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Wirkstoffe & Arzneimittelsicherheit

Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.

Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.

RxNorm 05-Oct-2026 · geprüft 2026-10-27 · 1381 Präparate · 72104 Quellenpassagen · 204 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.

Quellenpassagen (11)

Wechselwirkungen · Targretin

Targretin 75 mg soft capsules · Abschnitt 4.5 · PDF-Seite 5

HOS-091527 · Präparat HOS-084349

Caution is advised in case of combination with CYP3A4 substrates having a narrow therapeutic margin i.e. immunosuppressive agents (cyclosporine, tacrolimus, sirolimus) as well as CYP3A4-metabolised cytotoxics, i.e. cyclophosphamide, etoposide, finasteride, ifosfamide, tamoxifen, vinca-alcaloids.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): finasteride (HOS-091528) tamoxifen (HOS-088380) etoposide (HOS-086021) ifosfamide (HOS-091529) tacrolimus (HOS-085202) cyclophosphamide (HOS-084539) sirolimus (HOS-085172) cyclosporine (HOS-084512)

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Version 2025-08-12T12:14:00Z · SHA-256 3bf4d2f2fd7cbd6812f185953fbdb6223f58862715009080d9c1b2058c9f08b5 · Passage 998c3b3a660fadbd0afbd519254258d77ac0a27f6b9f61c16422b0e3d345032e · Zeichen 608–904 im Abschnitt

Wechselwirkungen · Emend

EMEND 125 mg hard capsules EMEND 80 mg hard capsules · Abschnitt 4.5 · PDF-Seite 5

HOS-112516 · Präparat HOS-093697

Chemotherapeutic medicinal products In pharmacokinetic studies, EMEND, when given as a regimen of 125 mg on Day 1 and 80 mg/day on Days 2 and 3, did not influence the pharmacokinetics of docetaxel administered intravenously on Day 1 or vinorelbine administered intravenously on Day 1 or Day 8. Because the effect of EMEND on the pharmacokinetics of orally administered CYP3A4 substrates is greater than the effect of EMEND on the pharmacokinetics of intravenously administered CYP3A4 substrates, an interaction with orally administered chemotherapeutic medicinal products metabolised primarily or partly by CYP3A4 (e.g., etoposide, vinorelbine) cannot be excluded. Caution is advised and additional monitoring may be appropriate in patients receiving medicinal products metabolised primarily or partly by CYP3A4 (see section 4.4). Postmarketing events of neurotoxicity, a potential adverse reaction of ifosfamide, have been reported after aprepitant and ifosfamide co-administration.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): etoposide (HOS-086021) ifosfamide (HOS-091529) docetaxel (HOS-084505) vinorelbine (HOS-112517)

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Version 2025-10-24T11:24:00Z · SHA-256 afd6062a51e59b36e448c9117685894e4529fcde2f5e673f4401f91bb32d7081 · Passage 89645b6df870cf474bf37feb3044c4bc8659d138a2e7182c037f0defac062724 · Zeichen 3111–4094 im Abschnitt

Wechselwirkungen · Emend

EMEND 125 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 22–23

HOS-112577 · Präparat HOS-093697

22 Day 1 or vinorelbine administered intravenously on Day 1 or Day 8. Because the effect of EMEND on the pharmacokinetics of orally administered CYP3A4 substrates is greater than the effect of EMEND on the pharmacokinetics of intravenously administered CYP3A4 substrates, an interaction with orally administered chemotherapeutic medicinal products metabolised primarily or partly by CYP3A4 (e.g., etoposide, vinorelbine) cannot be excluded. Caution is advised and additional monitoring may be appropriate in patients receiving medicinal products metabolised primarily or partly by CYP3A4 (see section 4.4). Postmarketing events of neurotoxicity, a potential adverse reaction of ifosfamide, have been reported after aprepitant and ifosfamide co-administration.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): etoposide (HOS-086021) ifosfamide (HOS-091529) vinorelbine (HOS-112517)

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Version 2025-10-24T11:24:00Z · SHA-256 afd6062a51e59b36e448c9117685894e4529fcde2f5e673f4401f91bb32d7081 · Passage b237ddaa2c1c30ed88c48f806a99352ff4837e83b928a8742dad3cec164759ca · Zeichen 3334–4094 im Abschnitt

Wechselwirkungen · Ivemend

IVEMEND 150 mg powder for solution for infusion. · Abschnitt 4.5 · PDF-Seite 7

HOS-117438 · Präparat HOS-094609

Chemotherapeutic medicinal products Interaction studies with fosaprepitant 150 mg and chemotherapeutic medicinal products have not been conducted; however, based on studies with oral aprepitant and docetaxel and vinorelbine, IVEMEND 150 mg is not expected to have a clinically relevant interaction with intravenously administered docetaxel and vinorelbine. An interaction with orally administered chemotherapeutic medicinal products metabolised primarily or partly by CYP3A4 (e.g., etoposide, vinorelbine) cannot be excluded. Caution is advised and additional monitoring may be appropriate in patients receiving medicinal products metabolised primarily or partly by CYP3A4 (see section 4.4). Postmarketing events of neurotoxicity, a potential adverse reaction of ifosfamide, have been reported after aprepitant and ifosfamide co-administration.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): aprepitant (HOS-112506) etoposide (HOS-086021) ifosfamide (HOS-091529) docetaxel (HOS-084505) vinorelbine (HOS-112517)

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Version 2025-11-05T14:57:00Z · SHA-256 9e19bc1fa93d788029c9702424aacb9622fe408d4db1dbe0bc9e0ad1d449f179 · Passage b78fc24de0358af2b4584638fa3e208590245fef03e4d180698051baf33c81fe · Zeichen 2891–3735 im Abschnitt

Wechselwirkungen · Tepadina

TEPADINA 15 mg powder for concentrate for solution for infusion TEPADINA 100 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 7

HOS-210371 · Präparat HOS-154509

Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and cyclophosphamide. CYP2B6 catalyzes the metabolic conversion of cyclophosphamide to its active form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to decreased concentrations of the active 4-OHCP. Therefore, a clinical monitoring should be exercised during the concomitant use of thiotepa and these medicinal products.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bupropion (HOS-086329) tamoxifen (HOS-088380) ifosfamide (HOS-091529) lead (HOS-085592) cyclophosphamide (HOS-084539) efavirenz (HOS-087947) 4-hydroxycyclophosphamide (HOS-210375)

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Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 02fee406a06fed33cf20b2e58b8f5c3da3663e1afa93c280704add454e4e3420 · Zeichen 992–1544 im Abschnitt

Wechselwirkungen · Tepadina

TEPADINA 200 mg powder and solvent for solution for infusion TEPADINA 400 mg powder and solvent for solution for infusion · Abschnitt 4.5 · PDF-Seite 24

HOS-210415 · Präparat HOS-154509

Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and cyclophosphamide. CYP2B6 catalyzes the metabolic conversion of cyclophosphamide to its active form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to decreased concentrations of the active 4-OHCP. Therefore, a clinical monitoring should be exercised during the concomitant use of thiotepa and these medicinal products.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bupropion (HOS-086329) tamoxifen (HOS-088380) ifosfamide (HOS-091529) lead (HOS-085592) cyclophosphamide (HOS-084539) efavirenz (HOS-087947) 4-hydroxycyclophosphamide (HOS-210375)

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Version 2026-02-24T14:00:00Z · SHA-256 42c8bab87a55159cb982d55f577a064273549ce149f75b75dbf4d5650be413bc · Passage 02fee406a06fed33cf20b2e58b8f5c3da3663e1afa93c280704add454e4e3420 · Zeichen 992–1544 im Abschnitt

Wechselwirkungen · Mysimba

Mysimba 8 mg/90 mg prolonged-release tablets · Abschnitt 4.5 · PDF-Seite 9

HOS-130330 · Präparat HOS-096899

Co-administration of medicinal products that may inhibit the metabolism of bupropion via CYP2B6 isoenzyme (e.g., CYP2B6 substrates: cyclophosphamide, ifosfamide, and CYP2B6 inhibitors: orphenadrine, ticlopidine, clopidogrel), may result in increased bupropion plasma levels and lower levels of active metabolite hydroxybupropion. The clinical consequences of the inhibition of the metabolism of bupropion via CYP2B6 enzyme and the consequent changes in the bupropion-hydroxybupropion ratio are currently unknown, but could potentially lead to reduced efficacy of naltrexone/bupropion.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): orphenadrine (HOS-130332) ifosfamide (HOS-091529) lead (HOS-085592) clopidogrel (HOS-087927) cyclophosphamide (HOS-084539) ticlopidine (HOS-087946)

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Version 2026-10-07T14:58:00Z · SHA-256 8d91203fd1313606105ccfcfeb588970833594eb1edb4edb571e8c8ed61c515c · Passage 2e9e72b24e46b32553a8091ca74aa11bb242b3cc556f555e7645ff504abc352c · Zeichen 4505–5089 im Abschnitt

Wechselwirkungen · Amglidia

AMGLIDIA 0.6 mg/mL oral suspension AMGLIDIA 6 mg/mL oral suspension · Abschnitt 4.5 · PDF-Seite 8–10

HOS-226728 · Präparat HOS-217644

Anabolic steroids and male Potentiation of the Hypoglycaemia sex hormones blood-glucose lowering effect Barbiturates Weakening of the Increased blood-glucose blood-glucose lowering levels effect Beta-receptor blockers Potentiation of the Hypoglycaemia blood-glucose lowering effect Signs of adrenergic Incorrect control of plasma counter-regulation to glucose hypoglycaemia may be reduced or absent Biguanides Potentiation of the Hypoglycaemia blood-glucose lowering effect Bosentan Increase liver enzymes Incorrect control of plasma glucose Calcium channel blockers Weakening of the blood- Increased blood-glucose glucose-lowering effect levels Chloramphenicol Potentiation of the Hypoglycaemia blood-glucose lowering effect Cimetidine Weakening of the blood- Increased blood-glucose glucose lowering effect levels Clarithromycin Potentiation of the blood- Hypoglycaemia glucose lowering effect Clonidine Potentiation of the blood- Hypoglycaemia glucose lowering effect Potentiation or weakening of Incorrect control of plasma the blood-glucose lowering glucose effect Signs of adrenergic counter- Incorrect control of plasma regulation to hypoglycaemia glucose may be reduced or absent Weakening of the blood- Increased blood-glucose glucose lowering effect levels Colesevelam Reduction of glibenclamide Incorrect control of plasma absorption from the glucose gastrointestinal tract Corticosteroids Weakening of the blood- Increased blood-glucose glucose lowering effect levels Coumarin derivatives Potentiation of the blood- Hypoglycaemia glucose lowering effect Potentiate or weaken the Incorrect dose of coumarin effect of coumarin derivatives administered derivatives Cyclophosphamides Potentiation of the blood- Hypoglycaemia glucose lowering effect Diazoxide Weakening of the blood- Increased blood-glucose glucose lowering effect levels Disopyramide Potentiation of the blood- Hypoglycaemia glucose lowering effect Diuretics Weakening of the blood- Increased blood-glucose glucose lowering effect levels Fenfluramine Potentiation of the blood- Hypoglycaemia glucose lowering effect Fenyramidol Potentiation of the blood- Hypoglycaemia glucose lowering effect Fibrates Potentiation of the blood- Hypoglycaemia glucose lowering effect Fluoxetine Potentiation of the blood- Hypoglycaemia glucose lowering effect Glucagon Weakening of the blood- Increased blood-glucose glucose lowering effect levels Guanethidine Potentiation of the blood- Hypoglycaemia glucose lowering effect Signs of adrenergic counter- Incorrect control of plasma regulation to hypoglycaemia glucose may be reduced or absent H2-receptor antagonists Potentiation or weakening of Incorrect control of plasma the blood-glucose lowering glucose effect Heparin Potentiation of the blood- Hypoglycaemia glucose lowering effect Ifosfamide Potentiation of the blood- Hypoglycaemia glucose lowering effect Insulin Potentiation of the blood- Hypoglycaemia glucose lowering effect Isoniazid Weakening of the blood- Increased blood-glucose glucoselowering effect levels Large doses of laxatives Weakening of the blood- Increased blood-glucose glucose lowering effect levels Long-acting Potentiation of the blood- Hypoglycaemia sulphonamides glucose lowering effect MAO inhibitors Potentiation of the blood- Hypoglycaemia glucose lowering effect Miconazole Potentiation of the blood- Hypoglycaemia glucose lowering effect Nicotinic acid (in high Weakening of the blood- Increased blood-glucose doses) glucose lowering effect levels Oestrogens Weakening of the blood- Increased blood-glucose glucose lowering effect levels Other oral antidiabetics Potentiation of the blood- Hypoglycaemia glucose lowering effect Oxypentifylline Potentiation of the blood- Hypoglycaemia glucose lowering effect Oxyphenbutazone Potentiation of the blood- Hypoglycaemia glucose lowering effect Phenothiazine derivatives Weakening of the blood- Increased blood-glucose glucose lowering effect levels Phenytoin Weakening of the blood- Increased blood-glucose glucose lowering effect levels Phosphamides Potentiation of the blood- Hypoglycaemia glucose lowering effect Probenecid Potentiation of the blood- Hypoglycaemia glucose lowering effect Progestogens Weakening of the blood- Increased blood-glucose glucose lowering effect levels Quinolone antibiotics Potentiation of the blood- Hypoglycaemia glucose lowering effect Reserpine Potentiation of the blood- Hypoglycaemia glucose lowering effect Potentiation or weakening of Incorrect control of plasma the blood-glucose lowering glucose effect Signs of adrenergic counter- Incorrect control of plasma regulation to hypoglycaemia glucose may be reduced or absent Rifampicin Weakening of the blood- Increased blood-glucose glucose lowering effect levels Thyroid hormones Weakening of the blood- Increased blood-glucose glucose lowering effect levels Salicylates Potentiation of the blood- Hypoglycaemia glucose lowering effect Sulfamethoxazole with Potentiation of the blood- Hypoglycaemia trimethoprim (Co- glucose lowering effect trimoxazole) Tetracycline compounds Potentiation of the blood- Hypoglycaemia glucose lowering effect Tritoqualine Potentiation of the blood- Hypoglycaemia glucose lowering effect

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sulfamethoxazole (HOS-084533) trimethoprim (HOS-085184) fenfluramine (HOS-115627) tetracycline (HOS-115153) cimetidine (HOS-085835) clonidine (HOS-088594) diazoxide (HOS-088588) glucose (HOS-088412) coumarin (HOS-088372) heparin (HOS-086930) ifosfamide (HOS-091529) calcium (HOS-085615) disopyramide (HOS-085595) clarithromycin (HOS-084517) probenecid (HOS-085208) tritoqualine (HOS-115631) fluoxetine (HOS-085946) chloramphenicol (HOS-115623) guanethidine (HOS-088596) bosentan (HOS-086291) colesevelam (HOS-112356) isoniazid (HOS-088590) reserpine (HOS-088597) phenytoin (HOS-084531) glucagon (HOS-088589) miconazole (HOS-115630) oxyphenbutazone (HOS-226734)

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Version 2023-12-06T13:39:00Z · SHA-256 9b31c8fd2e2c11b31d3834841c43620453c6c194a0c4f4a1689401e4cae4ff04 · Passage 65768f222638b6ec5b55799dedba422cfd4ab929c394f7deccb2b45b8e583e53 · Zeichen 3453–12347 im Abschnitt

Wechselwirkungen · Pemazyre

Pemazyre 4.5 mg tablets Pemazyre 9 mg tablets Pemazyre 13.5 mg tablets · Abschnitt 4.5 · PDF-Seite 7

HOS-145609 · Präparat HOS-099381

Effect of pemigatinib on CYP2B6 substrates In vitro studies indicate that pemigatinib induces CYP2B6. Co-administration of pemigatinib with CYP2B6 substrates (e.g. cyclophosphamide, ifosfamide, methadone, efavirenz) may decrease their exposure. Close clinical surveillance is recommended when pemigatinib is administered with these medicinal products or any CYP2B6 substrate having a narrow therapeutic index.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): methadone (HOS-086198) ifosfamide (HOS-091529) cyclophosphamide (HOS-084539) efavirenz (HOS-087947)

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Version 2026-03-17T16:40:00Z · SHA-256 8e535a113ae402c5cf3666356fff94af919f2d5254b892ef44d65c6c6506d36b · Passage 8ad37e56ee4bec0e2d0f6ae20131782a01348306de26cb1a6a983a1503796dc4 · Zeichen 1855–2264 im Abschnitt

Wechselwirkungen · Thiotepa Riemser

Thiotepa Riemser 15 mg powder for concentrate for solution for infusion Thiotepa Riemser 100 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 7

HOS-294844 · Präparat HOS-288098

Thiotepa is a weak inhibitor for CYP2B6, and may thereby potentially increase plasma concentrations of substances metabolised via CYP2B6, such as ifosfamide, tamoxifen, bupropion, efavirenz and cyclophosphamide. CYP2B6 catalyses the metabolic conversion of cyclophosphamide to its active form 4-hydroxycyclophosphamide (4-OHCP) and co-administration of thiotepa may therefore lead to decreased concentrations of the active 4-OHCP. Therefore, a clinical monitoring should be exercised during the concomitant use of thiotepa and these medicinal products.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): bupropion (HOS-086329) tamoxifen (HOS-088380) ifosfamide (HOS-091529) lead (HOS-085592) cyclophosphamide (HOS-084539) efavirenz (HOS-087947) 4-hydroxycyclophosphamide (HOS-210375)

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Version 2026-10-07T13:43:00Z · SHA-256 80e2cd7daef8e1a97ffe5b9cf2bb130175af781c7421d5c5278d3b796091bf37 · Passage b77a97370501e485dfa7bd2e5a4e75a3576b5f42a59c92eb02cc46f9daba244f · Zeichen 992–1544 im Abschnitt

Wechselwirkungen · Voranigo

Voranigo 10 mg film-coated tablets Voranigo 40 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7

HOS-152390 · Präparat HOS-100749

Co-administration of vorasidenib with CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP3A4 substrates with narrow therapeutic index (including, but not limited to, amitriptyline, alfentanil, carbamazepine, ciclosporin, dosulepin, everolimus, fentanyl, fosphenytoin, ifosfamide, imipramine, phenobarbital, phenytoin, pimozide, quinidine, sirolimus, tacrolimus, tamoxifen, trimipramine, valproic acid, and warfarin) may decrease the plasma concentrations of these medicinal products. Concomitant use of substrates of these enzymes with narrow therapeutic index should be avoided in patients taking vorasidenib.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): fosphenytoin (HOS-110222) alfentanil (HOS-109375) amitriptyline (HOS-085911) phenobarbital (HOS-085617) valproic acid (HOS-088515) trimipramine (HOS-152398) carbamazepine (HOS-085618) imipramine (HOS-085907) tamoxifen (HOS-088380) quinidine (HOS-085593) ifosfamide (HOS-091529) tacrolimus (HOS-085202) pimozide (HOS-085600) everolimus (HOS-086310) sirolimus (HOS-085172) fentanyl (HOS-086196) phenytoin (HOS-084531) warfarin (HOS-085950)

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Version 2026-08-27T16:33:00Z · SHA-256 2232f34043666605447d216a0f9efae95496605e48741a446bf6879643808d62 · Passage 3d550b9ad3b19c779ebfbf7d68a0ec9fc3073bab44b0453f3efc8e4f9e0983a9 · Zeichen 1607–2205 im Abschnitt

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.