must not be administered
once daily in combination with
amprenavir.
Tipranavir/ritonavir Lopinavir: Concomitant administration of these
(500/100 mg BID) AUC: ↓ 55% medicinal products is not
Cmin: ↓ 70% recommended.
Cmax: ↓ 47%
Acid reducing agents
Omeprazole (40 mg Omeprazole: ↔ No dose adjustment necessary
QD)
Lopinavir: ↔
Ranitidine (150 mg Ranitidine: ↔ No dose adjustment necessary
single dose)
Alpha1 adrenoreceptor antagonist
Alfuzosin Alfuzosin: Concomitant administration of
Due to CYP3A inhibition by Kaletra and alfuzosin is contra-
lopinavir/ritonavir, concentrations indicated (see section 4.3) as
of alfuzosin are expected to alfuzosin-related toxicity, including
increase. hypotension, may be increased.
Analgesics
Fentanyl Fentanyl: Careful monitoring of adverse effects
Increased risk of side-effects (notably respiratory depression but
(respiratory depression, sedation) also sedation) is recommended when
due to higher plasma fentanyl is concomitantly
concentrations because of administered with Kaletra.
CYP3A4 inhibition by
lopinavir/ritonavir.
Antianginal
Ranolazine Due to CYP3A inhibition by The concomitant administration of
lopinavir/ritonavir, concentrations Kaletra and ranolazine is
of ranolazine are expected to contraindicated (see section 4.3).
increase.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): fentanyl (HOS-086196) ranolazine (HOS-086141) fosamprenavir (HOS-086182) amprenavir (HOS-086183) tipranavir (HOS-086184) omeprazole (HOS-085912) ranitidine (HOS-085660) alfuzosin (HOS-086139)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage 36be30eaedda7aebc321ed321c96a33a8b5f0e47dfdc414ad4d6358ff3954c0c · Zeichen 6614–9803 im Abschnitt
Wechselwirkungen · Kaletra
Kaletra 100 mg/25 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 83–84
HOS-109078 · Präparat HOS-093083
83
Maraviroc Maraviroc: The dose of maraviroc should be
AUC: ↑ 295% decreased to 150 mg twice daily
Cmax: ↑ 97% during co-administration with
Due to CYP3A inhibition by Kaletra 400/100 mg twice daily.
lopinavir/ritonavir.
Integrase inhibitor
Raltegravir Raltegravir: No dose adjustment necessary
AUC: ↔
Cmax: ↔
C12: ↓ 30%
Lopinavir: ↔
Co-administration with other HIV protease inhibitors (PIs)
According to current treatment guidelines, dual therapy with protease inhibitors is generally not
recommended.
Fosamprenavir/ Fosamprenavir: Co-administration of increased
ritonavir (700/100 mg Amprenavir concentrations are doses of fosamprenavir (1400 mg
BID) significantly reduced. BID) with Kaletra oral solution
(533/133 mg BID) to protease
(Lopinavir/ritonavir inhibitor-experienced patients
400/100 mg BID) resulted in a higher incidence of
gastrointestinal adverse events and
or elevations in triglycerides with the
combination regimen without
Fosamprenavir increases in virological efficacy,
(1400 mg BID) when compared with standard doses
of fosamprenavir/ritonavir.
(Lopinavir/ritonavir Concomitant administration of these
533/133 mg BID) medicinal products is not
recommended.
Kaletra must not be administered
once daily in combination with
amprenavir.
Tipranavir/ritonavir Lopinavir: Concomitant administration of these
(500/100 mg BID) AUC: ↓ 55% medicinal products is not
Cmin: ↓ 70% recommended.
Cmax: ↓ 47%
Acid reducing agents
Omeprazole (40 mg Omeprazole: ↔ No dose adjustment necessary
QD)
Lopinavir: ↔
Ranitidine (150 mg Ranitidine: ↔ No dose adjustment necessary
single dose)
Alpha1 adrenoreceptor antagonist
Alfuzosin Alfuzosin: Concomitant administration of
Due to CYP3A inhibition by Kaletra and alfuzosin is contra-
lopinavir/ritonavir, concentrations indicated (see section 4.3) as
of alfuzosin are expected to alfuzosin-related toxicity, including
increase. hypotension, may be increased.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) maraviroc (HOS-086186) raltegravir (HOS-086187) protease (HOS-085623) fosamprenavir (HOS-086182) amprenavir (HOS-086183) tipranavir (HOS-086184) omeprazole (HOS-085912) ranitidine (HOS-085660)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage 262bfc7747e8af6a0bc31322576cc9f33731bdf23847197000d08285e923bde2 · Zeichen 5337–8975 im Abschnitt
Wechselwirkungen · Dynastat
Dynastat 40 mg powder for solution for injection · Abschnitt 4.5 · PDF-Seite 7
HOS-109365 · Präparat HOS-093187
Plasma exposure of omeprazole (CYP 2C19 substrate) 40 mg once daily was increased by 46%
following administration of valdecoxib 40 mg twice daily for 7 days, while the plasma exposure to
valdecoxib was unaffected. These results indicate that although valdecoxib is not metabolised by
CYP2C19, it may be an inhibitor of this isoenzyme. Therefore, caution should be observed when
administering Dynastat with medicinal products known to be substrates of CYP2C19 (e.g. phenytoin,
diazepam, or imipramine).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) valdecoxib (HOS-109357) phenytoin (HOS-084531) diazepam (HOS-085904) imipramine (HOS-085907)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-03-05T17:26:00Z · SHA-256 a94a02bdad229376a395299eccbc2ab09dd742598fb29796b8e5ada490a65e06 · Passage 1174ed6865ef4da5a1bc4cf18b53d520c40718ae93707fd5f081a1005f418d36 · Zeichen 4177–4678 im Abschnitt
Wechselwirkungen · Dynastat
Dynastat 40 mg powder and solvent for solution for injection · Abschnitt 4.5 · PDF-Seite 23
HOS-109409 · Präparat HOS-093187
Plasma exposure of omeprazole (CYP 2C19 substrate) 40 mg once daily was increased by 46%
following administration of valdecoxib 40 mg twice daily for 7 days, while the plasma exposure to
valdecoxib was unaffected. These results indicate that although valdecoxib is not metabolised by
CYP2C19, it may be an inhibitor of this isoenzyme. Therefore, caution should be observed when
administering Dynastat with medicinal products known to be substrates of CYP2C19 (e.g. phenytoin,
diazepam, or imipramine).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): omeprazole (HOS-085912) valdecoxib (HOS-109357) phenytoin (HOS-084531) diazepam (HOS-085904) imipramine (HOS-085907)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-03-05T17:26:00Z · SHA-256 a94a02bdad229376a395299eccbc2ab09dd742598fb29796b8e5ada490a65e06 · Passage 1174ed6865ef4da5a1bc4cf18b53d520c40718ae93707fd5f081a1005f418d36 · Zeichen 4178–4679 im Abschnitt
Wechselwirkungen · Vfend
VFEND 50 mg film-coated tablets VFEND 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10
HOS-109442 · Präparat HOS-093201
Medicinal product Interaction Recommendations concerning
geometric mean changes (%) coadministration
Antacids
Cimetidine (400 mg BID) Voriconazole Cmax 18% No dose adjustment
[non-specific CYP450 inhibitor Voriconazole AUC 23%
and increases gastric pH]
Omeprazole (40 mg QD)* Omeprazole Cmax 116% No dose adjustment of
[CYP2C19 inhibitor; Omeprazole AUC 280% voriconazole is recommended.
CYP2C19 and CYP3A4 Voriconazole Cmax 15%
substrate] Voriconazole AUC 41% When initiating voriconazole in
patients already receiving
Other proton pump inhibitors omeprazole doses of 40 mg or
that are CYP2C19 substrates above, it is recommended that
may also be inhibited by the omeprazole dose be halved.
voriconazole and may result in
increased plasma concentrations
of these medicinal products.
Ranitidine (150 mg BID) Voriconazole Cmax and AUC ↔ No dose adjustment
[increases gastric pH]
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835) omeprazole (HOS-085912) ranitidine (HOS-085660)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage a964e1dd69cbc5960da5e707c3bb5a0af698c9648ed7477b2b8dc2f453d44a4f · Zeichen 2057–3491 im Abschnitt
Wechselwirkungen · Vfend
VFEND 200 mg powder for solution for infusion · Abschnitt 4.5 · PDF-Seite 42
HOS-109534 · Präparat HOS-093201
Medicinal product Interaction Recommendations concerning
geometric mean changes (%) coadministration
Antacids
Cimetidine (400 mg BID) Voriconazole Cmax 18% No dose adjustment
[non-specific CYP450 inhibitor Voriconazole AUC 23%
and increases gastric pH]
Omeprazole (40 mg QD)* Omeprazole Cmax 116% No dose adjustment of
[CYP2C19 inhibitor; Omeprazole AUC 280% voriconazole is recommended.
CYP2C19 and CYP3A4 Voriconazole Cmax 15%
substrate] Voriconazole AUC 41% When initiating voriconazole in
patients already receiving
Other proton pump inhibitors omeprazole doses of 40 mg or
that are CYP2C19 substrates above, it is recommended that
may also be inhibited by the omeprazole dose be halved.
voriconazole and may result in
increased plasma concentrations
of these medicinal products.
Ranitidine (150 mg BID) Voriconazole Cmax and AUC ↔ No dose adjustment
[increases gastric pH]
Antiarrhythmics
Digoxin (0.25 mg QD) Digoxin Cmax ↔ No dose adjustment
[P-gp substrate] Digoxin AUC ↔
Quinidine Although not studied, increased Contraindicated (see section
[CYP3A4 substrate] plasma concentrations of quinidine 4.3)
can lead to QTc prolongation and
rare occurrences of torsades de
pointes.
Antibacterials
Flucloxacillin Significantly decreased plasma If concomitant administration of
[CYP450 inducer] voriconazole concentrations have voriconazole with flucloxacillin
been reported. cannot be avoided, monitor for
potential loss of voriconazole
effectiveness (e.g., by therapeutic
drug monitoring); increasing the
dose of voriconazole may be
needed.
Macrolide antibiotics No dose adjustment
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835) omeprazole (HOS-085912) ranitidine (HOS-085660) digoxin (HOS-086172) quinidine (HOS-085593) lead (HOS-085592)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 534b27e000563107a8bd6c73d67131e3dbf51bbeeb2ec364adce0f84e9ccd348 · Zeichen 2117–4967 im Abschnitt
Wechselwirkungen · Vfend
VFEND 40 mg/ml powder for oral suspension · Abschnitt 4.5 · PDF-Seite 74
HOS-109598 · Präparat HOS-093201
Medicinal product Interaction Recommendations concerning
geometric mean changes (%) coadministration
Antacids
Cimetidine (400 mg BID) Voriconazole Cmax 18% No dose adjustment
[non-specific CYP450 inhibitor Voriconazole AUC 23%
and increases gastric pH]
Omeprazole (40 mg QD)* Omeprazole Cmax 116% No dose adjustment of
[CYP2C19 inhibitor; Omeprazole AUC 280% voriconazole is recommended.
CYP2C19 and CYP3A4 Voriconazole Cmax 15%
substrate] Voriconazole AUC 41% When initiating voriconazole in
patients already receiving
Other proton pump inhibitors omeprazole doses of 40 mg or
that are CYP2C19 substrates above, it is recommended that
may also be inhibited by the omeprazole dose be halved.
voriconazole and may result in
increased plasma concentrations
of these medicinal products.
Ranitidine (150 mg BID) Voriconazole Cmax and AUC ↔ No dose adjustment
[increases gastric pH]
Antiarrhythmics
Digoxin (0.25 mg QD) Digoxin Cmax ↔ No dose adjustment
[P-gp substrate] Digoxin AUC ↔
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835) omeprazole (HOS-085912) ranitidine (HOS-085660) digoxin (HOS-086172)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage bebd80b17ebeb6e13bb01acb51cf5fdac5c0fd4d76d9ee1c6a71e499a8005c19 · Zeichen 2057–3647 im Abschnitt
Wechselwirkungen · Xagrid
Xagrid 0.5 mg hard capsules. · Abschnitt 4.5 · PDF-Seite 5
HOS-111701 · Präparat HOS-093587
Effects of other active substances on anagrelide
In vivo interaction studies in humans have demonstrated that digoxin and warfarin do not affect
the pharmacokinetic properties of anagrelide.
CYP1A2 inhibitors
Anagrelide is primarily metabolised by CYP1A2. It is known that CYP1A2 is inhibited by
several medicinal products, including fluvoxamine and enoxacin, and such medicinal products
could theoretically adversely influence the clearance of anagrelide.
CYP1A2 inducers
CYP1A2 inducers (such as omeprazole) could decrease the exposure of anagrelide (see
section 5.2). The consequences on the safety and efficacy profile of anagrelide are not established.
Therefore, clinical and biological monitoring is recommended in patients taking concomitant
CYP1A2 inducers. If needed, anagrelide dose adjustment could be made.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): digoxin (HOS-086172) warfarin (HOS-085950) fluvoxamine (HOS-085908) enoxacin (HOS-111703) omeprazole (HOS-085912)
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Version 2023-02-20T12:00:00Z · SHA-256 87cdc695145c0255ddafd5a98b35d5237ee320bd26290f38f993752bd4763fab · Passage 603082c28f5d37d2448c54c7032cdcbcb40f39ceaa85e4abc664fafbae886638 · Zeichen 161–1024 im Abschnitt
Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 16–17
HOS-112089 · Präparat HOS-093615
16
Medicinal products by Interaction Recommendations concerning co-
therapeutic area administration
Proton pump inhibitors
Omeprazole 40 mg once daily Atazanavir (am): 2 hr after omeprazole Co-administration of REYATAZ
(atazanavir 400 mg once daily Atazanavir AUC: ↓61% (↓65% ↓55%) with ritonavir and proton pump
with ritonavir 100 mg once daily) Atazanavir Cmax: ↓66% (↓62% ↓49%) inhibitors is not recommended. If
Atazanavir Cmin: ↓65% (↓71% ↓59%) the combination is judged
Omeprazole 20 mg once daily Atazanavir (am): 1 hr after omeprazole unavoidable, close clinical
(atazanavir 400 mg once daily Atazanavir AUC: ↓30% (↓43% ↓14%)* monitoring is recommended in
with ritonavir 100 mg once daily) Atazanavir Cmax: ↓31% (↓42% ↓17%)* combination with an increase in the
Atazanavir Cmin: ↓31% (↓46% ↓12%)* dose of REYATAZ to 400 mg with
100 mg of ritonavir; doses of proton
*When compared to atazanavir 300 mg pump inhibitors comparable to
once daily with ritonavir 100 mg once omeprazole 20 mg should not be
daily. exceeded (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) omeprazole (HOS-085912)
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Version 2026-06-29T13:00:00Z · SHA-256 ff5481974bd7c752b73fa0c147cf3e96fc892edc735359fa71817833db471beb · Passage b1851bb3613af61c2ae6ffc33e18682bf713eda925506ce47a825ab3a1bc11dd · Zeichen 35861–37451 im Abschnitt
Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 17
HOS-112090 · Präparat HOS-093615
The decrease in AUC, Cmax, and Cmin was
not mitigated when an increased dose of
REYATAZ/ritonavir (400/100 mg once
daily) was temporally separated from
omeprazole by 12 hours. Although not
studied, similar results are expected with
other proton pump inhibitors. This
decrease in atazanavir exposure might
negatively impact the efficacy of
atazanavir. The mechanism of interaction
is decreased solubility of atazanavir as
intra-gastric pH increases with proton
pump inhibitors.
Antacids
Antacids and medicinal Reduced plasma concentrations of REYATAZ should be administered
products containing buffers atazanavir may be the consequence of 2 hours before or 1 hour after
increased gastric pH if antacids, including antacids or buffered medicinal
buffered medicinal products, are products.
administered with REYATAZ.
ALPHA 1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Potential for increased alfuzosin Co-administration of alfuzosin with
concentrations which can result in REYATAZ is contraindicated
hypotension. The mechanism of (see section 4.3)
interaction is CYP3A4 inhibition by
REYATAZ and/or ritonavir.
ANTICOAGULANTS
Direct-acting oral anticoagulants (DOACs)
Apixaban Potential for increased apixaban and Co-administration of apixaban or
Rivaroxaban rivaroxaban concentrations which can rivaroxaban and REYATAZ with
result in a higher risk of bleeding. ritonavir is not recommended.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) omeprazole (HOS-085912) alfuzosin (HOS-086139) apixaban (HOS-112091) rivaroxaban (HOS-086236)
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Version 2026-06-29T13:00:00Z · SHA-256 ff5481974bd7c752b73fa0c147cf3e96fc892edc735359fa71817833db471beb · Passage c2e1c404625f053010d018b68c609db0fa46e4ca86fdb8aa482fd8bcd7905174 · Zeichen 37490–39803 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.