Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 871 Präparate · 48256 Quellenpassagen · 124 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Viagra
VIAGRA 25 mg film-coated tablets VIAGRA 50 mg film-coated tablets VIAGRA 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6–7
HOS-088790 · Präparat HOS-083727
Although specific interaction studies were not conducted for all medicinal products, population
pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics
when grouped as CYP2C9 inhibitors (such as tolbutamide, warfarin, phenytoin), CYP2D6 inhibitors
(such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related
diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium
channel blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism (such as
rifampicin, barbiturates). In a study of healthy male volunteers, co-administration of the endothelin
antagonist, bosentan, (an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19) at
steady state (125 mg twice a day) with sildenafil at steady state (80 mg three times a day) resulted in
62.6% and 55.4% decrease in sildenafil AUC and Cmax, respectively. Therefore, concomitant
administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in
plasma concentrations of sildenafil.
6
Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has
the potential to result in a serious interaction with sildenafil.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nicorandil (HOS-088792) serotonin (HOS-085477) potassium (HOS-086929) calcium (HOS-085615) bosentan (HOS-086291) rifampin (HOS-088791) tolbutamide (HOS-086568) warfarin (HOS-085950) phenytoin (HOS-084531)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T10:49:00Z · SHA-256 6ad3c46b09a0a4a504f9373ab6370260a3b70fd305f7a7b80959175ca84b454e · Passage a415476c6ae9aeb0e206ed6048a80ed34232506c3786c35cbe7ea906c3e6b701 · Zeichen 2926–4255 im Abschnitt
Wechselwirkungen · Viagra
VIAGRA 50 mg orodispersible tablets · Abschnitt 4.5 · PDF-Seite 20
HOS-088849 · Präparat HOS-083727
Although specific interaction studies were not conducted for all medicinal products, population
pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics
when grouped as CYP2C9 inhibitors (such as tolbutamide, warfarin, phenytoin), CYP2D6 inhibitors
(such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related
diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium
channel blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism (such as
rifampicin, barbiturates). In a study of healthy male volunteers, co-administration of the endothelin
antagonist, bosentan, (an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19) at
steady state (125 mg twice a day) with sildenafil at steady state (80 mg three times a day) resulted in
62.6% and 55.4% decrease in sildenafil AUC and Cmax, respectively. Therefore, concomitant
administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in
plasma concentrations of sildenafil.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): serotonin (HOS-085477) potassium (HOS-086929) calcium (HOS-085615) bosentan (HOS-086291) rifampin (HOS-088791) tolbutamide (HOS-086568) warfarin (HOS-085950) phenytoin (HOS-084531)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T10:49:00Z · SHA-256 6ad3c46b09a0a4a504f9373ab6370260a3b70fd305f7a7b80959175ca84b454e · Passage ff031b81b0c99a94fcaa56bc3b110e0f54f206bf85a99290bc93652b329e3366 · Zeichen 2983–4088 im Abschnitt
Wechselwirkungen · Viagra
VIAGRA 50 mg orodispersible tablets · Abschnitt 4.5 · PDF-Seite 20
HOS-088850 · Präparat HOS-083727
Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has
the potential to result in a serious interaction with sildenafil.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nicorandil (HOS-088792) potassium (HOS-086929)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T10:49:00Z · SHA-256 6ad3c46b09a0a4a504f9373ab6370260a3b70fd305f7a7b80959175ca84b454e · Passage 347a8ec341b8ac5275fcb7b72dd32dcd7b1aaf723eedf21187c7b57f1e5044b8 · Zeichen 4090–4258 im Abschnitt
Wechselwirkungen · Viagra
VIAGRA 50 mg orodispersible films · Abschnitt 4.5 · PDF-Seite 34
HOS-088899 · Präparat HOS-083727
Although specific interaction studies were not conducted for all medicinal products, population
pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics
when grouped as CYP2C9 inhibitors (such as tolbutamide, warfarin, phenytoin), CYP2D6 inhibitors
(such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related
diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium
channel blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism (such as
rifampicin, barbiturates). In a study of healthy male volunteers, co-administration of the endothelin
antagonist, bosentan, (an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19) at
steady state (125 mg twice a day) with sildenafil at steady state (80 mg three times a day) resulted in
62.6% and 55.4% decrease in sildenafil AUC and Cmax, respectively. Therefore, concomitant
administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in
plasma concentrations of sildenafil.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bosentan (HOS-086291) rifampin (HOS-088791) serotonin (HOS-085477) potassium (HOS-086929) calcium (HOS-085615) tolbutamide (HOS-086568) warfarin (HOS-085950) phenytoin (HOS-084531)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T10:49:00Z · SHA-256 6ad3c46b09a0a4a504f9373ab6370260a3b70fd305f7a7b80959175ca84b454e · Passage ff031b81b0c99a94fcaa56bc3b110e0f54f206bf85a99290bc93652b329e3366 · Zeichen 2981–4086 im Abschnitt
Wechselwirkungen · Viagra
VIAGRA 50 mg orodispersible films · Abschnitt 4.5 · PDF-Seite 34
HOS-088900 · Präparat HOS-083727
Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has
the potential to result in a serious interaction with sildenafil.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nicorandil (HOS-088792) potassium (HOS-086929)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T10:49:00Z · SHA-256 6ad3c46b09a0a4a504f9373ab6370260a3b70fd305f7a7b80959175ca84b454e · Passage 347a8ec341b8ac5275fcb7b72dd32dcd7b1aaf723eedf21187c7b57f1e5044b8 · Zeichen 4088–4256 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.