Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Dynastat
Dynastat 40 mg powder for solution for injection · Abschnitt 4.5 · PDF-Seite 8
HOS-109373 · Präparat HOS-093187
Injectable anaesthetics
Coadministration of IV parecoxib 40 mg with propofol (CYP2C9 substrate) or midazolam (CYP3A4
substrate) did not affect either the pharmacokinetics (metabolism and exposure) or the
pharmacodynamics (EEG effects, psychomotor tests and waking from sedation) of IV propofol or IV
midazolam. Additionally, coadministration of valdecoxib had no clinically significant effect on the
hepatic or intestinal CYP 3A4-mediated metabolism of orally administered midazolam.
Administration of IV parecoxib 40 mg had no significant effect on the pharmacokinetics of either IV
fentanyl or IV alfentanil (CYP3A4 substrates).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) propofol (HOS-109374) fentanyl (HOS-086196) valdecoxib (HOS-109357) midazolam (HOS-086167)
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Version 2025-03-05T17:26:00Z · SHA-256 a94a02bdad229376a395299eccbc2ab09dd742598fb29796b8e5ada490a65e06 · Passage 662dd1373bd10ba5897ec0ebeead4763dae039c69209cdced5cce7496495d984 · Zeichen 5889–6519 im Abschnitt
Wechselwirkungen · Dynastat
Dynastat 40 mg powder and solvent for solution for injection · Abschnitt 4.5 · PDF-Seite 24
HOS-109414 · Präparat HOS-093187
Injectable anaesthetics
Coadministration of IV parecoxib 40 mg with propofol (CYP2C9 substrate) or midazolam (CYP3A4
substrate) did not affect either the pharmacokinetics (metabolism and exposure) or the
pharmacodynamics (EEG effects, psychomotor tests and waking from sedation) of IV propofol or IV
midazolam. Additionally, coadministration of valdecoxib had no clinically significant effect on the
hepatic or intestinal CYP 3A4-mediated metabolism of orally administered midazolam.
Administration of IV parecoxib 40 mg had no significant effect on the pharmacokinetics of either IV
fentanyl or IV alfentanil (CYP3A4 substrates).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) propofol (HOS-109374) fentanyl (HOS-086196) valdecoxib (HOS-109357) midazolam (HOS-086167)
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Version 2025-03-05T17:26:00Z · SHA-256 a94a02bdad229376a395299eccbc2ab09dd742598fb29796b8e5ada490a65e06 · Passage 662dd1373bd10ba5897ec0ebeead4763dae039c69209cdced5cce7496495d984 · Zeichen 5891–6521 im Abschnitt
Wechselwirkungen · Vfend
VFEND 50 mg film-coated tablets VFEND 200 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 16–17
HOS-109484 · Präparat HOS-093201
16
Non-steroidal selective mineralocorticoid receptor (MR) antagonists
Finerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
finerenone.
Eplerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
eplerenone.
Non-steroidal anti-inflammatory drugs (NSAIDs)
[CYP2C9 substrates] Frequent monitoring for adverse
S-Ibuprofen Cmax 20% reactions and toxicity related to
Ibuprofen (400 mg single dose) S-Ibuprofen AUC0- 100% NSAIDs is recommended. Dose
reduction of NSAIDs may be
Diclofenac (50 mg single dose) Diclofenac Cmax 114% needed.
Diclofenac AUC0- 78%
Opioids
Long-Acting Opiates In an independent published study, Dose reduction in oxycodone and
[CYP3A4 substrates] Oxycodone Cmax 1.7-fold other long-acting opiates
Oxycodone AUC0- 3.6-fold metabolised by CYP3A4
Oxycodone (10 mg single (e.g., hydrocodone) should be
dose) considered. Frequent monitoring
for opiate-associated adverse
reactions may be necessary.
Methadone (32-100 mg QD) R-methadone (active) Cmax 31% Frequent monitoring for adverse
[CYP3A4 substrate] R-methadone (active) AUC 47% reactions and toxicity related to
S-methadone Cmax 65% methadone, including QTc
S-methadone AUC 103% prolongation, is recommended.
Dose reduction of methadone
may be needed.
Short-acting Opiates Dose reduction of alfentanil,
[CYP3A4 substrates] fentanyl and other short-acting
opiates similar in structure to
Alfentanil (20 μg/kg single In an independent published study, alfentanil and metabolised by
dose, with concomitant Alfentanil AUC0- 6-fold CYP3A4 (e.g., sufentanil) should
naloxone) be considered. Extended and
frequent monitoring for
Fentanyl (5 g/kg single dose) In an independent published study, respiratory depression and other
Fentanyl AUC0- 1.34-fold opiate-associated adverse
reactions is recommended.
Opioid receptor antagonists
Naloxegol Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
naloxegol.
Oral contraceptives
Oral Contraceptives* Ethinylestradiol Cmax 36% Monitoring for adverse reactions
[CYP3A4 substrate; CYP2C19 Ethinylestradiol AUC 61% related to oral contraceptives, in
inhibitor] Norethisterone Cmax 15% addition to those for
Norethisterone/ethinylestradiol Norethisterone AUC 53% voriconazole, is recommended.
(1 mg/0.035 mg QD) Voriconazole Cmax 14%
Voriconazole AUC 46%
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) diclofenac (HOS-085903) ibuprofen (HOS-087884) methadone (HOS-086198) eplerenone (HOS-089050) oxycodone (HOS-109487) finerenone (HOS-109430) naloxegol (HOS-109428) hydrocodone (HOS-109488) naloxone (HOS-109490) fentanyl (HOS-086196) sufentanil (HOS-109489)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 8ddbb18c489ccc11c6814ac36e2fb24fd816c63d5b15490877a83dbf46e7d7f5 · Zeichen 27474–31780 im Abschnitt
Wechselwirkungen · Vfend
VFEND 200 mg powder for solution for infusion · Abschnitt 4.5 · PDF-Seite 48–49
HOS-109554 · Präparat HOS-093201
48
Non-steroidal selective mineralocorticoid receptor (MR) antagonists
Finerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
finerenone.
Eplerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
eplerenone.
Non-steroidal anti-inflammatory drugs (NSAIDs)
[CYP2C9 substrates] Frequent monitoring for adverse
S-Ibuprofen Cmax 20% reactions and toxicity related to
Ibuprofen (400 mg single dose) S-Ibuprofen AUC0- 100% NSAIDs is recommended. Dose
reduction of NSAIDs may be
Diclofenac (50 mg single dose) Diclofenac Cmax 114% needed.
Diclofenac AUC0- 78%
Opioids
Long-Acting Opiates In an independent published study, Dose reduction in oxycodone and
[CYP3A4 substrates] Oxycodone Cmax 1.7-fold other long-acting opiates
Oxycodone AUC0- 3.6-fold metabolised by CYP3A4
Oxycodone (10 mg single (e.g., hydrocodone) should be
dose) considered. Frequent monitoring
for opiate-associated adverse
reactions may be necessary.
Methadone (32-100 mg QD) R-methadone (active) Cmax 31% Frequent monitoring for adverse
[CYP3A4 substrate] R-methadone (active) AUC 47% reactions and toxicity related to
S-methadone Cmax 65% methadone, including QTc
S-methadone AUC 103% prolongation, is recommended.
Dose reduction of methadone
may be needed.
Short-acting Opiates Dose reduction of alfentanil,
[CYP3A4 substrates] fentanyl and other short-acting
opiates similar in structure to
Alfentanil (20 μg/kg single In an independent published study, alfentanil and metabolised by
dose, with concomitant Alfentanil AUC0- 6-fold CYP3A4 (e.g., sufentanil) should
naloxone) be considered. Extended and
frequent monitoring for
Fentanyl (5 g/kg single dose) In an independent published study, respiratory depression and other
Fentanyl AUC0- 1.34-fold opiate-associated adverse
reactions is recommended.
Opioid receptor antagonists
Naloxegol Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
naloxegol.
Oral contraceptives
Oral Contraceptives* Ethinylestradiol Cmax 36% Monitoring for adverse reactions
[CYP3A4 substrate; CYP2C19 Ethinylestradiol AUC 61% related to oral contraceptives, in
inhibitor] Norethisterone Cmax 15% addition to those for
Norethisterone/ethinylestradiol Norethisterone AUC 53% voriconazole, is recommended.
(1 mg/0.035 mg QD) Voriconazole Cmax 14%
Voriconazole AUC 46%
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) diclofenac (HOS-085903) ibuprofen (HOS-087884) methadone (HOS-086198) eplerenone (HOS-089050) oxycodone (HOS-109487) finerenone (HOS-109430) naloxegol (HOS-109428) hydrocodone (HOS-109488) naloxone (HOS-109490) fentanyl (HOS-086196) sufentanil (HOS-109489)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage e6233d476ccce7daca52d1dd2aaaa91e8c3161bd371e92e18ca8a2257625f3c2 · Zeichen 27978–32284 im Abschnitt
Wechselwirkungen · Vfend
VFEND 40 mg/ml powder for oral suspension · Abschnitt 4.5 · PDF-Seite 80–81
HOS-109619 · Präparat HOS-093201
80
Non-steroidal selective mineralocorticoid receptor (MR) antagonists
Finerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
finerenone.
Eplerenone Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
eplerenone.
Non-steroidal anti-inflammatory drugs (NSAIDs)
[CYP2C9 substrates] Frequent monitoring for adverse
S-Ibuprofen Cmax 20% reactions and toxicity related to
Ibuprofen (400 mg single dose) S-Ibuprofen AUC0- 100% NSAIDs is recommended. Dose
reduction of NSAIDs may be
Diclofenac (50 mg single dose) Diclofenac Cmax 114% needed.
Diclofenac AUC0- 78%
Opioids
Long-Acting Opiates In an independent published study, Dose reduction in oxycodone and
[CYP3A4 substrates] Oxycodone Cmax 1.7-fold other long-acting opiates
Oxycodone AUC0- 3.6-fold metabolised by CYP3A4
Oxycodone (10 mg single (e.g., hydrocodone) should be
dose) considered. Frequent monitoring
for opiate-associated adverse
reactions may be necessary.
Methadone (32-100 mg QD) R-methadone (active) Cmax 31% Frequent monitoring for adverse
[CYP3A4 substrate] R-methadone (active) AUC 47% reactions and toxicity related to
S-methadone Cmax 65% methadone, including QTc
S-methadone AUC 103% prolongation, is recommended.
Dose reduction of methadone
may be needed.
Short-acting Opiates Dose reduction of alfentanil,
[CYP3A4 substrates] fentanyl and other short-acting
opiates similar in structure to
Alfentanil (20 μg/kg single In an independent published study, alfentanil and metabolised by
dose, with concomitant Alfentanil AUC0- 6-fold CYP3A4 (e.g., sufentanil) should
naloxone) be considered. Extended and
frequent monitoring for
Fentanyl (5 g/kg single dose) In an independent published study, respiratory depression and other
Fentanyl AUC0- 1.34-fold opiate-associated adverse
reactions is recommended.
Opioid receptor antagonists
Naloxegol Although not studied, voriconazole Contraindicated (see section
[CYP3A4 substrate] is likely to significantly increase 4.3)
the plasma concentrations of
naloxegol.
Oral contraceptives
Oral Contraceptives* Ethinylestradiol Cmax 36% Monitoring for adverse reactions
[CYP3A4 substrate; CYP2C19 Ethinylestradiol AUC 61% related to oral contraceptives, in
inhibitor] Norethisterone Cmax 15% addition to those for
Norethisterone/ethinylestradiol Norethisterone AUC 53% voriconazole, is recommended.
(1 mg/0.035 mg QD) Voriconazole Cmax 14%
Voriconazole AUC 46%
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) diclofenac (HOS-085903) ibuprofen (HOS-087884) methadone (HOS-086198) eplerenone (HOS-089050) oxycodone (HOS-109487) finerenone (HOS-109430) naloxegol (HOS-109428) hydrocodone (HOS-109488) naloxone (HOS-109490) fentanyl (HOS-086196) sufentanil (HOS-109489)
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Version 2026-07-21T15:15:00Z · SHA-256 e91b23f050e51d641bef6be84ca7a49bb0e71d249b5c23f29243dda478d37eaf · Passage 5c1a7a3fda98976f51693be4906d67df598ab85a4fcf5f8cd51e8c0fe387196a · Zeichen 27504–31810 im Abschnitt
Wechselwirkungen · Glivec
Glivec 100 mg film-coated tablets Glivec 400 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11
HOS-110226 · Präparat HOS-093339
Imatinib increases the mean Cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold,
respectively, indicating an inhibition of the CYP3A4 by imatinib. Therefore, caution is recommended
when administering Glivec with CYP3A4 substrates with a narrow therapeutic window (e.g.
cyclosporine, pimozide, tacrolimus, sirolimus, ergotamine, diergotamine, fentanyl, alfentanil,
terfenadine, bortezomib, docetaxel and quinidine). Glivec may increase plasma concentration of other
CYP3A4 metabolised drugs (e.g. triazolo-benzodiazepines, dihydropyridine calcium channel blockers,
certain HMG-CoA reductase inhibitors, i.e. statins, etc.).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) simvastatin (HOS-086158) quinidine (HOS-085593) calcium (HOS-085615) docetaxel (HOS-084505) tacrolimus (HOS-085202) bortezomib (HOS-110227) pimozide (HOS-085600) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) terfenadine (HOS-085607) cyclosporine (HOS-084512)
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Wechselwirkungen · Emend
EMEND 125 mg hard capsules EMEND 80 mg hard capsules · Abschnitt 4.5 · PDF-Seite 5
HOS-112511 · Präparat HOS-093697
Effect aprepitant on the pharmacokinetics of other active substances
CYP3A4 inhibition
As a moderate inhibitor of CYP3A4, aprepitant (125 mg/80 mg) can increase plasma concentrations of
co-administered active substances that are metabolised through CYP3A4. The total exposure of orally
administered CYP3A4 substrates may increase up to approximately 3-fold during the 3-day treatment
with EMEND; the effect of aprepitant on the plasma concentrations of intravenously administered
CYP3A4 substrates is expected to be smaller. EMEND must not be used concurrently with pimozide,
terfenadine, astemizole, or cisapride (see section 4.3). Inhibition of CYP3A4 by aprepitant could result
in elevated plasma concentrations of these active substances, potentially causing serious or
life-threatening reactions. Caution is advised during concomitant administration of EMEND and orally
administered active substances that are metabolised primarily through CYP3A4 and with a narrow
therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine,
ergotamine, fentanyl, and quinidine (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) cisapride (HOS-085610) quinidine (HOS-085593) tacrolimus (HOS-085202) pimozide (HOS-085600) everolimus (HOS-086310) astemizole (HOS-085608) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) terfenadine (HOS-085607) cyclosporine (HOS-084512)
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Version 2025-10-24T11:24:00Z · SHA-256 afd6062a51e59b36e448c9117685894e4529fcde2f5e673f4401f91bb32d7081 · Passage 95169de188fddd2d62217733cbc8b18b68fe7db2d6460ff4dc5aa2b0e655690d · Zeichen 490–1616 im Abschnitt
Wechselwirkungen · Emend
EMEND 125 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 22
HOS-112572 · Präparat HOS-093697
Effect of aprepitant on the pharmacokinetics of other active substances
CYP3A4 inhibition
As a moderate inhibitor of CYP3A4, aprepitant (125 mg/80 mg) can increase plasma concentrations of
co-administered active substances that are metabolised through CYP3A4. The total exposure of orally
administered CYP3A4 substrates may increase up to approximately 3-fold during the 3-day treatment
with EMEND; the effect of aprepitant on the plasma concentrations of intravenously administered
CYP3A4 substrates is expected to be smaller. EMEND must not be used concurrently with pimozide,
terfenadine, astemizole, or cisapride (see section 4.3). Inhibition of CYP3A4 by aprepitant could result
in elevated plasma concentrations of these active substances, potentially causing serious or
life-threatening reactions. Caution is advised during concomitant administration of EMEND and orally
administered active substances that are metabolised primarily through CYP3A4 and with a narrow
therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine,
ergotamine, fentanyl, and quinidine (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) cisapride (HOS-085610) quinidine (HOS-085593) tacrolimus (HOS-085202) pimozide (HOS-085600) everolimus (HOS-086310) astemizole (HOS-085608) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) terfenadine (HOS-085607) cyclosporine (HOS-084512)
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Version 2025-10-24T11:24:00Z · SHA-256 afd6062a51e59b36e448c9117685894e4529fcde2f5e673f4401f91bb32d7081 · Passage b50d17ed63c48d4d594d584aa63f6b0c29730ab2069a1d8a4a7e4e6f403046fb · Zeichen 431–1560 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 14–15
HOS-116357 · Präparat HOS-094447
14
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38% ‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of boosted PREZISTA and the
darunavir Cmax ↓ 21%
Lopinavir/ritonavir combination product
lopinavir AUC ↔
533/133.3 mg twice daily lopinavir/ritonavir is
lopinavir Cmin ↑ 13% contraindicated (see section 4.3).
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with boosted
darunavir, ritonavir concentrations were PREZISTA.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
PREZISTA is expected to increase PREZISTA and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with boosted
is mediated via CYP3A, and may as such PREZISTA may require to lower
be inhibited by boosted PREZISTA. the dose of alfentanil and requires
monitoring for risks of prolonged
or delayed respiratory depression.
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. Boosted PREZISTA is Caution is warranted and
Flecainide expected to increase these antiarrhythmic therapeutic concentration
Lidocaine (systemic) plasma concentrations. monitoring, if available, is
Mexiletine (CYP3A and/or CYP2D6 inhibition) recommended for these
Propafenone antiarrhythmics when
co-administered with boosted
PREZISTA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) propafenone (HOS-084530) protease (HOS-085623) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) disopyramide (HOS-085595) maraviroc (HOS-086186) ritonavir (HOS-084521)
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Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 79aee1bbebf74d1fc7eeb1f64d47f744ae971edc2caad3984bd946f3f467a703 · Zeichen 24118–27577 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 56
HOS-116515 · Präparat HOS-094447
Saquinavir: comparison of
saquinavir/ritonavir 1,000/100 mg twice
daily vs. saquinavir/darunavir/ritonavir
1,000/400/100 mg twice daily
Darunavir: comparison of
darunavir/ritonavir 400/100 mg twice
daily vs. darunavir/ritonavir 400/100 mg
in combination with saquinavir 1,000 mg
twice daily.
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38%‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of PREZISTA co-administered
darunavir Cmax ↓ 21%
with low dose ritonavir and the
lopinavir AUC ↔
Lopinavir/ritonavir combination product
533/133.3 mg twice daily lopinavir Cmin ↑ 13% lopinavir/ritonavir is
lopinavir Cmax ↑ 11% contraindicated (see section 4.3).
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with PREZISTA
darunavir, ritonavir concentrations were with low dose ritonavir.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of PREZISTA
PREZISTA is expected to increase with low dose ritonavir and
alfuzosin plasma concentrations. alfuzosin is contraindicated (see
(CYP3A inhibition) section 4.3).
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with
is mediated via CYP3A, and may as such PREZISTA and low dose ritonavir
be inhibited by PREZISTA may require to lower the dose of
co-administered with low dose ritonavir. alfentanil and requires monitoring
for risks of prolonged or delayed
respiratory depression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) protease (HOS-085623) saquinavir (HOS-084522) maraviroc (HOS-086186) ritonavir (HOS-084521)
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Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage fee9104200efc5fedbf726f44b3ea40b4fea72494f0de60d64ad635836e51d2d · Zeichen 16855–20345 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 95–96
HOS-116606 · Präparat HOS-094447
95
Saquinavir # It is not recommended to combine
darunavir AUC ↓ 26%
1,000 mg twice daily #
darunavir Cmin ↓ 42% PREZISTA co-administered with
#
darunavir Cmax ↓ 17% low dose ritonavir with saquinavir.
saquinavir AUC ↓ 6%
saquinavir Cmin ↓ 18% PREZISTA co-administered with
cobicistat should not be used in
saquinavir Cmax ↓ 6%
combination with another
antiretroviral agent that requires
Saquinavir: comparison of
pharmacoenhancement by means
saquinavir/ritonavir 1,000/100 mg twice
of co-administration with an
daily vs. saquinavir/darunavir/ritonavir
inhibitor of CYP3A4 (see section
1,000/400/100 mg twice daily
4.5).
Darunavir: comparison of
darunavir/ritonavir 400/100 mg twice
daily vs. darunavir/ritonavir 400/100 mg
in combination with saquinavir 1,000 mg
twice daily.
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38%‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of boosted PREZISTA and the
darunavir Cmax ↓ 21%
Lopinavir/ritonavir combination product
lopinavir AUC ↔
533/133.3 mg twice daily lopinavir/ritonavir is
lopinavir Cmin ↑ 13% contraindicated (see section 4.3).
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with boosted
darunavir, ritonavir concentrations were PREZISTA.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
PREZISTA is expected to increase PREZISTA and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with boosted
is mediated via CYP3A, and may as such PREZISTA may require to lower
be inhibited by boosted PREZISTA. the dose of alfentanil and requires
monitoring for risks of prolonged
or delayed respiratory depression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) alfuzosin (HOS-086139) lopinavir (HOS-086269) protease (HOS-085623) cobicistat (HOS-088111) saquinavir (HOS-084522) maraviroc (HOS-086186) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 1eb808e8ac29f3c76db8fe318c2ee85ee0f022f66cbb4ebf8bdc633036fd5092 · Zeichen 22422–27069 im Abschnitt
Wechselwirkungen · Ivemend
IVEMEND 150 mg powder for solution for infusion. · Abschnitt 4.5 · PDF-Seite 7
HOS-117436 · Präparat HOS-094609
Effect of fosaprepitant on the pharmacokinetics of other active substances
CYP3A4 inhibition
As a weak inhibitor of CYP3A4, the fosaprepitant 150 mg single dose can cause a transient increase in
plasma concentrations of co-administered active substances that are metabolised through CYP3A4.
The total exposure of CYP3A4 substrates may increase up to 2-fold on Days 1 and 2 after co-
administration with a single 150 mg fosaprepitant dose. Fosaprepitant must not be used concurrently
with pimozide, terfenadine, astemizole, or cisapride. Inhibition of CYP3A4 by fosaprepitant could
result in elevated plasma concentrations of these active substances, potentially causing serious or life-
threatening reactions (see section 4.3). Caution is advised during concomitant administration of
fosaprepitant and active substances that are metabolised primarily through CYP3A4 and with a narrow
therapeutic range, such as ciclosporin, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine,
ergotamine, fentanyl, and quinidine (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) cisapride (HOS-085610) quinidine (HOS-085593) tacrolimus (HOS-085202) pimozide (HOS-085600) everolimus (HOS-086310) astemizole (HOS-085608) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) terfenadine (HOS-085607)
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Version 2025-11-05T14:57:00Z · SHA-256 9e19bc1fa93d788029c9702424aacb9622fe408d4db1dbe0bc9e0ad1d449f179 · Passage a3d72089ac8f22106e064a5b53eea12b3862e18df89fd2a25aacaa574d8c8b78 · Zeichen 1419–2458 im Abschnitt
Wechselwirkungen · Tasigna
Tasigna 50 mg hard capsules Tasigna 150 mg hard capsules Tasigna 200 mg hard capsules · Abschnitt 4.5 · PDF-Seite 11
HOS-118214 · Präparat HOS-094783
In CML patients, nilotinib administered at 400 mg twice daily for 12 days increased the systemic
exposure (AUC and Cmax) of oral midazolam (a substrate of CYP3A4) 2.6-fold and 2.0-fold,
respectively. Nilotinib is a moderate CYP3A4 inhibitor. As a result, the systemic exposure of other
medicinal products primarily metabolised by CYP3A4 (e.g. certain HMG-CoA reductase inhibitors)
may be increased when co-administered with nilotinib. Appropriate monitoring and dose adjustment
may be necessary for medicinal products that are CYP3A4 substrates and have a narrow therapeutic
index (including but not limited to alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl,
sirolimus and tacrolimus) when co-administered with nilotinib.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) tacrolimus (HOS-085202) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) cyclosporine (HOS-084512) dihydroergotamine (HOS-086152) midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-12-17T17:21:00Z · SHA-256 efb2ca2c5c7d9a0e740759217e71ff7f08cf3763f8c41f5c02f5d10733d67b3a · Passage 23ad3532a1eda3034de9d8d8de01bc2192023dd8f9a385ed2dc7a67e7e3800d5 · Zeichen 4158–4898 im Abschnitt
Wechselwirkungen · Halaven
HALAVEN 0.44 mg/ml solution for injection · Abschnitt 4.5 · PDF-Seite 5
HOS-124158 · Präparat HOS-095809
In vitro data indicate that eribulin is a mild inhibitor of the important drug metabolising enzyme
CYP3A4. No in vivo data are available. Caution and monitoring for adverse events is recommended
with concomitant use of substances that have a narrow therapeutic window and that are eliminated
mainly via CYP3A4-mediated metabolism (e.g. alfentanil, cyclosporine, ergotamine, fentanyl,
pimozide, quinidine, sirolimus, tacrolimus).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) quinidine (HOS-085593) tacrolimus (HOS-085202) pimozide (HOS-085600) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) cyclosporine (HOS-084512)
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Version 2024-10-11T15:05:00Z · SHA-256 31249ef6210ad802092fdf0a12213640c232c7a0e17f9862972975afd370495d · Passage ef51fe4aa5995b880a76d762223f1cc95b253a66b1d1135790e0af0f2a9d33e7 · Zeichen 633–1061 im Abschnitt
Wechselwirkungen · Dexdor
Dexdor 100 micrograms/ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 6
HOS-125024 · Präparat HOS-095977
Co-administration of dexmedetomidine with anaesthetics, sedatives, hypnotics, and opioids is likely to
lead to an enhancement of effects, including sedative, anaesthetic and cardiorespiratory effects.
Specific studies have confirmed enhanced effects with isoflurane, propofol, alfentanil, and midazolam.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) propofol (HOS-109374) isoflurane (HOS-109378) lead (HOS-085592) midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-28T09:44:00Z · SHA-256 cd035991ab93d6c1080cd13ba388206127ed14465372795eff9b55abc90e6db0 · Passage 6589f23bd68cf8fed21e56c94efefb7d7ec8ac3d5bc79daed0d9eb23664b42b4 · Zeichen 57–360 im Abschnitt
Wechselwirkungen · Dexdor
Dexdor 100 micrograms/ml concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 6–7
HOS-125025 · Präparat HOS-095977
6
No pharmacokinetic interactions between dexmedetomidine and isoflurane, propofol, alfentanil and
midazolam have been demonstrated. However, due to possible pharmacodynamic interactions, when
co-administered with dexmedetomidine, a reduction in dosage of dexmedetomidine or the concomitant
anaesthetic, sedative, hypnotic or opioid may be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) propofol (HOS-109374) isoflurane (HOS-109378) midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-28T09:44:00Z · SHA-256 cd035991ab93d6c1080cd13ba388206127ed14465372795eff9b55abc90e6db0 · Passage 94b605a1f4ed4e56f6245362efe6214e23248763e9384d8603c81bf38d900482 · Zeichen 414–764 im Abschnitt
Wechselwirkungen · Xalkori
XALKORI 200 mg hard capsules XALKORI 250 mg hard capsules XALKORI 20 mg granules in capsules for opening XALKORI 50 mg granules in capsules for opening XALKORI 150 mg granules in capsules for opening · Abschnitt 4.5 · PDF-Seite 15
HOS-126280 · Präparat HOS-096239
Agents whose plasma concentrations may be altered by crizotinib
Following 28 days of crizotinib dosing at 250 mg taken twice daily in cancer patients, the oral
midazolam AUCinf was 3.7-fold of those seen when midazolam was administered alone, suggesting
that crizotinib is a moderate inhibitor of CYP3A. Therefore, coadministration of crizotinib with
CYP3A substrates with narrow therapeutic indices, including but not limited to alfentanil, cisapride,
cyclosporine, ergot derivatives, fentanyl, pimozide, quinidine, sirolimus and tacrolimus should be
avoided (see section 4.4). If the combination is needed, then close clinical monitoring should be
exercised.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) cisapride (HOS-085610) quinidine (HOS-085593) tacrolimus (HOS-085202) pimozide (HOS-085600) sirolimus (HOS-085172) fentanyl (HOS-086196) cyclosporine (HOS-084512) midazolam (HOS-086167)
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Version 2025-09-17T11:44:00Z · SHA-256 ef70dd9e8f617f709767e5bd4c7044eb23893a7ac40281434ebfa2fb8fb4e3d5 · Passage 152f20907a07570e5b1c10638939fd33f79f5210816512fd5ea739aa25c95a63 · Zeichen 3814–4474 im Abschnitt
Wechselwirkungen · Akynzeo
Akynzeo 300 mg/0.5 mg hard capsules · Abschnitt 4.5 · PDF-Seite 5–6
HOS-130699 · Präparat HOS-096947
Netupitant is mainly metabolised by CYP3A4; therefore, co-administration with medicinal products
that inhibit or induce CYP3A4 activity may influence plasma concentrations of netupitant.
Consequently, concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole)
should be approached with caution and concomitant administration with strong CYP3A4 inducers
(e.g., rifampicin) should be avoided. Moreover, this medicinal product should be used with caution in
patients receiving concomitant orally administered active substances with a narrow therapeutic range
that are primarily metabolised by CYP3A4, such as cyclosporine, tacrolimus, sirolimus, everolimus,
5
alfentanil, diergotamine, ergotamine, fentanyl, and quinidine.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) ketoconazole (HOS-084513) quinidine (HOS-085593) tacrolimus (HOS-085202) everolimus (HOS-086310) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) cyclosporine (HOS-084512)
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Version 2026-08-25T11:52:00Z · SHA-256 d3ff78e9e4d5b08bc98e527fab724082b02f5be1899a4d4f9c683d723854e46c · Passage feff48dcbd1e3a397dca67ff11c9be3c5588e9ca8708f2aed816cac8522d3598 · Zeichen 3768–4558 im Abschnitt
Wechselwirkungen · Akynzeo
Akynzeo 235 mg/0.25 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 21–22
HOS-130740 · Präparat HOS-096947
Netupitant is mainly metabolised by CYP3A4; therefore, co-administration with medicinal products
that inhibit or induce CYP3A4 activity may influence plasma concentrations of netupitant.
Consequently, concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole) should
21
be approached with caution and concomitant administration with strong CYP3A4 inducers (e.g.,
rifampicin) should be avoided. Moreover, this medicinal product should be used with caution in
patients receiving concomitant orally administered active substances with a narrow therapeutic range
that are primarily metabolised by CYP3A4, such as cyclosporine, tacrolimus, sirolimus, everolimus,
alfentanil, diergotamine, ergotamine, fentanyl, and quinidine.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) ketoconazole (HOS-084513) quinidine (HOS-085593) tacrolimus (HOS-085202) everolimus (HOS-086310) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) cyclosporine (HOS-084512)
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Version 2026-08-25T11:52:00Z · SHA-256 d3ff78e9e4d5b08bc98e527fab724082b02f5be1899a4d4f9c683d723854e46c · Passage 6d43f4270698847344eb1b734abf13ad2bf8f680bba27f36d2af8f239618c6f4 · Zeichen 3798–4588 im Abschnitt
Wechselwirkungen · Akynzeo
Akynzeo 235 mg/0.25 mg concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 39–40
HOS-130783 · Präparat HOS-096947
Netupitant is mainly metabolised by CYP3A4; therefore, co-administration with medicinal products
that inhibit or induce CYP3A4 activity may influence plasma concentrations of netupitant.
Consequently, concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole) should
39
be approached with caution and concomitant administration with strong CYP3A4 inducers (e.g.,
rifampicin) should be avoided. Moreover, this medicinal product should be used with caution in
patients receiving concomitant orally administered active substances with a narrow therapeutic range
that are primarily metabolised by CYP3A4, such as cyclosporine, tacrolimus, sirolimus, everolimus,
alfentanil, diergotamine, ergotamine, fentanyl, and quinidine.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfentanil (HOS-109375) ketoconazole (HOS-084513) quinidine (HOS-085593) tacrolimus (HOS-085202) everolimus (HOS-086310) sirolimus (HOS-085172) fentanyl (HOS-086196) ergotamine (HOS-086154) cyclosporine (HOS-084512)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-25T11:52:00Z · SHA-256 d3ff78e9e4d5b08bc98e527fab724082b02f5be1899a4d4f9c683d723854e46c · Passage 39f90840a2362fc69f04f921682545e70a0354d1c40c395de423a823b9c589e3 · Zeichen 3799–4589 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.