Wechselwirkungen · Xyrem
Xyrem 500 mg/mL oral solution · Abschnitt 4.5 · PDF-Seite 7
HOS-113661 · Präparat HOS-093953
Antidepressants Drug interaction studies in healthy adults demonstrated no pharmacokinetic interactions between sodium oxybate (single dose of 2.25 g) and the antidepressants protriptyline hydrochloride (single dose of 10 mg) and duloxetine (60 mg at steady state). No additional effect on sleepiness was observed when comparing single doses of sodium oxybate alone (2.25 g) and sodium oxybate (2.25 g) in combination with duloxetine (60 mg at steady state). Antidepressants have been used in the treatment of cataplexy. A possible additive effect of antidepressants and sodium oxybate cannot be excluded. The rate of adverse reactions has increased when sodium oxybate is co-administered with tricyclic antidepressants.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): duloxetine (HOS-089666) protriptyline hydrochloride (HOS-113662)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-12T16:47:00Z · SHA-256 458b7a20ee31b89a8296f6c62f1482472a82c1e2139396dca882dd3f5b361fd3 · Passage 33b240914de9372f517a3b4a815ebb8b65da3d5d185463d4029eb2e31e09ea89 · Zeichen 1555–2275 im Abschnitt