Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Evista
Evista 60 mg film coated tablets · Abschnitt 4.5 · PDF-Seite 4
HOS-088379 · Präparat HOS-083635
In vitro, raloxifene did not interact with the binding of warfarin, phenytoin, or tamoxifen.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380) phenytoin (HOS-084531) warfarin (HOS-085950)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-04-01T12:30:00Z · SHA-256 f4ce424f62210f59bcb50c6293efacced149e50104e46c80a22544ef7153a17d · Passage 29566590f4c3d41b22eccd2788423a66c0568ac1adec5052494e32d7b9760eee · Zeichen 1529–1621 im Abschnitt
Wechselwirkungen · Targretin
Targretin 75 mg soft capsules · Abschnitt 4.5 · PDF-Seite 5
HOS-091527 · Präparat HOS-084349
Caution is advised in case of combination with CYP3A4 substrates having a narrow therapeutic
margin i.e. immunosuppressive agents (cyclosporine, tacrolimus, sirolimus) as well as
CYP3A4-metabolised cytotoxics, i.e. cyclophosphamide, etoposide, finasteride, ifosfamide,
tamoxifen, vinca-alcaloids.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): finasteride (HOS-091528) tamoxifen (HOS-088380) etoposide (HOS-086021) ifosfamide (HOS-091529) tacrolimus (HOS-085202) cyclophosphamide (HOS-084539) sirolimus (HOS-085172) cyclosporine (HOS-084512)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-08-12T12:14:00Z · SHA-256 3bf4d2f2fd7cbd6812f185953fbdb6223f58862715009080d9c1b2058c9f08b5 · Passage 998c3b3a660fadbd0afbd519254258d77ac0a27f6b9f61c16422b0e3d345032e · Zeichen 608–904 im Abschnitt
Wechselwirkungen · Targretin
Targretin 75 mg soft capsules · Abschnitt 4.5 · PDF-Seite 5
HOS-091531 · Präparat HOS-084349
Effects of bexarotene on other substances
There are indications that bexarotene may induce CYP3A4. Therefore, repeated administration of
bexarotene may result in an auto-induction of its own metabolism and, particularly at dose levels
greater than 300 mg/m2/day, may increase the rate of metabolism and reduce plasma concentrations of
other substances metabolised by cytochrome P450 3A4, such as tamoxifen. For example bexarotene
may reduce the efficacy of oral contraceptives (see sections 4.4 and 4.6).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2025-08-12T12:14:00Z · SHA-256 3bf4d2f2fd7cbd6812f185953fbdb6223f58862715009080d9c1b2058c9f08b5 · Passage f8c9009ec62bee01fad0014c068efd5f1d10e55a832f5414a8f77b939e238e7c · Zeichen 1376–1880 im Abschnitt
Wechselwirkungen · Advagraf
Advagraf 0.5 mg prolonged-release hard capsules Advagraf 1 mg prolonged-release hard capsules Advagraf 3 mg prolonged-release hard capsules Advagraf 5 mg prolonged-release hard capsules · Abschnitt 4.5 · PDF-Seite 11–12
HOS-116820 · Präparat HOS-094481
11
Drug/Substance Class or Drug interaction effect Recommendations concerning
Name co-administration
In vitro the following May increase tacrolimus whole Monitor tacrolimus whole
substances have been shown blood trough concentrations and blood trough concentrations
to be potential inhibitors of increase the risk of serious adverse and reduce tacrolimus dose if
tacrolimus metabolism: reactions (e.g., neurotoxicity, QT needed [see section 4.2].
bromocriptine, cortisone, prolongation) [see section 4.4]. Monitor renal function, ECG
dapsone, ergotamine, for QT prolongation, and other
gestodene, lidocaine, side effects closely.
mephenytoin, midazolam,
nilvadipine, norethisterone,
quinidine, tamoxifen
Strong CYP3A4 inducers: May decrease tacrolimus whole It is recommended that
rifampicin, phenytoin, blood trough concentrations and concomitant use should be
carbamazepine, apalutamide, increase the risk of rejection [see avoided. If unavoidable,
enzalutamide, mitotane, or section 4.4]. patients may require an
St. John’s wort (Hypericum Maximal effect on tacrolimus blood increase in tacrolimus dose.
perforatum) concentrations may be achieved 1-2 Changes in tacrolimus dose
weeks after co-administration. The should be individualized and
effect may remain 1-2 weeks after adjusted as needed based on
completion of the treatment. tacrolimus trough
concentrations, which should
be assessed at initiation,
monitored frequently
throughout (starting within the
first few days) and re-
evaluated on and after
completion of the CYP3A4
inducer. After use of the
CYP3A4 inducer has ended,
tacrolimus dose may need to
be adjusted gradually. Monitor
graft function closely.
Moderate CYP3A4 inducers: May decrease tacrolimus whole Monitor tacrolimus whole
metamizole, phenobarbital, blood trough concentrations and blood trough concentrations
isoniazid, rifabutin, increase the risk of rejection [see and increase tacrolimus dose if
efavirenz, etravirine, section 4.4]. needed [see section 4.2].
nevirapine; weak CYP3A4 Monitor graft function closely.
inducers: flucloxacillin
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cortisone (HOS-114161) phenobarbital (HOS-085617) lidocaine (HOS-108866) carbamazepine (HOS-085618) rifabutin (HOS-086262) apalutamide (HOS-086212) tamoxifen (HOS-088380) quinidine (HOS-085593) etravirine (HOS-088088) mephenytoin (HOS-109801) mitotane (HOS-112479) bromocriptine (HOS-090620) efavirenz (HOS-087947) nilvadipine (HOS-116826) gestodene (HOS-116824) nevirapine (HOS-088064) ergotamine (HOS-086154) isoniazid (HOS-088590) dapsone (HOS-088141) phenytoin (HOS-084531) enzalutamide (HOS-116829) midazolam (HOS-086167)
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Version 2025-02-27T10:10:00Z · SHA-256 0ed42bc08ffe6bd7e6c8ed94445bdb8b8c9971dabe41ef3a899ec75fc2f97c0e · Passage 9f68b7412442537a87ae5cc4a11a2083ae7ee1d4f84bacfd72b3336085546560 · Zeichen 8467–12012 im Abschnitt
Wechselwirkungen · Modigraf
Modigraf 0.2 mg granules for oral suspension Modigraf 1 mg granules for oral suspension · Abschnitt 4.5 · PDF-Seite 11–12
HOS-209751 · Präparat HOS-154375
11
Drug/Substance Class or Drug interaction effect Recommendations concerning co-
Name administration
The effect on tacrolimus
blood concentrations may
remain for several days after
co-administration is
completed.
Moderate or weak CYP3A4 May increase tacrolimus Monitor tacrolimus whole blood
inhibitors: whole blood trough trough concentrations frequently,
antifungal agents (e.g., concentrations and increase starting within the first few days
fluconazole, isavuconazole, the risk of serious adverse of co-administration. Reduce
clotrimazole, miconazole), reactions (e.g., neurotoxicity, tacrolimus dose if needed [see
the macrolide antibiotics QT prolongation) [see section 4.2]. Monitor renal
(e.g., azithromycin), calcium section 4.4]. A rapid increase function, ECG for QT
channel blockers (e.g., in tacrolimus level may prolongation, and other side
nifedipine, nicardipine, occur. effects closely.
diltiazem, verapamil),
amiodarone, danazol,
ethinylestradiol, lansoprazole,
omeprazole, the HCV
antivirals elbasvir/grazoprevir
and glecaprevir/pibrentasvir,
the CMV antiviral letermovir,
and the tyrosine kinase
inhibitors nilotinib, crizotinib
and imatinib and (Chinese)
herbal remedies containing
extracts of Schisandra
sphenanthera
In vitro the following May increase tacrolimus Monitor tacrolimus whole blood
substances have been shown whole blood trough trough concentrations and reduce
to be potential inhibitors of concentrations and increase tacrolimus dose if needed [see
tacrolimus metabolism: the risk of serious adverse section 4.2].
bromocriptine, cortisone, reactions (e.g., neurotoxicity, Monitor renal function, ECG for
dapsone, ergotamine, QT prolongation) [see QT prolongation, and other side
gestodene, lidocaine, section 4.4]. effects closely.
mephenytoin, midazolam,
nilvadipine, norethisterone,
quinidine, tamoxifen
Strong CYP3A4 inducers: May decrease tacrolimus It is recommended that
rifampicin, phenytoin whole blood trough concomitant use should be
carbamazepine, apalutamide, concentrations and increase avoided. If unavoidable, patients
enzalutamide, mitotane or St. the risk of rejection [see may require an increase in
John’s wort (Hypericum section 4.4]. tacrolimus dose. Changes in
perforatum) Maximal effect on tacrolimus tacrolimus dose should be
blood concentrations may be individualized and adjusted as
achieved 1-2 weeks after co- needed based on tacrolimus
administration. The effect trough concentrations, which
may remain 1-2 weeks after should be assessed at initiation,
completion of the treatment. monitored frequently throughout
(starting within the first few days)
and re-evaluated on and after
completion of the CYP3A4
inducer. After use of the CYP3A4
inducer has ended, tacrolimus
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lansoprazole (HOS-085166) letermovir (HOS-090621) diltiazem (HOS-086288) elbasvir (HOS-108814) isavuconazole (HOS-085186) nifedipine (HOS-086289) cortisone (HOS-114161) nicardipine (HOS-090619) pibrentasvir (HOS-086298) lidocaine (HOS-108866) carbamazepine (HOS-085618) crizotinib (HOS-116818) apalutamide (HOS-086212) tamoxifen (HOS-088380) quinidine (HOS-085593) glecaprevir (HOS-086297) azithromycin (HOS-088112) clotrimazole (HOS-090574) mephenytoin (HOS-109801) calcium (HOS-085615) imatinib (HOS-110212) grazoprevir (HOS-108815) danazol (HOS-085473) mitotane (HOS-112479) fluconazole (HOS-087945) bromocriptine (HOS-090620) nilvadipine (HOS-116826) gestodene (HOS-116824) ergotamine (HOS-086154) amiodarone (HOS-085596) tyrosine (HOS-108875) dapsone (HOS-088141) phenytoin (HOS-084531) enzalutamide (HOS-116829) nilotinib (HOS-086218) miconazole (HOS-115630) midazolam (HOS-086167) omeprazole (HOS-085912) verapamil (HOS-090602)
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Version 2025-03-03T17:00:00Z · SHA-256 1a464ac051c5783e49ce08a9d103d0d319997aa4add60584450928c1b11144a7 · Passage 1e7cc303a6d0d182851c23281c6a79a17f96d714a9cddc0ab3d6ada78ab947ab · Zeichen 6985–10993 im Abschnitt
Wechselwirkungen · Tepadina
TEPADINA 15 mg powder for concentrate for solution for infusion TEPADINA 100 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 7
HOS-210371 · Präparat HOS-154509
Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations
of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and
cyclophosphamide. CYP2B6 catalyzes the metabolic conversion of cyclophosphamide to its active
form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to
decreased concentrations of the active 4-OHCP. Therefore, a clinical monitoring should be exercised
during the concomitant use of thiotepa and these medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bupropion (HOS-086329) tamoxifen (HOS-088380) ifosfamide (HOS-091529) lead (HOS-085592) cyclophosphamide (HOS-084539) efavirenz (HOS-087947) 4-hydroxycyclophosphamide (HOS-210375)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 02fee406a06fed33cf20b2e58b8f5c3da3663e1afa93c280704add454e4e3420 · Zeichen 992–1544 im Abschnitt
Wechselwirkungen · Tepadina
TEPADINA 200 mg powder and solvent for solution for infusion TEPADINA 400 mg powder and solvent for solution for infusion · Abschnitt 4.5 · PDF-Seite 24
HOS-210415 · Präparat HOS-154509
Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations
of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and
cyclophosphamide. CYP2B6 catalyzes the metabolic conversion of cyclophosphamide to its active
form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to
decreased concentrations of the active 4-OHCP. Therefore, a clinical monitoring should be exercised
during the concomitant use of thiotepa and these medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bupropion (HOS-086329) tamoxifen (HOS-088380) ifosfamide (HOS-091529) lead (HOS-085592) cyclophosphamide (HOS-084539) efavirenz (HOS-087947) 4-hydroxycyclophosphamide (HOS-210375)
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Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 02fee406a06fed33cf20b2e58b8f5c3da3663e1afa93c280704add454e4e3420 · Zeichen 992–1544 im Abschnitt
Wechselwirkungen · Raloxifene Teva
Raloxifene Teva 60 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 4
HOS-210836 · Präparat HOS-154595
In vitro, raloxifene did not interact with the binding of warfarin, phenytoin, or tamoxifen.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380) phenytoin (HOS-084531) warfarin (HOS-085950)
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Version 2021-09-27T11:30:00Z · SHA-256 bbf6706a7418bb5343336909f5773d58520cc2fd4c0b1b303b9821080fd9b117 · Passage 29566590f4c3d41b22eccd2788423a66c0568ac1adec5052494e32d7b9760eee · Zeichen 1537–1629 im Abschnitt
Wechselwirkungen · Mysimba
Mysimba 8 mg/90 mg prolonged-release tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-130326 · Präparat HOS-096899
Drugs which require metabolic activation by CYP2D6 in order to be effective (e.g., tamoxifen), may
have reduced efficacy when administered concomitantly with inhibitors of CYP2D6 such as
bupropion. If naltrexone/bupropion is added to the treatment regimen of a patient already receiving a
drug metabolised by CYP2D6, the need to decrease the dose of the original medicinal product should
be considered, particularly for those concomitant medicinal products with a narrow therapeutic index.
When feasible, the option of therapeutic drug monitoring should be considered for medicinal
products with a narrow therapeutic index, such as tricyclic antidepressants.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2026-10-07T14:58:00Z · SHA-256 8d91203fd1313606105ccfcfeb588970833594eb1edb4edb571e8c8ed61c515c · Passage 974b58f6fb3caca0e265361304eed0d63304efbc4445d2ddc1a9e9305373b762 · Zeichen 2896–3554 im Abschnitt
Wechselwirkungen · Lynparza
Lynparza 100 mg film-coated tablets Lynparza 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10
HOS-130513 · Präparat HOS-096931
Combination with anastrozole, letrozole and tamoxifen
A clinical study has been performed to assess the combination of olaparib with anastrozole, letrozole
or tamoxifen. No clinically relevant interactions were observed.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): anastrozole (HOS-090912) tamoxifen (HOS-088380) letrozole (HOS-130515)
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Version 2026-02-19T16:20:00Z · SHA-256 04cb6a8e4fff66099a345e60858378068000de050b0e7fedaddb3d5347849598 · Passage 2fcf235b67e1486140c17a57c37e0fdc6b90923c73ef712216049f569b264c0a · Zeichen 4497–4717 im Abschnitt
Wechselwirkungen · Ibrance
IBRANCE 75 mg hard capsules IBRANCE 100 mg hard capsules IBRANCE 125 mg hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-132450 · Präparat HOS-097230
Effect of tamoxifen on palbociclib exposure
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2025-03-07T16:43:00Z · SHA-256 73a98bcaed2e5b347266ff9f037099270b545348fdf729a2479eedc3e06fd319 · Passage 87e9e08d728e071d02d6df9bca71cf2a659ae653b9a0a8ffc4ef2c0f12bb5889 · Zeichen 3626–3669 im Abschnitt
Wechselwirkungen · Ibrance
IBRANCE 75 mg hard capsules IBRANCE 100 mg hard capsules IBRANCE 125 mg hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-132451 · Präparat HOS-097230
Data from a DDI study in healthy male subjects indicated that palbociclib exposures were comparable
when a single dose of palbociclib was coadministered with multiple doses of tamoxifen and when
palbociclib was given alone.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2025-03-07T16:43:00Z · SHA-256 73a98bcaed2e5b347266ff9f037099270b545348fdf729a2479eedc3e06fd319 · Passage d9b951e7eb329fcb9391c21b01d193cd1b3bbc6c4d5a4cdc21b1d8f7b50c1bce · Zeichen 3671–3894 im Abschnitt
Wechselwirkungen · Ibrance
IBRANCE 75 mg film-coated tablets IBRANCE 100 mg film-coated tablets IBRANCE 125 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 32
HOS-132504 · Präparat HOS-097230
Effect of tamoxifen on palbociclib exposure
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2025-03-07T16:43:00Z · SHA-256 73a98bcaed2e5b347266ff9f037099270b545348fdf729a2479eedc3e06fd319 · Passage 87e9e08d728e071d02d6df9bca71cf2a659ae653b9a0a8ffc4ef2c0f12bb5889 · Zeichen 3240–3283 im Abschnitt
Wechselwirkungen · Ibrance
IBRANCE 75 mg film-coated tablets IBRANCE 100 mg film-coated tablets IBRANCE 125 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 32
HOS-132505 · Präparat HOS-097230
Data from a DDI study in healthy male subjects indicated that palbociclib exposures were comparable
when a single dose of palbociclib was coadministered with multiple doses of tamoxifen and when
palbociclib was given alone.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2025-03-07T16:43:00Z · SHA-256 73a98bcaed2e5b347266ff9f037099270b545348fdf729a2479eedc3e06fd319 · Passage d9b951e7eb329fcb9391c21b01d193cd1b3bbc6c4d5a4cdc21b1d8f7b50c1bce · Zeichen 3285–3508 im Abschnitt
Wechselwirkungen · Kisqali
Kisqali 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11
HOS-136246 · Präparat HOS-097860
Drug-drug interaction between ribociclib and tamoxifen
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2026-08-19T11:22:00Z · SHA-256 808e9743b462916472557a0fc0a032e5a4cdf4c2e48d8fd0f992823e92cc05c1 · Passage 6e976adf78d17c9f25c954d0910d496352f16e5cac7262eafc416e1df785369b · Zeichen 8214–8268 im Abschnitt
Wechselwirkungen · Kisqali
Kisqali 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11
HOS-136248 · Präparat HOS-097860
Data from a clinical study in patients with breast cancer indicated that tamoxifen exposure was
increased approximately 2-fold following co-administration of ribociclib and tamoxifen.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tamoxifen (HOS-088380)
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Version 2026-08-19T11:22:00Z · SHA-256 808e9743b462916472557a0fc0a032e5a4cdf4c2e48d8fd0f992823e92cc05c1 · Passage d87da26001349640e8e6a0f0196b119ddc28b76f2629c861da10bb53ef43bb37 · Zeichen 8270–8453 im Abschnitt
Wechselwirkungen · Kisqali
Kisqali 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12
HOS-136252 · Präparat HOS-097860
Anti-arrhythmic medicinal products and other medicinal products that may prolong the QT interval
Co-administration of Kisqali with medicinal products with a known potential to prolong the QT
interval such as anti-arrhythmic medicinal products (including, but not limited to, amiodarone,
disopyramide, procainamide, quinidine and sotalol), and other medicinal products that are known to
prolong the QT interval (including, but not limited to, chloroquine, halofantrine, clarithromycin,
ciprofloxacin, levofloxacin, azithromycin, haloperidol, methadone, moxifloxacin, bepridil, pimozide
and intravenous ondansetron) should be avoided (see section 4.4). Kisqali is also not recommended to
be used in combination with tamoxifen (see sections 4.1, 4.4 and 5.1).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sotalol (HOS-085597) methadone (HOS-086198) ciprofloxacin (HOS-085177) tamoxifen (HOS-088380) bepridil (HOS-085612) halofantrine (HOS-085606) quinidine (HOS-085593) azithromycin (HOS-088112) levofloxacin (HOS-128837) disopyramide (HOS-085595) procainamide (HOS-086617) clarithromycin (HOS-084517) pimozide (HOS-085600) moxifloxacin (HOS-085604) haloperidol (HOS-085602) amiodarone (HOS-085596) ondansetron (HOS-086052) chloroquine (HOS-109138)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-19T11:22:00Z · SHA-256 808e9743b462916472557a0fc0a032e5a4cdf4c2e48d8fd0f992823e92cc05c1 · Passage 58204aa4622d8004f93cd3949febb145336dedbece94dc5cc46a58898e28a2af · Zeichen 8724–9480 im Abschnitt
Wechselwirkungen · Verzenios
Verzenios 50 mg film-coated tablets Verzenios 100 mg film-coated tablets Verzenios 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-137584 · Präparat HOS-098067
In a clinical study in patients with breast cancer, there was no clinically-relevant pharmacokinetic drug
interaction between abemaciclib and anastrozole, fulvestrant, exemestane, letrozole or tamoxifen.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): anastrozole (HOS-090912) tamoxifen (HOS-088380) fulvestrant (HOS-112832) exemestane (HOS-137585) letrozole (HOS-130515)
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Version 2026-08-25T14:25:00Z · SHA-256 c20dfe266c62d9e17c31fc34e43834efb72c38097be1ba0a86293f7d6f279ed0 · Passage 6580526a3c74ba92e785597b461962921d2d9a7c3a995388542120de30d0a307 · Zeichen 2989–3192 im Abschnitt
Wechselwirkungen · Tacforius
Tacforius 0.5 mg prolonged-release hard capsules Tacforius 1 mg prolonged-release hard capsules Tacforius 3 mg prolonged-release hard capsules Tacforius 5 mg prolonged-release hard capsules · Abschnitt 4.5 · PDF-Seite 12–13
HOS-139170 · Präparat HOS-098290
12
Drug/Substance Class or Drug interaction effect Recommendations concerning
Name co-administration
In vitro the following May increase tacrolimus whole Monitor tacrolimus whole
substances have been shown blood trough concentrations and blood trough concentrations
to be potential inhibitors of increase the risk of serious adverse and reduce tacrolimus dose if
tacrolimus metabolism: reactions (e.g., neurotoxicity, QT needed (see section 4.2).
bromocriptine, cortisone, prolongation) (see section 4.4). Monitor renal function, ECG
dapsone, ergotamine, for QT prolongation, and other
gestodene, lidocaine, side effects closely.
mephenytoin, midazolam,
nilvadipine, norethisterone,
quinidine, tamoxifen.
Strong CYP3A4 inducers: May decrease tacrolimus whole It is recommended that
rifampicin, phenytoin, blood trough concentrations and concomitant use should be
carbamazepine, apalutamide, increase the risk of rejection (see avoided. If unavoidable,
enzalutamide, mitotane, or St. section 4.4). patients may require an
John’s wort (Hypericum Maximal effect on tacrolimus blood increase in tacrolimus dose.
perforatum) concentrations may be achieved 1-2 Changes in tacrolimus dose
weeks after co-administration. The should be individualized and
effect may remain 1-2 weeks after adjusted as needed based on
completion of the treatment. tacrolimus trough
concentrations, which should
be assessed at initiation,
monitored frequently
throughout (starting within the
first few days) and re-
evaluated on and after
completion of the CYP3A4
inducer. After use of the
CYP3A4 inducer has ended,
tacrolimus dose may need to
be adjusted gradually. Monitor
graft function closely.
Moderate CYP3A4 inducers: May decrease tacrolimus whole Monitor tacrolimus whole
metamizole, phenobarbital, blood trough concentrations and blood trough concentrations
isoniazid, rifabutin, efavirenz, increase the risk of rejection (see and increase tacrolimus dose if
etravirine, nevirapine section 4.4). needed (see section 4.2).
Weak CYP3A4 inducers: Monitor graft function closely.
flucloxacillin
Caspofungin May decrease tacrolimus whole Monitor tacrolimus whole
blood trough concentrations and blood trough concentrations
increase the risk of rejection. and increase tacrolimus dose if
Mechanism of interaction has not needed (see section 4.2).
been confirmed. Monitor graft function closely.
Cannabidiol (P-gp inhibitor) There have been reports of Tacrolimus and cannabidiol
increased tacrolimus blood levels should be co-administered with
during concomitant use of caution, closely monitoring for
tacrolimus with cannabidiol. This side effects. Monitor
may be due to inhibition of tacrolimus whole blood trough
intestinal P-glycoprotein, leading to concentrations and adjust the
increased bioavailability of tacrolimus dose if needed (see
tacrolimus. sections 4.2 and 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cortisone (HOS-114161) caspofungin (HOS-109306) phenobarbital (HOS-085617) lidocaine (HOS-108866) carbamazepine (HOS-085618) rifabutin (HOS-086262) apalutamide (HOS-086212) tamoxifen (HOS-088380) quinidine (HOS-085593) etravirine (HOS-088088) mephenytoin (HOS-109801) cannabidiol (HOS-090609) mitotane (HOS-112479) bromocriptine (HOS-090620) efavirenz (HOS-087947) nilvadipine (HOS-116826) gestodene (HOS-116824) nevirapine (HOS-088064) ergotamine (HOS-086154) isoniazid (HOS-088590) dapsone (HOS-088141) phenytoin (HOS-084531) enzalutamide (HOS-116829) midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-08T17:10:00Z · SHA-256 bf71e479a3104e9d8dd9aede574f2baf87c2d76cd8cc9266ee2ef92ed475dc55 · Passage fa1f35020c5c33f04f1dedfbde5310972baf1c60d65f0f37f47f320487c85aab · Zeichen 8700–13685 im Abschnitt
Wechselwirkungen · Voranigo
Voranigo 10 mg film-coated tablets Voranigo 40 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7
HOS-152390 · Präparat HOS-100749
Co-administration of vorasidenib with CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP3A4 substrates
with narrow therapeutic index (including, but not limited to, amitriptyline, alfentanil, carbamazepine,
ciclosporin, dosulepin, everolimus, fentanyl, fosphenytoin, ifosfamide, imipramine, phenobarbital,
phenytoin, pimozide, quinidine, sirolimus, tacrolimus, tamoxifen, trimipramine, valproic acid, and
warfarin) may decrease the plasma concentrations of these medicinal products. Concomitant use of
substrates of these enzymes with narrow therapeutic index should be avoided in patients taking
vorasidenib.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): fosphenytoin (HOS-110222) alfentanil (HOS-109375) amitriptyline (HOS-085911) phenobarbital (HOS-085617) valproic acid (HOS-088515) trimipramine (HOS-152398) carbamazepine (HOS-085618) imipramine (HOS-085907) tamoxifen (HOS-088380) quinidine (HOS-085593) ifosfamide (HOS-091529) tacrolimus (HOS-085202) pimozide (HOS-085600) everolimus (HOS-086310) sirolimus (HOS-085172) fentanyl (HOS-086196) phenytoin (HOS-084531) warfarin (HOS-085950)
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Version 2026-08-27T16:33:00Z · SHA-256 2232f34043666605447d216a0f9efae95496605e48741a446bf6879643808d62 · Passage 3d550b9ad3b19c779ebfbf7d68a0ec9fc3073bab44b0453f3efc8e4f9e0983a9 · Zeichen 1607–2205 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.