Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.
Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
- Co-administration with PDE5 inhibitors (such as sildenafil, tadalafil, vardenafil) (see
sections 4.2 and 4.5).
- Severe hepatic impairment (Child Pugh C).
- Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
- Pregnancy (see sections 4.4; 4.5 and 4.6).
- Co-administration with nitrates or nitric oxide donors (such as amyl nitrite) in any form
including recreational drugs called ‘poppers’ (see section 4.5).
- Concomitant use with other soluble guanylate cyclase stimulators.
- Treatment initiation for
o children aged 6 to < 12 years with systolic blood pressure < 90 mmHg,
o patients ≥ 12 to < 18 years with systolic blood pressure < 95 mmHg.
- Patients with pulmonary hypertension associated with idiopathic interstitial pneumonias (PH-
IIP) (see section 5.1).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Nitrates
In a clinical study the highest dose of riociguat (2.5 mg tablets 3 times daily) potentiated the blood
pressure lowering effect of sublingual nitroglycerin (0.4 mg) taken 4 and 8 hours after intake.
Therefore co-administration of riociguat with nitrates or nitric oxide donors (such as amyl nitrite) in
any form, including recreational drugs called ‘poppers’, is contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Nitrates
In a clinical study the highest dose of riociguat (2.5 mg tablets 3 times daily) potentiated the blood
pressure lowering effect of sublingual nitroglycerin (0.4 mg) taken 4 and 8 hours after intake.
Therefore co-administration of riociguat with nitrates or nitric oxide donors (such as amyl nitrite) in
any form, including recreational drugs called ‘poppers’, is contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Version 2026-05-22T01:00:00Z · SHA-256 3d1a5306a1e99b336747bac1f508fcb4f4b6128739940b8414bff8db32c20c38 · Passage 56d10bb505ac25f5710b503ce0ad8ac6b778aba6f400a674498c2baea7680a6d · Zeichen 309–715 im Abschnitt
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