Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Arava
Arava 10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-089672 · Präparat HOS-083907
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide
B1 and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide,
repaglinide, rifampicin) concomitant administration should also be undertaken with caution. Patients
should be closely monitored for signs and symptoms of excessive exposure to the medicinal
products and reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-07T09:36:00Z · SHA-256 cd6bb826d7f71e10dd6cea956a4c1d40ef339b9461b69d87c77735d5508df2d9 · Passage f37465d9d3fa779177b38c1116c6d5221ab029de8d593b9e1a786c9960c38e00 · Zeichen 5491–6465 im Abschnitt
Wechselwirkungen · Arava
Arava 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 26
HOS-089736 · Präparat HOS-083907
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide
B1 and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide,
repaglinide, rifampicin) concomitant administration should also be undertaken with caution. Patients
should be closely monitored for signs and symptoms of excessive exposure to the medicinal
products and reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-07T09:36:00Z · SHA-256 cd6bb826d7f71e10dd6cea956a4c1d40ef339b9461b69d87c77735d5508df2d9 · Passage f37465d9d3fa779177b38c1116c6d5221ab029de8d593b9e1a786c9960c38e00 · Zeichen 5493–6467 im Abschnitt
Wechselwirkungen · Arava
Arava 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 43
HOS-089796 · Präparat HOS-083907
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide
B1 and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide,
repaglinide, rifampicin) concomitant administration should also be undertaken with caution. Patients
should be closely monitored for signs and symptoms of excessive exposure to the medicinal
products and reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-07T09:36:00Z · SHA-256 cd6bb826d7f71e10dd6cea956a4c1d40ef339b9461b69d87c77735d5508df2d9 · Passage f37465d9d3fa779177b38c1116c6d5221ab029de8d593b9e1a786c9960c38e00 · Zeichen 5489–6463 im Abschnitt
Wechselwirkungen · Leflunomide Zentiva (previously Leflunomide Winthrop)
Leflunomide Zentiva 10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-122371 · Präparat HOS-095511
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide B1
and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide,
rifampicin) concomitant administration should also be undertaken with caution. Patients should be
closely monitored for signs and symptoms of excessive exposure to the medicinal products and
reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-22T17:27:00Z · SHA-256 bed6a472e84572491a61af1acb52b0f05e60157fe2f2f53c93e4e488c7c80e1b · Passage c722438444f15a50fbfd7f4174841441ed2887a9c672757af10708a7ffdb036d · Zeichen 5507–6481 im Abschnitt
Wechselwirkungen · Leflunomide Zentiva (previously Leflunomide Winthrop)
Leflunomide Zentiva 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 26
HOS-122435 · Präparat HOS-095511
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide B1
and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide,
rifampicin) concomitant administration should also be undertaken with caution. Patients should be
closely monitored for signs and symptoms of excessive exposure to the medicinal products and
reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-22T17:27:00Z · SHA-256 bed6a472e84572491a61af1acb52b0f05e60157fe2f2f53c93e4e488c7c80e1b · Passage c722438444f15a50fbfd7f4174841441ed2887a9c672757af10708a7ffdb036d · Zeichen 5507–6481 im Abschnitt
Wechselwirkungen · Leflunomide Zentiva (previously Leflunomide Winthrop)
Leflunomide Zentiva 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 43
HOS-122495 · Präparat HOS-095511
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide B1
and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide,
rifampicin) concomitant administration should also be undertaken with caution. Patients should be
closely monitored for signs and symptoms of excessive exposure to the medicinal products and
reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-22T17:27:00Z · SHA-256 bed6a472e84572491a61af1acb52b0f05e60157fe2f2f53c93e4e488c7c80e1b · Passage c722438444f15a50fbfd7f4174841441ed2887a9c672757af10708a7ffdb036d · Zeichen 5505–6479 im Abschnitt
Wechselwirkungen · Leflunomide medac
Leflunomide medac 10 mg film-coated tablets Leflunomide medac 15 mg film-coated tablets Leflunomide medac 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-213061 · Präparat HOS-155028
Effect on BCRP (Breast Cancer Resistance Protein) and/or organic anion transporting polypeptide B1
and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g. methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g. simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide,
rifampicin) concomitant administration should also be undertaken with caution. Patients should be
closely monitored for signs and symptoms of excessive exposure to the medicinal products and
reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-04T13:43:00Z · SHA-256 223d274d21039c4ccbd4617b929b92d6c05220acbdfe9a91a66492f4c4b82c33 · Passage 8643d6b670be172af69f37ce48416cfd76c57178d75d1a15610f0971df23e4a5 · Zeichen 5445–6416 im Abschnitt
Wechselwirkungen · Leflunomide ratiopharm
Leflunomide ratiopharm 10 mg film-coated tablets Leflunomide ratiopharm 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-213336 · Präparat HOS-155090
Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide B1
and B3 (OATP1B1/B3) substrates
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of A771726. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. If used together, the dose of
rosuvastatin should not exceed 10 mg once daily. For other substrates of BCRP (e.g., methotrexate,
topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially HMG-CoA
reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide, repaglinide,
rifampicin) concomitant administration should also be undertaken with caution. Patients should be
closely monitored for signs and symptoms of excessive exposure to the medicinal products and
reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-07-30T13:11:00Z · SHA-256 50316a891b82d00ee9a94d110a4117387e85a2bc5abc6b68dd9316418b3d816b · Passage c722438444f15a50fbfd7f4174841441ed2887a9c672757af10708a7ffdb036d · Zeichen 5512–6486 im Abschnitt
Wechselwirkungen · Aubagio
AUBAGIO 7 mg film-coated tablets AUBAGIO 14 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8–9
HOS-126673 · Präparat HOS-096301
8
There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively),
following repeated doses of teriflunomide. However, there was no apparent impact of this increase in
plasma rosuvastatin exposure on the HMG-CoA reductase activity. For rosuvastatin, a dose reduction
by 50% is recommended for coadministration with teriflunomide. For other substrates of BCRP (e.g.,
methotrexate, topotecan, sulfasalazine, daunorubicin, doxorubicin) and the OATP family especially
HMG-Co reductase inhibitors (e.g., simvastatin, atorvastatin, pravastatin, methotrexate, nateglinide,
repaglinide, rifampicin) concomitant administration of teriflunomide should also be undertaken with
caution. Patients should be closely monitored for signs and symptoms of excessive exposure to the
medicinal products and reduction of the dose of these medicinal products should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) sulfasalazine (HOS-089673) atorvastatin (HOS-086304) simvastatin (HOS-086158) rosuvastatin (HOS-086307) nateglinide (HOS-089675) topotecan (HOS-086047) doxorubicin (HOS-084538) repaglinide (HOS-086935) pravastatin (HOS-086306) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-12-09T14:35:00Z · SHA-256 590c2a61b8e2e029ec7654e3780b1cba8a07adbbaa44e9523484198edf4cb160 · Passage e8b04c0bca4e23a132a96ab39d8f8759c368eddb19db62da5b26d38e363cb56d · Zeichen 3928–4815 im Abschnitt
Wechselwirkungen · Cresemba
CRESEMBA 200 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 9–10
HOS-128908 · Präparat HOS-096645
(Mechanism unknown)
Other anticancer agents Not studied. No isavuconazole dose
(daunorubicin, doxorubicin, Daunorubicin, doxorubicin, adjustment necessary.
imatinib, irinotecan, lapatinib, imatinib, irinotecan, lapatinib, Daunorubicin, doxorubicin,
mitoxantrone, topotecan) mitoxantrone, topotecan imatinib, irinotecan, lapatinib,
(BCRP substrates) concentrations may increase. mitoxantrone or topotecan:
careful monitoring for any
(BCRP inhibition) occurrence of drug toxicity, and
dose reduction if required.
Antiemetics
Aprepitant Not studied. Co-administration should be
(mild CYP3A4/5 inducer) Isavuconazole concentrations may avoided unless the potential
decrease. benefit is considered to outweigh
the risk.
(CYP3A4/5 induction)
Antidiabetics
Metformin Metformin: No isavuconazole dose
(OCT1, OCT2 and MATE1 AUCinf: ↑ 52% adjustment necessary.
substrate) Cmax: ↑ 23% Metformin: dose reduction may
be required.
(OCT2 inhibition)
Repaglinide Repaglinide: No isavuconazole dose
(CYP2C8 and OATP1B1 AUCinf: ↓ 8% adjustment necessary.
substrate) Cmax: ↓ 14% Repaglinide: no dose adjustment
required.
Pioglitazone Not studied. Co-administration should be
(mild CYP3A4/5 inducer) avoided unless the potential
9
Isavuconazole concentrations may benefit is considered to outweigh
decrease. the risk.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) aprepitant (HOS-112506) imatinib (HOS-110212) lapatinib (HOS-122565) pioglitazone (HOS-089663) mitoxantrone (HOS-124775) topotecan (HOS-086047) doxorubicin (HOS-084538) irinotecan (HOS-112102) repaglinide (HOS-086935) metformin (HOS-091032)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-24T19:07:53Z · SHA-256 717f0eaf344e7731233baaa73335921f17bfdd86e9fa04c8f2a3921c343e8f3d · Passage 854a91e973c77b9e297df129810c589fef8306f228064f2fd1d019fbd0b296bc · Zeichen 11990–14467 im Abschnitt
Wechselwirkungen · Cresemba
CRESEMBA 40 mg hard capsules CRESEMBA 100 mg hard capsules · Abschnitt 4.5 · PDF-Seite 32
HOS-128988 · Präparat HOS-096645
(Mechanism unknown)
Other anticancer agents Not studied. No isavuconazole dose
(daunorubicin, doxorubicin, Daunorubicin, doxorubicin, adjustment necessary.
imatinib, irinotecan, lapatinib, imatinib, irinotecan, lapatinib, Daunorubicin, doxorubicin,
mitoxantrone, topotecan) mitoxantrone, topotecan imatinib, irinotecan, lapatinib,
(BCRP substrates) concentrations may increase. mitoxantrone or topotecan:
careful monitoring for any
(BCRP inhibition) occurrence of drug toxicity, and
dose reduction if required.
Antiemetics
Aprepitant Not studied. Co-administration should be
(mild CYP3A4/5 inducer) Isavuconazole concentrations may avoided unless the potential
decrease. benefit is considered to outweigh
the risk.
(CYP3A4/5 induction)
Antidiabetics
Metformin Metformin: No isavuconazole dose
(OCT1, OCT2 and MATE1 AUCinf: ↑ 52% adjustment necessary.
substrate) Cmax: ↑ 23% Metformin: dose reduction may
be required.
(OCT2 inhibition)
Repaglinide Repaglinide: No isavuconazole dose
(CYP2C8 and OATP1B1 AUCinf: ↓ 8% adjustment necessary.
substrate) Cmax: ↓ 14% Repaglinide: no dose adjustment
required.
Pioglitazone Not studied. Co-administration should be
(mild CYP3A4/5 inducer) Isavuconazole concentrations may avoided unless the potential
decrease. benefit is considered to outweigh
the risk.
(CYP3A4/5 induction)
Anticoagulants
Dabigatran etexilate Not studied. No isavuconazole dose
(P-gp substrate) Dabigatran etexilate concentrations adjustment necessary.
may increase. Dabigatran etexilate has a narrow
therapeutic index and should be
(P-gp inhibition). monitored, and dose reduction if
required.
Warfarin S-warfarin No isavuconazole dose
(CYP2C9 substrate) AUCinf: ↑ 11% adjustment necessary.
Cmax: ↓ 12% Warfarin: no dose adjustment
R-warfarin required.
AUCinf: ↑ 20%
Cmax: ↓ 7%
Antiretroviral agents
Lopinavir 400 mg / Ritonavir Lopinavir: No isavuconazole dose
100 mg AUCtau: ↓ 27% adjustment necessary; caution is
(CYP3A4/5 strong inhibitors Cmax: ↓ 23% advised as adverse drug reactions
and substrates) Cmin, ss: ↓ 16%a) may increase.
Ritonavir:
AUCtau: ↓ 31% Lopinavir/ritonavir: no dose
Cmax: ↓ 33% adjustment for lopinavir 400 mg /
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) lopinavir (HOS-086269) aprepitant (HOS-112506) imatinib (HOS-110212) lapatinib (HOS-122565) pioglitazone (HOS-089663) mitoxantrone (HOS-124775) ritonavir (HOS-084521) topotecan (HOS-086047) doxorubicin (HOS-084538) irinotecan (HOS-112102) dabigatran etexilate (HOS-086233) warfarin (HOS-085950) repaglinide (HOS-086935) metformin (HOS-091032)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-24T19:07:53Z · SHA-256 717f0eaf344e7731233baaa73335921f17bfdd86e9fa04c8f2a3921c343e8f3d · Passage 850ab84615b3abfe437182a0864ac0bf00ab067f02f0d89de60b13f59802225e · Zeichen 12228–16452 im Abschnitt
Wechselwirkungen · Oncaspar
Oncaspar 750 U/ml powder for solution for injection/infusion. · Abschnitt 4.5 · PDF-Seite 6
HOS-131516 · Präparat HOS-097087
The use of Oncaspar can lead to fluctuation in coagulation factors. This can promote the tendency to
bleeding and/or thrombosis. Caution is therefore needed when anticoagulants such as coumarin,
heparin, dipyridamole, acetylsalicylic acid or non-steroidal anti-inflammatory medicinal products are
given concomitantly, or when concomitant chemotherapy regimen including methotrexate,
daunorubicin, corticosteroids is administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): daunorubicin (HOS-089674) dipyridamole (HOS-088796) coumarin (HOS-088372) heparin (HOS-086930) lead (HOS-085592) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-05-07T15:25:00Z · SHA-256 76dc9eed7dc8fae840aac8646ddfd5b804f415269fe1e076c1b8ee3a8fd6ae06 · Passage 1770e95fa1dc4007cf792fa262225924ca75ed56efbd880bbcfd39dd948a306f · Zeichen 843–1272 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.