Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Gegenanzeigen · Reyataz
REYATAZ 50 mg oral powder · Abschnitt 4.3 · PDF-Seite 40
HOS-112152 · Präparat HOS-093615
Co-administration with medicinal products that are substrates of the CYP3A4 isoform of cytochrome
P450 and have narrow therapeutic windows (e.g., quetiapine, alfuzosin, astemizole, terfenadine,
cisapride, pimozide, quinidine, lurasidone, bepridil, triazolam, midazolam administered orally (for
caution on parenterally administered midazolam, see section 4.5), lomitapide and ergot alkaloids,
particularly, ergotamine, dihydroergotamine, ergonovine, methylergonovine) (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) alfuzosin (HOS-086139) methylergonovine (HOS-086155) cisapride (HOS-085610) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) ergot alkaloids (HOS-108807) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Version 2026-06-29T13:00:00Z · SHA-256 ff5481974bd7c752b73fa0c147cf3e96fc892edc735359fa71817833db471beb · Passage e442989da36600ebf7f8db27c93ddf7cb3e10a213eeefa38bb99d1990671ccee · Zeichen 495–980 im Abschnitt
Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-112050 · Präparat HOS-093615
Atazanavir is metabolised in the liver through CYP3A4. It inhibits CYP3A4. Therefore, REYATAZ is
contraindicated with medicinal products that are substrates of CYP3A4 and have a narrow therapeutic
index: quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine,
bepridil, triazolam, orally administered midazolam, lomitapide, and ergot alkaloids, particularly
ergotamine and dihydroergotamine (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) alfuzosin (HOS-086139) cisapride (HOS-085610) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) ergot alkaloids (HOS-108807) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 17
HOS-112090 · Präparat HOS-093615
The decrease in AUC, Cmax, and Cmin was
not mitigated when an increased dose of
REYATAZ/ritonavir (400/100 mg once
daily) was temporally separated from
omeprazole by 12 hours. Although not
studied, similar results are expected with
other proton pump inhibitors. This
decrease in atazanavir exposure might
negatively impact the efficacy of
atazanavir. The mechanism of interaction
is decreased solubility of atazanavir as
intra-gastric pH increases with proton
pump inhibitors.
Antacids
Antacids and medicinal Reduced plasma concentrations of REYATAZ should be administered
products containing buffers atazanavir may be the consequence of 2 hours before or 1 hour after
increased gastric pH if antacids, including antacids or buffered medicinal
buffered medicinal products, are products.
administered with REYATAZ.
ALPHA 1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Potential for increased alfuzosin Co-administration of alfuzosin with
concentrations which can result in REYATAZ is contraindicated
hypotension. The mechanism of (see section 4.3)
interaction is CYP3A4 inhibition by
REYATAZ and/or ritonavir.
ANTICOAGULANTS
Direct-acting oral anticoagulants (DOACs)
Apixaban Potential for increased apixaban and Co-administration of apixaban or
Rivaroxaban rivaroxaban concentrations which can rivaroxaban and REYATAZ with
result in a higher risk of bleeding. ritonavir is not recommended.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) rivaroxaban (HOS-086236) apixaban (HOS-112091) ritonavir (HOS-084521) omeprazole (HOS-085912)
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Wechselwirkungen · Reyataz
REYATAZ 50 mg oral powder · Abschnitt 4.5 · PDF-Seite 44
HOS-112157 · Präparat HOS-093615
Atazanavir is metabolised in the liver through CYP3A4. It inhibits CYP3A4. Therefore, REYATAZ
with ritonavir is contraindicated with medicinal products that are substrates of CYP3A4 and have a
narrow therapeutic index: quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride,
pimozide, quinidine, bepridil, triazolam, orally administered midazolam, lomitapide, and ergot
alkaloids, particularly ergotamine and dihydroergotamine (see section 4.3). Co-administration of
REYATAZ with grazoprevir-containing products, including elbasvir/grazoprevir fixed-dose
combination is contraindicated because of the increase in grazoprevir and elbasvir plasma
concentrations and potential for the increase in risk of ALT elevations associated with increased
grazoprevir concentrations (see section 4.3). Co-administration of REYATAZ with
glecaprevir/pibrentasvir fixed-dose combination is contraindicated because of the potential increase in
the risk of ALT elevations due to a significant increase in glecapreir and pibrentasvir plasma
concentrations (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) elbasvir (HOS-108814) alfuzosin (HOS-086139) cisapride (HOS-085610) pibrentasvir (HOS-086298) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) glecaprevir (HOS-086297) grazoprevir (HOS-108815) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) ritonavir (HOS-084521) terfenadine (HOS-085607) lurasidone (HOS-086148) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Wechselwirkungen · Reyataz
REYATAZ 50 mg oral powder · Abschnitt 4.5 · PDF-Seite 52
HOS-112183 · Präparat HOS-093615
The mechanism of interaction is decreased
solubility of atazanavir as intra-gastric pH
increases with H2-blockers.
Proton pump inhibitors
Omeprazole 40 mg once daily Atazanavir (am): 2 hr after omeprazole Co-administration of
(atazanavir 400 mg once daily Atazanavir AUC: ↓61% (↓65% ↓55%) REYATAZ with ritonavir and
with ritonavir 100 mg once Atazanavir Cmax: ↓66% (↓62% ↓49%) proton pump inhibitors is not
daily) Atazanavir Cmin: ↓65% (↓71% ↓59%) recommended. If the
Omeprazole 20 mg once daily Atazanavir (am): 1 hr after omeprazole combination is judged
(atazanavir 400 mg once daily Atazanavir AUC: ↓30% (↓43% ↓14%)* unavoidable, close clinical
with ritonavir 100 mg once Atazanavir Cmax: ↓31% (↓42% ↓17%)* monitoring is recommended in
daily) Atazanavir Cmin: ↓31% (↓46% ↓12%)* combination with an increase
in the dose of REYATAZ to
*When compared to atazanavir 300 mg 400 mg with 100 mg of
once daily with ritonavir 100 mg once ritonavir; doses of proton
daily. pump inhibitors comparable to
omeprazole 20 mg should not
The decrease in AUC, Cmax, and Cmin was be exceeded (see section 4.4).
not mitigated when an increased dose of
REYATAZ/ritonavir (400/100 mg once
daily) was temporally separated from
omeprazole by 12 hours. Although not
studied, similar results are expected with
other proton pump inhibitors. This decrease
in atazanavir exposure might negatively
impact the efficacy of atazanavir. The
mechanism of interaction is decreased
solubility of atazanavir as intra-gastric pH
increases with proton pump inhibitors.
Antacids
Antacids and medicinal
Reduced plasma concentrations of REYATAZ should be
products containing buffers
atazanavir may be the consequence of administered 2 hours before or
increased gastric pH if antacids, including 1 hour after antacids or
buffered medicinal products, are buffered medicinal products.
administered with REYATAZ.
ALPHA 1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Potential for increased alfuzosin Co-administration of alfuzosin
concentrations which can result in with REYATAZ is
hypotension. The mechanism of interaction contraindicated (see
is CYP3A4 inhibition by REYATAZ section 4.3)
and/or ritonavir.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) ritonavir (HOS-084521) omeprazole (HOS-085912)
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Gegenanzeigen · Aptivus
Aptivus 250 mg soft capsules · Abschnitt 4.3 · PDF-Seite 4
HOS-114797 · Präparat HOS-094169
Co-administration of Aptivus with low dose ritonavir, with active substances that are highly dependent
on CYP3A for clearance, and for which elevated plasma concentrations are associated with serious
and/or life-threatening events. These active substances include antiarrhythmics (such as amiodarone,
bepridil, quinidine), antihistamines (such as astemizole, terfenadine), ergot derivatives (such as
dihydroergotamine, ergonovine, ergotamine, methylergonovine), gastrointestinal motility agents (such
as cisapride), antipsychotics (such as pimozide, sertindole, quetiapine, lurasidone), sedatives/hypnotics
(such as orally administered midazolam and triazolam) and HMG-CoA reductase inhibitors (such as
simvastatin and lovastatin) (see section 4.5). Also the use of the alpha-1 adrenoceptor antagonist
alfuzosin, and sildenafil when used for the treatment of pulmonary arterial hypertension. In addition,
co-administration of Aptivus with low dose ritonavir, and medicinal products that are highly
dependent on CYP2D6 for clearance, such as the antiarrhythmics flecainide, propafenone and
metoprolol given in heart failure (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) alfuzosin (HOS-086139) methylergonovine (HOS-086155) propafenone (HOS-084530) cisapride (HOS-085610) lovastatin (HOS-086157) flecainide (HOS-086203) bepridil (HOS-085612) simvastatin (HOS-086158) quinidine (HOS-085593) pimozide (HOS-085600) astemizole (HOS-085608) sildenafil (HOS-086162) ergotamine (HOS-086154) ritonavir (HOS-084521) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) metoprolol (HOS-090094) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Wechselwirkungen · Aptivus
Aptivus 250 mg soft capsules · Abschnitt 4.5 · PDF-Seite 21
HOS-114848 · Präparat HOS-094169
Tipranavir: ↔
Valaciclovir: ↔
Alpha 1-adrenoreceptor antagonists
Alfuzosin Based on theoretical The concomitant use of Aptivus,
considerations, co-administration co-administered with low dose
of tipranavir with low dose ritonavir, with alfuzosin is
ritonavir and alfuzosin results in contraindicated.
increased alfuzosin
concentrations and may result in
hypotension.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) ritonavir (HOS-084521)
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Gegenanzeigen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.3 · PDF-Seite 6
HOS-116288 · Präparat HOS-094447
Darunavir boosted with either ritonavir or cobicistat inhibits the elimination of active substances that
are highly dependent on CYP3A for clearance, which results in increased exposure to the
co-administered medicinal product. Therefore, concomitant treatment with such medicinal products
for which elevated plasma concentrations are associated with serious and/or life-threatening events is
contraindicated (applies to darunavir boosted with either ritonavir or cobicistat). These active
substances include e.g.:
- alfuzosin
- amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine
- astemizole, terfenadine
- colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
- ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine)
- elbasvir/grazoprevir
- cisapride
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin, lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) ticagrelor (HOS-112065) quetiapine (HOS-086150) elbasvir (HOS-108814) alfuzosin (HOS-086139) methylergonovine (HOS-086155) dronedarone (HOS-086144) cisapride (HOS-085610) lovastatin (HOS-086157) lomitapide (HOS-086160) cobicistat (HOS-088111) bepridil (HOS-085612) simvastatin (HOS-086158) quinidine (HOS-085593) domperidone (HOS-114656) avanafil (HOS-086161) naloxegol (HOS-109428) grazoprevir (HOS-108815) ivabradine (HOS-109426) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) sildenafil (HOS-086162) ergotamine (HOS-086154) ritonavir (HOS-084521) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ranolazine (HOS-086141) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Gegenanzeigen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 49
HOS-116497 · Präparat HOS-094447
Co-administration of PREZISTA with low dose ritonavir, with active substances that are highly
dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with
serious and/or life-threatening events. These active substances include e.g.:
- alfuzosin
- amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine
- astemizole, terfenadine
- colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
- ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine)
- elbasvir/grazoprevir
- cisapride
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin and lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) ticagrelor (HOS-112065) quetiapine (HOS-086150) elbasvir (HOS-108814) alfuzosin (HOS-086139) methylergonovine (HOS-086155) dronedarone (HOS-086144) cisapride (HOS-085610) lovastatin (HOS-086157) lomitapide (HOS-086160) bepridil (HOS-085612) simvastatin (HOS-086158) quinidine (HOS-085593) domperidone (HOS-114656) avanafil (HOS-086161) naloxegol (HOS-109428) grazoprevir (HOS-108815) ivabradine (HOS-109426) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) sildenafil (HOS-086162) ergotamine (HOS-086154) ritonavir (HOS-084521) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ranolazine (HOS-086141) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Gegenanzeigen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 87
HOS-116580 · Präparat HOS-094447
Darunavir boosted with either ritonavir or cobicistat inhibits the elimination of active substances that
are highly dependent on CYP3A for clearance, which results in increased exposure to the
co-administered medicinal product. Therefore, concomitant treatment with such medicinal products
for which elevated plasma concentrations are associated with serious and/or life-threatening events is
contraindicated (applies to darunavir boosted with either ritonavir or cobicistat). These active
substances include e.g.:
- alfuzosin
- amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine
- astemizole, terfenadine
- colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
- ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine)
- elbasvir/grazoprevir
- cisapride
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): elbasvir (HOS-108814) alfuzosin (HOS-086139) methylergonovine (HOS-086155) dronedarone (HOS-086144) cisapride (HOS-085610) cobicistat (HOS-088111) bepridil (HOS-085612) quinidine (HOS-085593) grazoprevir (HOS-108815) ivabradine (HOS-109426) colchicine (HOS-086147) astemizole (HOS-085608) ergotamine (HOS-086154) ritonavir (HOS-084521) amiodarone (HOS-085596) terfenadine (HOS-085607) ranolazine (HOS-086141) dihydroergotamine (HOS-086152)
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Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 14–15
HOS-116357 · Präparat HOS-094447
14
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38% ‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of boosted PREZISTA and the
darunavir Cmax ↓ 21%
Lopinavir/ritonavir combination product
lopinavir AUC ↔
533/133.3 mg twice daily lopinavir/ritonavir is
lopinavir Cmin ↑ 13% contraindicated (see section 4.3).
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with boosted
darunavir, ritonavir concentrations were PREZISTA.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
PREZISTA is expected to increase PREZISTA and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with boosted
is mediated via CYP3A, and may as such PREZISTA may require to lower
be inhibited by boosted PREZISTA. the dose of alfentanil and requires
monitoring for risks of prolonged
or delayed respiratory depression.
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. Boosted PREZISTA is Caution is warranted and
Flecainide expected to increase these antiarrhythmic therapeutic concentration
Lidocaine (systemic) plasma concentrations. monitoring, if available, is
Mexiletine (CYP3A and/or CYP2D6 inhibition) recommended for these
Propafenone antiarrhythmics when
co-administered with boosted
PREZISTA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) propafenone (HOS-084530) protease (HOS-085623) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) disopyramide (HOS-085595) maraviroc (HOS-086186) ritonavir (HOS-084521)
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Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 79aee1bbebf74d1fc7eeb1f64d47f744ae971edc2caad3984bd946f3f467a703 · Zeichen 24118–27577 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 56
HOS-116515 · Präparat HOS-094447
Saquinavir: comparison of
saquinavir/ritonavir 1,000/100 mg twice
daily vs. saquinavir/darunavir/ritonavir
1,000/400/100 mg twice daily
Darunavir: comparison of
darunavir/ritonavir 400/100 mg twice
daily vs. darunavir/ritonavir 400/100 mg
in combination with saquinavir 1,000 mg
twice daily.
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38%‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of PREZISTA co-administered
darunavir Cmax ↓ 21%
with low dose ritonavir and the
lopinavir AUC ↔
Lopinavir/ritonavir combination product
533/133.3 mg twice daily lopinavir Cmin ↑ 13% lopinavir/ritonavir is
lopinavir Cmax ↑ 11% contraindicated (see section 4.3).
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with PREZISTA
darunavir, ritonavir concentrations were with low dose ritonavir.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of PREZISTA
PREZISTA is expected to increase with low dose ritonavir and
alfuzosin plasma concentrations. alfuzosin is contraindicated (see
(CYP3A inhibition) section 4.3).
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with
is mediated via CYP3A, and may as such PREZISTA and low dose ritonavir
be inhibited by PREZISTA may require to lower the dose of
co-administered with low dose ritonavir. alfentanil and requires monitoring
for risks of prolonged or delayed
respiratory depression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) protease (HOS-085623) saquinavir (HOS-084522) maraviroc (HOS-086186) ritonavir (HOS-084521)
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Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage fee9104200efc5fedbf726f44b3ea40b4fea72494f0de60d64ad635836e51d2d · Zeichen 16855–20345 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 95–96
HOS-116606 · Präparat HOS-094447
95
Saquinavir # It is not recommended to combine
darunavir AUC ↓ 26%
1,000 mg twice daily #
darunavir Cmin ↓ 42% PREZISTA co-administered with
#
darunavir Cmax ↓ 17% low dose ritonavir with saquinavir.
saquinavir AUC ↓ 6%
saquinavir Cmin ↓ 18% PREZISTA co-administered with
cobicistat should not be used in
saquinavir Cmax ↓ 6%
combination with another
antiretroviral agent that requires
Saquinavir: comparison of
pharmacoenhancement by means
saquinavir/ritonavir 1,000/100 mg twice
of co-administration with an
daily vs. saquinavir/darunavir/ritonavir
inhibitor of CYP3A4 (see section
1,000/400/100 mg twice daily
4.5).
Darunavir: comparison of
darunavir/ritonavir 400/100 mg twice
daily vs. darunavir/ritonavir 400/100 mg
in combination with saquinavir 1,000 mg
twice daily.
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38%‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of boosted PREZISTA and the
darunavir Cmax ↓ 21%
Lopinavir/ritonavir combination product
lopinavir AUC ↔
533/133.3 mg twice daily lopinavir/ritonavir is
lopinavir Cmin ↑ 13% contraindicated (see section 4.3).
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with boosted
darunavir, ritonavir concentrations were PREZISTA.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
PREZISTA is expected to increase PREZISTA and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with boosted
is mediated via CYP3A, and may as such PREZISTA may require to lower
be inhibited by boosted PREZISTA. the dose of alfentanil and requires
monitoring for risks of prolonged
or delayed respiratory depression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) protease (HOS-085623) cobicistat (HOS-088111) saquinavir (HOS-084522) maraviroc (HOS-086186) ritonavir (HOS-084521)
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Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 1eb808e8ac29f3c76db8fe318c2ee85ee0f022f66cbb4ebf8bdc633036fd5092 · Zeichen 22422–27069 im Abschnitt
Wechselwirkungen · Adcirca (previously Tadalafil Lilly)
ADCIRCA 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7
HOS-210083 · Präparat HOS-154449
In interaction studies performed in a limited number of healthy volunteers, these effects were not
reported with alfuzosin or tamsulosin.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) tamsulosin (HOS-111257)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-27T15:17:00Z · SHA-256 f45503711a580d9fd5973be63b2c67b7830a1e53d77892c603581b2f6ee084ab · Passage 2d2746e4b9b9d4cdb59b98dbb1a752d70008f68450854d100b319825ebea9b35 · Zeichen 2502–2639 im Abschnitt
Wechselwirkungen · Adcirca (previously Tadalafil Lilly)
ADCIRCA 2 mg/mL oral suspension · Abschnitt 4.5 · PDF-Seite 24
HOS-210138 · Präparat HOS-154449
In interaction studies performed in a limited number of healthy volunteers, these effects were not
reported with alfuzosin or tamsulosin.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) tamsulosin (HOS-111257)
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Version 2026-01-27T15:17:00Z · SHA-256 f45503711a580d9fd5973be63b2c67b7830a1e53d77892c603581b2f6ee084ab · Passage 2d2746e4b9b9d4cdb59b98dbb1a752d70008f68450854d100b319825ebea9b35 · Zeichen 2501–2638 im Abschnitt
Wechselwirkungen · Akynzeo
Akynzeo 235 mg/0.25 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 22
HOS-130746 · Präparat HOS-096947
Akynzeo contains a 5-HT3 receptor antagonist, palonosetron that may increase QT interval
prolongation. Therefore, caution should be exercised in concomitant use with medicinal products that
increase the QT interval, including but not limited to: levofloxacine, amytriptyline, alfuzosin,
azythromicin, arsenic trioxide (see section 4.4).
Furthermore, caution is advised in case of fosnetupitant/palonosetron concomitantly with medicinal
products known to induce hypokalaemia, such as ampicillin, albuterol, terbutaline, furosemide,
thiazides, or medicinal products known to induce bradycardia, such as beta blockers, verapamil,
diltiazem, digitalis, and antiarrhythmics. .
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): furosemide (HOS-089060) albuterol (HOS-130750) diltiazem (HOS-086288) arsenic trioxide (HOS-109648) ampicillin (HOS-088383) alfuzosin (HOS-086139) fosnetupitant (HOS-130728) terbutaline (HOS-085475) verapamil (HOS-090602)
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Version 2026-08-25T11:52:00Z · SHA-256 d3ff78e9e4d5b08bc98e527fab724082b02f5be1899a4d4f9c683d723854e46c · Passage 1698d1fea8a8e213b448aa10eab1e47ac595ff9b21fd0ca9c1b8801617253e33 · Zeichen 6918–7589 im Abschnitt
Wechselwirkungen · Akynzeo
Akynzeo 235 mg/0.25 mg concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 40
HOS-130788 · Präparat HOS-096947
Akynzeo contains a 5-HT3 receptor antagonist, palonosetron that may increase QT interval
prolongation. Therefore, caution should be exercised in concomitant use with medicinal products that
increase the QT interval, including but not limited to: levofloxacine, amytriptyline, alfuzosin,
azythromicin, arsenic trioxide (see section 4.4).
Furthermore, caution is advised in case of fosnetupitant/palonosetron concomitantly with medicinal
products known to induce hypokalaemia, such as ampicillin, albuterol, terbutaline, furosemide,
thiazides, or medicinal products known to induce bradycardia, such as beta blockers, verapamil,
diltiazem, digitalis and antiarrhythmics.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): furosemide (HOS-089060) albuterol (HOS-130750) diltiazem (HOS-086288) arsenic trioxide (HOS-109648) ampicillin (HOS-088383) alfuzosin (HOS-086139) fosnetupitant (HOS-130728) terbutaline (HOS-085475) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-25T11:52:00Z · SHA-256 d3ff78e9e4d5b08bc98e527fab724082b02f5be1899a4d4f9c683d723854e46c · Passage f228b4ab0fbfe7d5e9d17e27379eaf206ced5161198b9da8558331efbaff4c33 · Zeichen 6908–7576 im Abschnitt
Wechselwirkungen · Tadalafil Mylan
Tadalafil Mylan 2.5 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6
HOS-131383 · Präparat HOS-097067
Anti-hypertensives (including calcium channel blockers)
The co-administration of doxazosin (4 and 8 mg daily) and tadalafil (5 mg daily dose and 20 mg as a single
dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect
lasts at least twelve hours and may be symptomatic, including syncope. Therefore this combination is not
recommended (see section 4.4).
In interaction studies performed in a limited number of healthy volunteers, these effects were not reported
with alfuzosin or tamsulosin. However, caution should be exercised when using tadalafil in patients treated
with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and
progressively adjusted.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) doxazosin (HOS-088800) calcium (HOS-085615) tamsulosin (HOS-111257)
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Version 2026-06-15T12:38:00Z · SHA-256 2c06d7b4e73c05361baf5d12e4bb06aa9f06b0ce1a899ac34068fb6b554e7343 · Passage c3c3d88656ecc7871d91497d3c32df63d4e2516ff6ce69cf832c78c00752eb7e · Zeichen 2954–3708 im Abschnitt
Wechselwirkungen · Tadalafil Mylan
Tadalafil Mylan 5 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 20
HOS-131432 · Präparat HOS-097067
Anti-hypertensives (including calcium channel blockers)
The co-administration of doxazosin (4 and 8 mg daily) and tadalafil (5 mg daily dose and 20 mg as a single
dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect
lasts at least twelve hours and may be symptomatic, including syncope. Therefore this combination is not
recommended (see section 4.4).
In interaction studies performed in a limited number of healthy volunteers, these effects were not reported
with alfuzosin or tamsulosin. However, caution should be exercised when using tadalafil in patients treated
with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and
progressively adjusted.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) doxazosin (HOS-088800) calcium (HOS-085615) tamsulosin (HOS-111257)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-15T12:38:00Z · SHA-256 2c06d7b4e73c05361baf5d12e4bb06aa9f06b0ce1a899ac34068fb6b554e7343 · Passage c3c3d88656ecc7871d91497d3c32df63d4e2516ff6ce69cf832c78c00752eb7e · Zeichen 2894–3648 im Abschnitt
Wechselwirkungen · Tadalafil Mylan
Tadalafil Mylan 10 mg film-coated tablets Tadalafil Mylan 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 35
HOS-131478 · Präparat HOS-097067
Anti-hypertensives (including calcium channel blockers)
The co-administration of doxazosin (4 and 8 mg daily) and tadalafil (5 mg daily dose and 20 mg as a single
dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect
lasts at least twelve hours and may be symptomatic, including syncope. Therefore this combination is not
recommended (see section 4.4).
In interaction studies performed in a limited number of healthy volunteers, these effects were not reported
with alfuzosin or tamsulosin. However, caution should be exercised when using tadalafil in patients treated
with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and
progressively adjusted.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) doxazosin (HOS-088800) calcium (HOS-085615) tamsulosin (HOS-111257)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-15T12:38:00Z · SHA-256 2c06d7b4e73c05361baf5d12e4bb06aa9f06b0ce1a899ac34068fb6b554e7343 · Passage c3c3d88656ecc7871d91497d3c32df63d4e2516ff6ce69cf832c78c00752eb7e · Zeichen 2952–3706 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.