Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Gegenanzeigen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.3 · PDF-Seite 4
HOS-086138 · Präparat HOS-083284
Concomitant medicinal product levels increased or decreased
1-Adrenoreceptor Alfuzosin Increased plasma concentrations of alfuzosin
Antagonist which may lead to severe hypotension (see
section 4.5).
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecanide,
encainide, flecanide, propafenone, quinidine. Thereby, increasing the
propafenone, quinidine risk of arrhythmias or other serious adverse
reactions from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): propoxyphene (HOS-086140) quetiapine (HOS-086150) encainide (HOS-086145) alfuzosin (HOS-086139) propafenone (HOS-084530) dronedarone (HOS-086144) fusidic acid (HOS-086146) bepridil (HOS-085612) quinidine (HOS-085593) neratinib (HOS-086142) venetoclax (HOS-086143) lead (HOS-085592) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) clozapine (HOS-086149) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ranolazine (HOS-086141)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f9fe97979894eedcce9660008265f9fc818cdb3984974bb2555b6c5e5869e4e5 · Zeichen 902–5292 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 35–36
HOS-086388 · Präparat HOS-083284
35
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecainide,
encainide, flecainide, propafenone, quinidine. Thereby, increasing
propafenone, quinidine the risk of arrhythmias or other serious adverse
effects from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Ergot Derivatives Dihydroergotamine, Increased plasma concentrations of ergot
ergonovine, derivatives leading to acute ergot toxicity,
ergotamine, including vasospasm and ischaemia.
methylergonovine
GI motility agent Cisapride Increased plasma concentrations of cisapride.
Thereby, increasing the risk of serious
arrhythmias from this agent.
Lipid-modifying agents
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): propoxyphene (HOS-086140) quetiapine (HOS-086150) encainide (HOS-086145) methylergonovine (HOS-086155) propafenone (HOS-084530) dronedarone (HOS-086144) cisapride (HOS-085610) fusidic acid (HOS-086146) flecainide (HOS-086203) bepridil (HOS-085612) quinidine (HOS-085593) neratinib (HOS-086142) venetoclax (HOS-086143) lead (HOS-085592) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) clozapine (HOS-086149) ergotamine (HOS-086154) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ranolazine (HOS-086141) ergonovine (HOS-086153) dihydroergotamine (HOS-086152)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f76b82bf2af9e33f5778d35af3ff4a8ea2ea8d392666af7950204db67ec4ac88 · Zeichen 1234–5743 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 18
HOS-086282 · Präparat HOS-083284
Lurasidone Due to CYP3A inhibition by ritonavir, concentrations of lurasidone are expected to
increase. The concomitant administration with lurasidone is contraindicated (see
section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lurasidone (HOS-086148)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 0b2cddd70a9d0e6e84f198bdfb2c2d8fddadfcdf329efa4d0cb73db5d20d076e · Zeichen 38292–38592 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 51
HOS-086460 · Präparat HOS-083284
Lurasidone Due to CYP3A inhibition by ritonavir, concentrations of lurasidone are expected to
increase. The concomitant administration with lurasidone is contraindicated (see section
4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lurasidone (HOS-086148)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 9a901670059096c3f491f539bb11730c25bd259aea37f3ebe13a675f7bc6cec8 · Zeichen 40083–40383 im Abschnitt
Gegenanzeigen · Kaletra
Kaletra (80 mg + 20 mg) / ml oral solution · Abschnitt 4.3 · PDF-Seite 5
HOS-108791 · Präparat HOS-093083
Concomitant medicinal product levels increased
Alpha1-adrenoreceptor Alfuzosin Increased plasma concentrations of
antagonist alfuzosin which may lead to severe
hypotension. The concomitant
administration with alfuzosin is
contraindicated (see section 4.5).
Antianginal Ranolazine Increased plasma concentrations of
ranolazine which may increase the
potential for serious and/or life-
threatening reactions (see section 4.5).
Antiarrhythmics Amiodarone, dronedarone Increased plasma concentrations of
amiodarone and dronedarone. Thereby,
increasing the risk of arrhythmias or
other serious adverse reactions (see
section 4.5).
Antibiotic Fusidic Acid Increased plasma concentrations of
fusidic acid. The concomitant
administration with fusidic acid is
contraindicated in dermatological
infections (see section 4.5).
Anticancer Neratinib Increased plasma concentrations of
neratinib which may increase the
potential for serious and/or
life-threatening reactions (see section
4.5).
Venetoclax Increased plasma concentrations of
venetoclax. Increased risk of tumor lysis
syndrome at the dose initiation and
during the ramp-up phase (see section
4.5).
Anti-gout Colchicine Increased plasma concentrations of
colchicine. Potential for serious and/or
life-threatening reactions in patients with
renal and/or hepatic impairment (see
sections 4.4 and 4.5).
Antihistamines Astemizole, terfenadine Increased plasma concentrations of
astemizole and terfenadine. Thereby,
increasing the risk of serious
arrhythmias from these agents (see
section 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of
Neuroleptics lurasidone which may increase the
potential for serious and/or life-
threatening reactions (see section 4.5).
Pimozide Increased plasma concentrations of
pimozide. Thereby, increasing the risk
of serious haematologic abnormalities,
or other serious adverse effects from this
agent (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) dronedarone (HOS-086144) fusidic acid (HOS-086146) neratinib (HOS-086142) venetoclax (HOS-086143) lead (HOS-085592) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) amiodarone (HOS-085596) terfenadine (HOS-085607) lurasidone (HOS-086148) ranolazine (HOS-086141)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage 3af5f7da19ec49492414676af6b40d10b1389f87518dc00840ff964623d97870 · Zeichen 617–4755 im Abschnitt
Gegenanzeigen · Kaletra
Kaletra 200 mg/50 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 42–43
HOS-108988 · Präparat HOS-093083
42
Antihistamines Astemizole, terfenadine Increased plasma concentrations of
astemizole and terfenadine. Thereby,
increasing the risk of serious
arrhythmias from these agents (see
section 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of
Neuroleptics lurasidone which may increase the
potential for serious and/or life-
threatening reactions (see section 4.5).
Pimozide Increased plasma concentrations of
pimozide. Thereby, increasing the risk
of serious haematologic abnormalities,
or other serious adverse effects from
this agent (see section 4.5).
Quetiapine Increased plasma concentrations of
quetiapine which may lead to coma.
The concomitant administration with
quetiapine is contraindicated (see
section 4.5).
Ergot alkaloids Dihydroergotamine, ergonovine, Increased plasma concentrations of
ergotamine, methylergonovine ergot derivatives leading to acute ergot
toxicity, including vasospasm and
ischaemia (see section 4.5).
GI motility agent Cisapride Increased plasma concentrations of
cisapride. Thereby, increasing the risk
of serious arrhythmias from this agent
(see section 4.5).
Hepatitis C virus Elbasvir/grazoprevir Increased risk of alanine transaminase
direct acting antivirals (ALT) elevations (see section 4.5).
Lipid-modifying agents
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) elbasvir (HOS-108814) methylergonovine (HOS-086155) cisapride (HOS-085610) hepatitis C virus (HOS-108813) ergot alkaloids (HOS-108807) lead (HOS-085592) grazoprevir (HOS-108815) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) dihydroergotamine (HOS-086152) alanine (HOS-088949)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage 513868d9cbc220f8b16283ba405e7ae3a7eba9be191b93bb320faa5cdf17028c · Zeichen 3976–6635 im Abschnitt
Gegenanzeigen · Kaletra
Kaletra 100 mg/25 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 77–78
HOS-109062 · Präparat HOS-093083
77
Venetoclax Increased plasma concentrations of
venetoclax. Increased risk of tumor lysis
syndrome at the dose initiation and during
the ramp-up phase (see section 4.5).
Anti-gout Colchicine Increased plasma concentrations of
colchicine. Potential for serious and/or
life-threatening reactions in patients with
renal and/or hepatic impairment (see
sections 4.4 and 4.5).
Antihistamines Astemizole, terfenadine Increased plasma concentrations of
astemizole and terfenadine. Thereby,
increasing the risk of serious arrhythmias
from these agents (see section 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of
Neuroleptics lurasidone which may increase the
potential for serious and/or life-
threatening reactions (see section 4.5).
Pimozide Increased plasma concentrations of
pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or
other serious adverse effects from this
agent (see section 4.5).
Quetiapine Increased plasma concentrations of
quetiapine which may lead to coma. The
concomitant administration with
quetiapine is contraindicated (see section
4.5).
Ergot alkaloids Dihydroergotamine, ergonovine, Increased plasma concentrations of ergot
ergotamine, methylergonovine derivatives leading to acute ergot toxicity,
including vasospasm and ischaemia (see
section 4.5).
GI motility agent Cisapride Increased plasma concentrations of
cisapride. Thereby, increasing the risk of
serious arrhythmias from this agent (see
section 4.5).
Hepatitis C virus direct Elbasvir/grazoprevir Increased risk of alanine transaminase
acting antivirals (ALT) elevations (see section 4.5).
Lipid-modifying agents
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) elbasvir (HOS-108814) methylergonovine (HOS-086155) cisapride (HOS-085610) hepatitis C virus (HOS-108813) ergot alkaloids (HOS-108807) venetoclax (HOS-086143) lead (HOS-085592) grazoprevir (HOS-108815) pimozide (HOS-085600) colchicine (HOS-086147) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) dihydroergotamine (HOS-086152) alanine (HOS-088949)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage deedafd686f2a7856b9535fd14424479a75da74b88007e447ddb2a759abcc3fe · Zeichen 2941–6504 im Abschnitt
Wechselwirkungen · Kaletra
Kaletra (80 mg + 20 mg) / ml oral solution · Abschnitt 4.5 · PDF-Seite 19–20
HOS-108904 · Präparat HOS-093083
19
Rifampicin Lopinavir: Co-administration of Kaletra with
Large decreases in lopinavir rifampicin is not recommended as
concentrations may be observed the decrease in lopinavir
due to CYP3A induction by concentrations may in turn
rifampicin. significantly decrease the lopinavir
therapeutic effect. A dose
adjustment of Kaletra
400 mg/400 mg (i.e. Kaletra
400/100 mg + ritonavir 300 mg)
twice daily has allowed
compensating for the CYP 3A4
inducer effect of rifampicin.
However, such a dose adjustment
might be associated with ALT/AST
elevations and with increase in
gastrointestinal disorders.
Therefore, this co-administration
should be avoided unless judged
strictly necessary. If this
co-administration is judged
unavoidable, increased dose of
Kaletra at 400 mg/400 mg twice
daily may be administered with
rifampicin under close safety and
therapeutic drug monitoring. The
Kaletra dose should be titrated
upward only after rifampicin has
been initiated (see section 4.4).
Antipsychotics
Lurasidone Due to CYP3A inhibition by The concomitant administration
lopinavir/ritonavir, with lurasidone is contraindicated
concentrations of lurasidone are (see section 4.3).
expected to increase.
Pimozide Due to CYP3A inhibition by Concomitant administration of
lopinavir/ritonavir, Kaletra and pimozide is
concentrations of pimozide are contraindicated as it may increase
expected to increase. the risk of serious haematologic
abnormalities or other serious
adverse effects from this agent (see
section 4.3)
Quetiapine Due to CYP3A inhibition by Concomitant administration of
lopinavir/ritonavir, Kaletra and quetiapine is
concentrations of quetiapine are contraindicated as it may increase
expected to increase. quetiapine-related toxicity.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) pimozide (HOS-085600) lurasidone (HOS-086148)
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Wechselwirkungen · Kaletra
Kaletra 200 mg/50 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 55–56
HOS-109015 · Präparat HOS-093083
55
Rifampicin Lopinavir: Co-administration of Kaletra with
Large decreases in lopinavir rifampicin is not recommended as
concentrations may be observed the decrease in lopinavir
due to CYP3A induction by concentrations may in turn
rifampicin. significantly decrease the lopinavir
therapeutic effect. A dose adjustment
of Kaletra 400 mg/400 mg (i.e.
Kaletra 400/100 mg + ritonavir
300 mg) twice daily has allowed
compensating for the CYP 3A4
inducer effect of rifampicin.
However, such a dose adjustment
might be associated with ALT/AST
elevations and with increase in
gastrointestinal disorders. Therefore,
this co-administration should be
avoided unless judged strictly
necessary. If this co-administration is
judged unavoidable, increased dose
of Kaletra at 400 mg/400 mg twice
daily may be administered with
rifampicin under close safety and
therapeutic drug monitoring. The
Kaletra dose should be titrated
upward only after rifampicin has been
initiated (see section 4.4).
Antipsychotics
Lurasidone Due to CYP3A inhibition by The concomitant administration with
lopinavir/ritonavir, concentrations lurasidone is contraindicated (see
of lurasidone are expected to section 4.3).
increase.
Pimozide Due to CYP3A inhibition by Concomitant administration of
lopinavir/ritonavir, concentrations Kaletra and pimozide is
of pimozide are expected to contraindicated as it may increase the
increase. risk of serious haematologic
abnormalities or other serious
adverse effects from this agent (see
section 4.3)
Quetiapine Due to CYP3A inhibition by Concomitant administration of
lopinavir/ritonavir, concentrations Kaletra and quetiapine is
of quetiapine are expected to contraindicated as it may increase
increase. quetiapine-related toxicity.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) pimozide (HOS-085600) lurasidone (HOS-086148)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage c8939a16b64f6d8ec4a19ded0cb5af8a6d3c243259de96cb30a89f8088ddcbc4 · Zeichen 37143–40650 im Abschnitt
Wechselwirkungen · Kaletra
Kaletra 100 mg/25 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 90–91
HOS-109091 · Präparat HOS-093083
90
Rifabutin, 150 mg QD Rifabutin (parent drug and active When given with Kaletra the
25-O-desacetyl metabolite): recommended dose of rifabutin is
AUC: ↑ 5.7-fold 150 mg 3 times per week on set
Cmax: ↑ 3.5-fold days (for example Monday-
Wednesday-Friday). Increased
monitoring for rifabutin-associated
adverse reactions including
neutropenia and uveitis is warranted
due to an expected increase in
exposure to rifabutin. Further
dosage reduction of rifabutin to
150 mg twice weekly on set days is
recommended for patients in whom
the 150 mg dose 3 times per week is
not tolerated. It should be kept in
mind that the twice weekly dosage
of 150 mg may not provide an
optimal exposure to rifabutin thus
leading to a risk of rifamycin
resistance and a treatment failure.
No dose adjustment is needed for
Kaletra.
Rifampicin Lopinavir: Co-administration of Kaletra with
Large decreases in lopinavir rifampicin is not recommended as
concentrations may be observed the decrease in lopinavir
due to CYP3A induction by concentrations may in turn
rifampicin. significantly decrease the lopinavir
therapeutic effect. A dose
adjustment of Kaletra
400 mg/400 mg (i.e. Kaletra
400/100 mg + ritonavir 300 mg)
twice daily has allowed
compensating for the CYP 3A4
inducer effect of rifampicin.
However, such a dose adjustment
might be associated with ALT/AST
elevations and with increase in
gastrointestinal disorders.
Therefore, this co-administration
should be avoided unless judged
strictly necessary. If this
co-administration is judged
unavoidable, increased dose of
Kaletra at 400 mg/400 mg twice
daily may be administered with
rifampicin under close safety and
therapeutic drug monitoring. The
Kaletra dose should be titrated
upward only after rifampicin has
been initiated (see section 4.4).
Antipsychotics
Lurasidone Due to CYP3A inhibition by The concomitant administration
lopinavir/ritonavir, concentrations with lurasidone is contraindicated
of lurasidone are expected to (see section 4.3).
increase.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): rifabutin (HOS-086262) lurasidone (HOS-086148)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage ef631cb168a202ad49cd1e5d830eb707073235478031c2a079706957841b1d31 · Zeichen 35398–40311 im Abschnitt
Gegenanzeigen · Vfend
VFEND 50 mg film-coated tablets VFEND 200 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 5
HOS-109425 · Präparat HOS-093201
• Terfenadine
• Astemizole
• Cisapride
• Pimozide
• Lurasidone
• Quinidine
• Ivabradine
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine)
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cisapride (HOS-085610) quinidine (HOS-085593) ergot alkaloids (HOS-108807) ivabradine (HOS-109426) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) dihydroergotamine (HOS-086152)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 92d039d4c373d2ccbb0905dc4377f6a8efd63303319839f8da1593b24c1c81cc · Zeichen 515–724 im Abschnitt
Gegenanzeigen · Vfend
VFEND 200 mg powder for solution for infusion · Abschnitt 4.3 · PDF-Seite 36
HOS-109524 · Präparat HOS-093201
• Terfenadine
• Astemizole
• Cisapride
• Pimozide
• Lurasidone
• Quinidine
• Ivabradine
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine)
• Sirolimus
• Naloxegol
• Tolvaptan
• Finerenone
• Eplerenone
• Voclosporin
• Venetoclax: Coadministration contraindicated at initiation and during venetoclax dose titration
phase.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cisapride (HOS-085610) eplerenone (HOS-089050) quinidine (HOS-085593) finerenone (HOS-109430) tolvaptan (HOS-109429) ergot alkaloids (HOS-108807) venetoclax (HOS-086143) naloxegol (HOS-109428) ivabradine (HOS-109426) pimozide (HOS-085600) astemizole (HOS-085608) sirolimus (HOS-085172) voclosporin (HOS-109432) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) dihydroergotamine (HOS-086152)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 392392b9fe6da7258d9d0da5625b43e73df89387373d420d8ae08c8a730299d2 · Zeichen 515–979 im Abschnitt
Gegenanzeigen · Vfend
VFEND 40 mg/ml powder for oral suspension · Abschnitt 4.3 · PDF-Seite 69
HOS-109587 · Präparat HOS-093201
• Terfenadine
• Astemizole
• Cisapride
• Pimozide
• Lurasidone
• Quinidine
• Ivabradine
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine)
• Sirolimus
• Naloxegol
• Tolvaptan
• Finerenone
• Eplerenone
• Voclosporin
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cisapride (HOS-085610) eplerenone (HOS-089050) quinidine (HOS-085593) finerenone (HOS-109430) tolvaptan (HOS-109429) ergot alkaloids (HOS-108807) naloxegol (HOS-109428) ivabradine (HOS-109426) pimozide (HOS-085600) astemizole (HOS-085608) sirolimus (HOS-085172) voclosporin (HOS-109432) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) dihydroergotamine (HOS-086152)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 52e206f10d0171fc7c859121398e23adfe815eb2cdb7b4fd04fb205bc3c3bde3 · Zeichen 515–854 im Abschnitt
Wechselwirkungen · Vfend
VFEND 50 mg film-coated tablets VFEND 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 14
HOS-109467 · Präparat HOS-093201
Compared to efavirenz 600 mg Voriconazole may be
QD, coadministered with efavirenz if
Efavirenz 300 mg QD, Efavirenz Cmax ↔ the voriconazole maintenance
coadministered with Efavirenz AUC 17% dose is increased to 400 mg BID
voriconazole 400 mg BID* and the efavirenz dose is
Compared to voriconazole 200 mg decreased to 300 mg QD. When
BID, voriconazole treatment is
Voriconazole Cmax 23% stopped, the initial dose of
efavirenz should be restored (see
Voriconazole AUC 7%
sections 4.2 and 4.4).
Other Non-Nucleoside Reverse Not studied clinically. In vitro Careful monitoring for any
Transcriptase Inhibitors studies show that the metabolism occurrence of drug toxicity
(NNRTIs) (including but not of voriconazole may be inhibited and/or lack of efficacy, and dose
limited to: delavirdine, by NNRTIs and voriconazole may adjustment may be needed.
nevirapine)* inhibit the metabolism of NNRTIs.
[CYP3A4 substrates, inhibitors The findings of the effect of
or CYP450 inducers] efavirenz on voriconazole suggest
that the metabolism of
voriconazole may be induced by an
NNRTI.
Antipsychotics
Lurasidone Although not studied, Contraindicated (see section
[CYP3A4 substrate] voriconazole is likely to 4.3)
significantly increase the plasma
concentrations of lurasidone.
Pimozide Although not studied, increased Contraindicated (see section
[CYP3A4 substrate] plasma concentrations of pimozide 4.3)
can lead to QTc prolongation and
rare occurrences of torsades de
pointes.
Anti virals
Letermovir Voriconazole Cmax ↓ 39% If concomitant administration of
[CYP2C9 and CYP2C19 Voriconazole AUC0-12 ↓ 44% voriconazole with letermovir
inducer] Voriconazole C12 ↓ 51% cannot be avoided, monitor for
loss of voriconazole
effectiveness.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): letermovir (HOS-090621) lead (HOS-085592) pimozide (HOS-085600) efavirenz (HOS-087947) delavirdine (HOS-109468) nevirapine (HOS-088064) lurasidone (HOS-086148)
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Wechselwirkungen · Vfend
VFEND 200 mg powder for solution for infusion · Abschnitt 4.5 · PDF-Seite 45–46
HOS-109544 · Präparat HOS-093201
45
Other Non-Nucleoside Reverse Not studied clinically. In vitro Careful monitoring for any
Transcriptase Inhibitors studies show that the metabolism occurrence of drug toxicity
(NNRTIs) (including but not of voriconazole may be inhibited and/or lack of efficacy, and dose
limited to: delavirdine, by NNRTIs and voriconazole may adjustment may be needed.
nevirapine)* inhibit the metabolism of NNRTIs.
[CYP3A4 substrates, inhibitors The findings of the effect of
or CYP450 inducers] efavirenz on voriconazole suggest
that the metabolism of
voriconazole may be induced by an
NNRTI.
Antipsychotics
Lurasidone Although not studied, Contraindicated (see section
[CYP3A4 substrate] voriconazole is likely to 4.3)
significantly increase the plasma
concentrations of lurasidone.
Pimozide Although not studied, increased Contraindicated (see section
[CYP3A4 substrate] plasma concentrations of pimozide 4.3)
can lead to QTc prolongation and
rare occurrences of torsades de
pointes.
Anti virals
Letermovir Voriconazole Cmax ↓ 39% If concomitant administration of
[CYP2C9 and CYP2C19 Voriconazole AUC0-12 ↓ 44% voriconazole with letermovir
inducer] Voriconazole C12 ↓ 51% cannot be avoided, monitor for
loss of voriconazole
effectiveness.
Benzodiazepines
[CYP3A4 substrates] Dose reduction of
Midazolam (0.05 mg/kg IV In an independent published study, benzodiazepines should be
single dose) Midazolam AUC0- 3.7-fold considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): letermovir (HOS-090621) lead (HOS-085592) pimozide (HOS-085600) efavirenz (HOS-087947) delavirdine (HOS-109468) nevirapine (HOS-088064) lurasidone (HOS-086148) midazolam (HOS-086167)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage ef43a168f9ab76fd2a9647a23dc50db8759604cb80a4b6eb2684eff57e70dd70 · Zeichen 18658–20764 im Abschnitt
Wechselwirkungen · Vfend
VFEND 40 mg/ml powder for oral suspension · Abschnitt 4.5 · PDF-Seite 78
HOS-109609 · Präparat HOS-093201
Voriconazole may be
Compared to efavirenz 600 mg coadministered with efavirenz if
Efavirenz 300 mg QD, QD, the voriconazole maintenance
coadministered with Efavirenz Cmax ↔ dose is increased to 400 mg BID
voriconazole 400 mg BID* Efavirenz AUC 17% and the efavirenz dose is
decreased to 300 mg QD. When
Compared to voriconazole 200 mg voriconazole treatment is
BID, stopped, the initial dose of
Voriconazole Cmax 23% efavirenz should be restored (see
sections 4.2 and 4.4).
Voriconazole AUC 7%
Other Non-Nucleoside Reverse Not studied clinically. In vitro Careful monitoring for any
Transcriptase Inhibitors studies show that the metabolism occurrence of drug toxicity
(NNRTIs) (including but not of voriconazole may be inhibited and/or lack of efficacy, and dose
limited to: delavirdine, by NNRTIs and voriconazole may adjustment may be needed.
nevirapine)* inhibit the metabolism of NNRTIs.
[CYP3A4 substrates, inhibitors The findings of the effect of
or CYP450 inducers] efavirenz on voriconazole suggest
that the metabolism of
voriconazole may be induced by an
NNRTI.
Antipsychotics
Lurasidone Although not studied, Contraindicated (see section
[CYP3A4 substrate] voriconazole is likely to 4.3)
significantly increase the plasma
concentrations of lurasidone.
Pimozide Although not studied, increased Contraindicated (see section
[CYP3A4 substrate] plasma concentrations of pimozide 4.3)
can lead to QTc prolongation and
rare occurrences of torsades de
pointes.
Anti virals
Letermovir Voriconazole Cmax ↓ 39% If concomitant administration of
[CYP2C9 and CYP2C19 Voriconazole AUC0-12 ↓ 44% voriconazole with letermovir
inducer] Voriconazole C12 ↓ 51% cannot be avoided, monitor for
loss of voriconazole
effectiveness.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): letermovir (HOS-090621) lead (HOS-085592) pimozide (HOS-085600) efavirenz (HOS-087947) delavirdine (HOS-109468) nevirapine (HOS-088064) lurasidone (HOS-086148)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage c70898b80fc99d5c7ad2c1cde8f7ced3883c2049c59d6e28694b98f03f2f260e · Zeichen 17288–20027 im Abschnitt
Gegenanzeigen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.3 · PDF-Seite 4
HOS-112044 · Präparat HOS-093615
Co-administration with medicinal products that are substrates of the CYP3A4 isoform of cytochrome
P450 and have narrow therapeutic windows (e.g., quetiapine, lurasidone, alfuzosin, astemizole,
terfenadine, cisapride, pimozide, quinidine, bepridil, triazolam, midazolam administered orally (for
caution on parenterally administered midazolam, see section 4.5), lomitapide, and ergot alkaloids,
particularly, ergotamine, dihydroergotamine, ergonovine, methylergonovine) (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) alfuzosin (HOS-086139) methylergonovine (HOS-086155) cisapride (HOS-085610) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) ergot alkaloids (HOS-108807) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Gegenanzeigen · Reyataz
REYATAZ 50 mg oral powder · Abschnitt 4.3 · PDF-Seite 40
HOS-112152 · Präparat HOS-093615
Co-administration with medicinal products that are substrates of the CYP3A4 isoform of cytochrome
P450 and have narrow therapeutic windows (e.g., quetiapine, alfuzosin, astemizole, terfenadine,
cisapride, pimozide, quinidine, lurasidone, bepridil, triazolam, midazolam administered orally (for
caution on parenterally administered midazolam, see section 4.5), lomitapide and ergot alkaloids,
particularly, ergotamine, dihydroergotamine, ergonovine, methylergonovine) (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) alfuzosin (HOS-086139) methylergonovine (HOS-086155) cisapride (HOS-085610) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) ergot alkaloids (HOS-108807) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) ergonovine (HOS-086153) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-112050 · Präparat HOS-093615
Atazanavir is metabolised in the liver through CYP3A4. It inhibits CYP3A4. Therefore, REYATAZ is
contraindicated with medicinal products that are substrates of CYP3A4 and have a narrow therapeutic
index: quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine,
bepridil, triazolam, orally administered midazolam, lomitapide, and ergot alkaloids, particularly
ergotamine and dihydroergotamine (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) alfuzosin (HOS-086139) cisapride (HOS-085610) lomitapide (HOS-086160) bepridil (HOS-085612) quinidine (HOS-085593) ergot alkaloids (HOS-108807) pimozide (HOS-085600) astemizole (HOS-085608) ergotamine (HOS-086154) terfenadine (HOS-085607) lurasidone (HOS-086148) triazolam (HOS-086168) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
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Version 2026-06-29T13:00:00Z · SHA-256 ff5481974bd7c752b73fa0c147cf3e96fc892edc735359fa71817833db471beb · Passage 85781e83a9b10bfbdd236ee812040730eb3a9b3f74e06aebc98fed6a6305ec35 · Zeichen 315–760 im Abschnitt
Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 14–15
HOS-112085 · Präparat HOS-093615
14
Medicinal products by Interaction Recommendations concerning co-
therapeutic area administration
ANTIMYCOBACTERIAL
Rifabutin 150 mg twice weekly Rifabutin AUC: ↑48% (↑19% ↑84%)** When given with REYATAZ, the
(atazanavir 300 mg and ritonavir Rifabutin Cmax: ↑149% (↑103% ↑206%)** recommended dose of rifabutin is
100 mg once daily) Rifabutin Cmin: ↑40% (↑5% ↑87%)** 150 mg 3 times per week on set
days (for example Monday-
25-O-desacetyl-rifabutin AUC: ↑990% Wednesday-Friday). Increased
(↑714% ↑1 361%)** monitoring for rifabutin-associated
25-O-desacetyl-rifabutin Cmax: ↑677% adverse reactions including
(↑513% ↑883%)** neutropenia and uveitis is warranted
25-O-desacetyl-rifabutin Cmin: ↑1 045% due to an expected increase in
(↑715% ↑1 510%)** exposure to rifabutin. Further
dosage reduction of rifabutin to
**When compared to rifabutin 150 mg 150 mg twice weekly on set days is
once daily alone. Total rifabutin and recommended for patients in whom
25-O-desacetyl-rifabutin AUC: ↑119% the 150 mg dose 3 times per week
(↑78% ↑169%). is not tolerated. It should be kept in
mind that the twice weekly dosage
In previous studies, the pharmacokinetics of 150 mg may not provide an
of atazanavir was not altered by rifabutin. optimal exposure to rifabutin thus
leading to a risk of rifamycin
resistance and a treatment failure.
No dose adjustment is needed for
REYATAZ.
Rifampicin Rifampicin is a strong CYP3A4 inducer The combination of rifampicin and
and has been shown to cause a 72% REYATAZ is contraindicated
decrease in atazanavir AUC which can (see section 4.3).
result in virological failure and resistance
development. During attempts to
overcome the decreased exposure by
increasing the dose of REYATAZ or other
protease inhibitors with ritonavir, a high
frequency of liver reactions was seen.
ANTIPSYCHOTICS
Quetiapine Due to CYP3A4 inhibition by REYATAZ, Co-administration of quetiapine
concentrations of quetiapine are expected with REYATAZ is contraindicated
to increase. as REYATAZ may increase
quetiapine-related toxicity.
Increased plasma concentrations of
quetiapine may lead to coma
(see section 4.3).
Lurasidone REYATAZ is expected to increase plasma Co-administration of lurasidone
levels of lurasidone due to CYP3A4 with REYATAZ is contraindicated
inhibition. as this may increase lurasidone-
related toxicity (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) protease (HOS-085623) rifabutin (HOS-086262) lead (HOS-085592) ritonavir (HOS-084521) lurasidone (HOS-086148)
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This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.