Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Tasmar
Tasmar 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6
HOS-086561 · Präparat HOS-083306
Catechols and other drugs metabolised by catechol-O-methyltransferase (COMT)
Tolcapone may influence the pharmacokinetics of drugs metabolised by COMT. No effects were seen
on the pharmacokinetics of the COMT substrate carbidopa. An interaction was observed with
benserazide, which may lead to increased levels of benserazide and its active metabolite. The magnitude
of the effect was dependent on the dose of benserazide. The plasma concentrations of benserazide
observed after co-administration of tolcapone and benserazide-25 mg/levodopa were still within the
range of values observed with levodopa/benserazide alone. On the other hand, after coadministration of
tolcapone and benserazide-50 mg/levodopa the benserazide plasma concentrations could be increased
above the levels usually observed with levodopa/benserazide alone. The effect of tolcapone on the
pharmacokinetics of other drugs metabolised by COMT such as -methyldopa, dobutamine,
apomorphine, adrenaline and isoprenaline have not been evaluated. The prescriber should be observant
of adverse reactions caused by putative increased plasma levels of these drugs when combined with
Tasmar.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): carbidopa (HOS-086562) dobutamine (HOS-086565) apomorphine (HOS-086566) lead (HOS-085592) benserazide (HOS-086563) levodopa (HOS-086559) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-09-10T13:49:00Z · SHA-256 8ce859140f9a095e62d5fef3a3e25bd89320c57ae3e287a376abb5c14d6c4437 · Passage e79962e4782917307a0da569a9c64d5fe16790a76c30db979f6d915f33b0c1f7 · Zeichen 1003–2156 im Abschnitt
Wechselwirkungen · Tasmar
Tasmar 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 18
HOS-086592 · Präparat HOS-083306
Catechols and other drugs metabolised by catechol-O-methyltransferase (COMT)
Tolcapone may influence the pharmacokinetics of drugs metabolised by COMT. No effects were seen
on the pharmacokinetics of the COMT substrate carbidopa. An interaction was observed with
benserazide, which may lead to increased levels of benserazide and its active metabolite. The magnitude
of the effect was dependent on the dose of benserazide. The plasma concentrations of benserazide
observed after co-administration of tolcapone and benserazide-25 mg/levodopa were still within the
range of values observed with levodopa/benserazide alone. On the other hand, after coadministration of
tolcapone and benserazide-50 mg/levodopa the benserazide plasma concentrations could be increased
above the levels usually observed with levodopa/benserazide alone. The effect of tolcapone on the
pharmacokinetics of other drugs metabolised by COMT such as -methyldopa, dobutamine,
apomorphine, adrenaline and isoprenaline have not been evaluated. The prescriber should be observant
of adverse reactions caused by putative increased plasma levels of these drugs when combined with
Tasmar.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): carbidopa (HOS-086562) dobutamine (HOS-086565) apomorphine (HOS-086566) lead (HOS-085592) benserazide (HOS-086563) levodopa (HOS-086559) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-09-10T13:49:00Z · SHA-256 8ce859140f9a095e62d5fef3a3e25bd89320c57ae3e287a376abb5c14d6c4437 · Passage e79962e4782917307a0da569a9c64d5fe16790a76c30db979f6d915f33b0c1f7 · Zeichen 1003–2156 im Abschnitt
Wechselwirkungen · Comtess
Comtess 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4–5
HOS-087880 · Präparat HOS-083575
4
and selegiline were observed in repeated-dose studies in parkinsonian patients. However, the
experience of the clinical use of entacapone with several medicinal products, including MAO-A
inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine,
maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol-
structured compounds: rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine,
alpha-methyldopa, apomorphine, and paroxetine) is still limited. Caution should be exercised when
these medicinal products are used concomitantly with entacapone (see also sections 4.3 and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maprotiline (HOS-086572) paroxetine (HOS-086246) desipramine (HOS-086249) dopamine (HOS-085948) venlafaxine (HOS-086573) dobutamine (HOS-086565) apomorphine (HOS-086566) selegiline (HOS-086575) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-09-18T01:00:00Z · SHA-256 fa3d8879d7f9d8835c303451aba5afa0417c9a42bba423f3f71a40c3f8d94d33 · Passage 3c592197fa296402268e76a507959b26c502f61c3b5567c38fa7d68d94e5d6c3 · Zeichen 418–1090 im Abschnitt
Wechselwirkungen · Comtan
Comtan 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4–5
HOS-087903 · Präparat HOS-083583
4
imipramine or between entacapone and moclobemide. Similarly, no interactions between entacapone
and selegiline were observed in repeated-dose studies in parkinsonian patients. However, the
experience of the clinical use of entacapone with several medicinal products, including MAO-A
inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine,
maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol-
structured compounds: rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine,
alpha-methyldopa, apomorphine, and paroxetine) is still limited. Caution should be exercised when
these medicinal products are used concomitantly with entacapone (see also sections 4.3 and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maprotiline (HOS-086572) paroxetine (HOS-086246) desipramine (HOS-086249) dopamine (HOS-085948) imipramine (HOS-085907) moclobemide (HOS-087879) venlafaxine (HOS-086573) rimiterol (HOS-087904) dobutamine (HOS-086565) apomorphine (HOS-086566) selegiline (HOS-086575) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-05-07T16:36:00Z · SHA-256 5a934525674e083ec4dd9056db2e81d6f6bd7e081e45463e4be2195fdd4c2470 · Passage 607c7c228205279947c9a575e4730f7853ea1c18929afcfc4a48e376ed14e9a1 · Zeichen 322–1089 im Abschnitt
Wechselwirkungen · INOmax
INOmax 400 ppm mol/mol medicinal gas, compressed · Abschnitt 4.5 · PDF-Seite 6
HOS-108515 · Präparat HOS-093033
No interaction studies have been performed.
A clinically significant interaction with other medicinal products used in the treatment of hypoxic
respiratory failure cannot be excluded based on the available data. There may be an additive effect
with INOmax on the risk of developing methaemoglobinemia with nitric oxide donor substances,
including sodium nitroprusside and nitroglycerin. INOmax has been safely administered with
tolazoline, dopamine, dobutamine, steroids, surfactant, and high-frequency ventilation.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sodium nitroprusside (HOS-108516) dopamine (HOS-085948) dobutamine (HOS-086565) tolazoline (HOS-108518) nitroglycerin (HOS-108517)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-15T11:01:00Z · SHA-256 4c3ecbe485d3d0d3f3d8a8b72af806e039310534c247a674f80a0286630fc6f8 · Passage dab7a389668e50d053c9d3555bd8c0eab012fc25696c5b28f1962aef58f4ba2e · Zeichen 0–600 im Abschnitt
Wechselwirkungen · INOmax
INOmax 800 ppm mol/mol medicinal gas, compressed · Abschnitt 4.5 · PDF-Seite 18
HOS-108537 · Präparat HOS-093033
No interaction studies have been performed.
A clinically significant interaction with other medicinal products used in the treatment of hypoxic
respiratory failure cannot be excluded based on the available data. There may be an additive effect
with INOmax on the risk of developing methaemoglobinemia with nitric oxide donor substances,
including sodium nitroprusside and nitroglycerin. INOmax has been safely administered with
tolazoline, dopamine, dobutamine, steroids, surfactant, and high-frequency ventilation.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sodium nitroprusside (HOS-108516) dopamine (HOS-085948) dobutamine (HOS-086565) tolazoline (HOS-108518) nitroglycerin (HOS-108517)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-15T11:01:00Z · SHA-256 4c3ecbe485d3d0d3f3d8a8b72af806e039310534c247a674f80a0286630fc6f8 · Passage dab7a389668e50d053c9d3555bd8c0eab012fc25696c5b28f1962aef58f4ba2e · Zeichen 0–600 im Abschnitt
Wechselwirkungen · Entacapone Teva
Entacapone Teva 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4
HOS-213534 · Präparat HOS-155128
In single-dose studies in healthy volunteers, no interactions were observed between entacapone and
imipramine or between entacapone and moclobemide. Similarly, no interactions between entacapone
and selegiline were observed in repeated-dose studies in parkinsonian patients. However, the
experience of the clinical use of entacapone with several medicinal products, including MAO-A
inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline
and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol-structured
compounds: rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-
methyldopa, apomorphine, and paroxetine) is still limited. Caution should be exercised when these
medicinal products are used concomitantly with entacapone (see also sections 4.3 and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maprotiline (HOS-086572) paroxetine (HOS-086246) desipramine (HOS-086249) dopamine (HOS-085948) imipramine (HOS-085907) moclobemide (HOS-087879) venlafaxine (HOS-086573) dobutamine (HOS-086565) apomorphine (HOS-086566) selegiline (HOS-086575) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2021-09-28T17:49:00Z · SHA-256 a1bd223632cc773f7d6b9c4c6c3717b6bb040156eb55488dc0e81428b647ce20 · Passage d28934dc54dbd13dea735cd13a3c66783dab1bfafac92610aa00a62b311d4345 · Zeichen 171–1035 im Abschnitt
Wechselwirkungen · Entacapone Orion
Entacapone Orion 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4–5
HOS-215641 · Präparat HOS-155488
4
experience of the clinical use of entacapone with several medicinal products, including MAO-A
inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine,
maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e.g. catechol-
structured compounds: rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine,
alpha-methyldopa, apomorphine, and paroxetine) is still limited. Caution should be exercised when
these medicinal products are used concomitantly with entacapone (see also sections 4.3 and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maprotiline (HOS-086572) paroxetine (HOS-086246) desipramine (HOS-086249) dopamine (HOS-085948) venlafaxine (HOS-086573) dobutamine (HOS-086565) apomorphine (HOS-086566) methyldopa (HOS-086564)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-09-24T11:10:00Z · SHA-256 3eb4e83d0bea670f09b10f71bef77c228824c1e10efb8c36a0cf3aa5315b81fe · Passage dd1d6a1b67875866d02a2feca2ca369e0b23c9161352e02aadb463f889fe1ab8 · Zeichen 511–1090 im Abschnitt
Wechselwirkungen · Ongentys
Ongentys 25 mg hard capsules Ongentys 50 mg hard capsules · Abschnitt 4.5 · PDF-Seite 5
HOS-129702 · Präparat HOS-096787
Opicapone may interfere with the metabolism of medicinal products containing a catechol group that
are metabolised by COMT, e.g. rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine,
dopexamine or dobutamine, leading to potentiated effects of these medicinal products. Careful
monitoring of patients being treated with these medicinal products is advised when opicapone is used.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): dopexamine (HOS-129704) dopamine (HOS-085948) dobutamine (HOS-086565)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-07T10:00:00Z · SHA-256 5440c5fa9668dadbdfe2b487d148f72232f8fdbfa654e4a6492429ca5c3f530f · Passage 690ef5aa5d540bcaaeb60e24537dc514ba8a18bbda88cdad77558ca3cbe873a3 · Zeichen 920–1307 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.