Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.
Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
Bedaquiline No interaction study is available with ritonavir only. In an interaction study of
single-dose bedaquiline and multiple dose lopinavir/ritonavir, the AUC of
bedaquiline was increased by 22%. This increase is likely due to ritonavir and a
more pronounced effect may be observed during prolonged co-administration. Due
to the risk of bedaquiline related adverse events, co-administration should be
avoided. If the benefit outweighs the risk, co-administration of bedaquiline with
ritonavir must be done with caution. More frequent electrocardiogram monitoring
and monitoring of transaminases is recommended (see section 4.4 and refer to the
bedaquiline SmPC).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
49
Ritonavir effects on Non-antiretroviral Co-administered Medicinal Products
Co-administered Medicinal Products Dose of Co-administered Medicinal Dose of Effect on Co- Effect on Co-
Products (mg) NORVIR administered administered
(mg) Medicinal Medicinal
Products Products Cmax
AUC
Bedaquiline No interaction study is available with ritonavir only. In an interaction study of single-dose
bedaquiline and multiple dose lopinavir/ritonavir, the AUC of bedaquiline was increased
by 22%. This increase is likely due to ritonavir and a more pronounced effect may be
observed during prolonged co-administration. Due to the risk of bedaquiline related
adverse events, co-administration should be avoided. If the benefit outweighs the risk,
co-administration of bedaquiline with ritonavir must be done with caution. More frequent
electrocardiogram monitoring and monitoring of transaminases is recommended (see
section 4.4 and refer to the bedaquiline SmPC).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 31738bbc16b4c93df384898192dda583972908126d2b2e301991a8d91064b893 · Zeichen 33608–35264 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.