Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.
Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
10
acid has an effect on the pharmacodynamics of capecitabine and its toxicity may be enhanced by
folinic acid: the maximum tolerated dose (MTD) of capecitabine alone using the intermittent regimen
is 3000 mg/m2 per day whereas it is only 2000 mg/m2 per day when capecitabine was combined with
folinic acid (30 mg orally bid). The enhanced toxicity may be relevant when switching from 5- FU/LV
to a capecitabine regimen. This may also be relevant with folic acid supplementation for folate
deficiency due to the similarity between folinic acid and folic acid.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Folinic acid/folic acid
A combination study with capecitabine and folinic acid indicated that folinic acid has no major effect
on the pharmacokinetics of capecitabine and its metabolites. However, folinic acid has an effect on the
pharmacodynamics of capecitabine and its toxicity may be enhanced by folinic acid: the maximum
tolerated dose (MTD) of capecitabine alone using the intermittent regimen is 3000 mg/m2 per day
whereas it is only 2000 mg/m2 per day when capecitabine was combined with folinic acid (30 mg
orally bid). The enhanced toxicity may be relevant when switching from 5-FU/LV to a capecitabine
regimen. This may also be relevant with folic acid supplementation for folate deficiency due to the
similarity between folinic acid and folic acid.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Folinic acid/folic acid
A combination study with capecitabine and folinic acid indicated that folinic acid has no major effect
on the pharmacokinetics of capecitabine and its metabolites. However, folinic acid has an effect on the
pharmacodynamics of capecitabine and its toxicity may be enhanced by folinic acid: the maximum
tolerated dose (MTD) of capecitabine alone using the intermittent regimen is 3000 mg/m2 per day
whereas it is only 2000 mg/m2 per day when capecitabine was combined with folinic acid (30 mg
orally bid). The enhanced toxicity may be relevant when switching from 5-FU/LV to a capecitabine
regimen. This may also be relevant with folic acid supplementation for folate deficiency due to the
similarity between folinic acid and folic acid.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Version 2025-05-05T15:07:00Z · SHA-256 31136a37a67bcc7d3d37a3db0a926c5402c9346bcaefe911a69ae0fa32bf9225 · Passage 433d77d65cefbe27625c07f7ff658894188a441f7089970d82fb2923ac79ccdf · Zeichen 2427–3187 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.