Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Wechselwirkungen · Xolair
Xolair 75 mg solution for injection in pre-filled syringe Xolair 75 mg solution for injection in pre-filled pen · Abschnitt 4.5 · PDF-Seite 8
HOS-114047 · Präparat HOS-094023
In clinical studies omalizumab was used in conjunction with intranasal mometasone spray as per
protocol. Other commonly used concomitant medicinal products included other intranasal
corticosteroids, bronchodilators, antihistamines, leukotriene receptor antagonists,
adrenergics/sympathomimetics and local nasal anaesthetics. There was no indication that the safety of
omalizumab was altered by the concomitant use of these other commonly used medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): mometasone (HOS-114048)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-08T15:13:00Z · SHA-256 cc2feebb2bc2e7cb8321315e3dd8c400946e4ce10b94103d08ea7be0f9ed4f84 · Passage 4be02fdd4fdcf7ce4703fb9212c95487f1848a88071d8f2a18a3b2ec64c439c2 · Zeichen 1413–1875 im Abschnitt
Wechselwirkungen · Xolair
Xolair 150 mg solution for injection in pre-filled syringe Xolair 300 mg solution for injection in pre-filled syringe Xolair 150 mg solution for injection in pre-filled pen Xolair 300 mg solution for injection in pre-filled pen · Abschnitt 4.5 · PDF-Seite 29
HOS-114070 · Präparat HOS-094023
In clinical studies omalizumab was used in conjunction with intranasal mometasone spray as per
protocol. Other commonly used concomitant medicinal products included other intranasal
corticosteroids, bronchodilators antihistamines, leukotriene receptor antagonists,
adrenergics/sympathomimetics and local nasal anesthetics. There was no indication that the safety of
omalizumab was altered by the concomitant use of these other commonly used medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): mometasone (HOS-114048)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-08T15:13:00Z · SHA-256 cc2feebb2bc2e7cb8321315e3dd8c400946e4ce10b94103d08ea7be0f9ed4f84 · Passage c1d59ef6114fed8fd98ebaebb382c4fbc40a93b033d784639587435868936f91 · Zeichen 1474–1934 im Abschnitt
Wechselwirkungen · Xolair
Xolair 75 mg powder and solvent for solution for injection · Abschnitt 4.5 · PDF-Seite 53
HOS-114103 · Präparat HOS-094023
In clinical studies omalizumab was used in conjunction with intranasal mometasone spray as per
protocol. Other commonly used concomitant medicinal products included other intranasal
corticosteroids, bronchodilators, antihistamines, leukotriene receptor antagonists,
adrenergics/sympathomimetics and local nasal anaesthetics. There was no indication that the safety of
omalizumab was altered by the concomitant use of these other commonly used medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): mometasone (HOS-114048)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-08T15:13:00Z · SHA-256 cc2feebb2bc2e7cb8321315e3dd8c400946e4ce10b94103d08ea7be0f9ed4f84 · Passage 4be02fdd4fdcf7ce4703fb9212c95487f1848a88071d8f2a18a3b2ec64c439c2 · Zeichen 1413–1875 im Abschnitt
Wechselwirkungen · Xolair
Xolair 150 mg powder and solvent for solution for injection · Abschnitt 4.5 · PDF-Seite 72
HOS-114125 · Präparat HOS-094023
In clinical studies omalizumab was used in conjunction with intranasal mometasone spray as per
protocol. Other commonly used concomitant medicinal products included other intranasal
corticosteroids, bronchodilators, antihistamines, leukotriene receptor antagonists,
adrenergics/sympathomimetics and local nasal anaesthetics. There was no indication that the safety of
omalizumab was altered by the concomitant use of these other commonly used medicinal products.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): mometasone (HOS-114048)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-08T15:13:00Z · SHA-256 cc2feebb2bc2e7cb8321315e3dd8c400946e4ce10b94103d08ea7be0f9ed4f84 · Passage 4be02fdd4fdcf7ce4703fb9212c95487f1848a88071d8f2a18a3b2ec64c439c2 · Zeichen 1417–1879 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 19–20
HOS-116394 · Präparat HOS-094447
19
ANTIPSYCHOTICS/NEUROLEPTICS
Quetiapine Not studied. Boosted PREZISTA is Concomitant administration of
expected to increase these antipsychotic boosted PREZISTA and quetiapine
plasma concentrations. is contraindicated as it may
(CYP3A inhibition) increase quetiapine-related
toxicity. Increased concentrations
of quetiapine may lead to coma
(see section 4.3).
Perphenazine Not studied. Boosted PREZISTA is A dose decrease may be needed for
Risperidone expected to increase these antipsychotic these drugs when co-administered
Thioridazine plasma concentrations. with boosted PREZISTA.
(CYP3A, CYP2D6 and/or P-gp
Lurasidone inhibition) Concomitant administration of
Pimozide boosted PREZISTA and
Sertindole lurasidone, pimozide or sertindole
is contraindicated (see section 4.3).
β-BLOCKERS
Carvedilol Not studied. Boosted PREZISTA is Clinical monitoring is
Metoprolol expected to increase these β-blocker recommended when
Timolol plasma concentrations. co-administering boosted
(CYP2D6 inhibition) PREZISTA with β-blockers. A
lower dose of the β-blocker should
be considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Not studied. Boosted PREZISTA can be Clinical monitoring of therapeutic
Diltiazem expected to increase the plasma and adverse effects is
Felodipine concentrations of calcium channel recommended when these
Nicardipine blockers. medicines are concomitantly
Nifedipine (CYP3A and/or CYP2D6 inhibition) administered with boosted
Verapamil PREZISTA.
CORTICOSTEROIDS
Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of boosted
metabolised by CYP3A ritonavir 100 mg capsules twice daily PREZISTA and corticosteroids (all
(including were co-administered with 50 g routes of administration) that are
betamethasone, intranasal fluticasone propionate (4 times metabolised by CYP3A may
budesonide, fluticasone, daily) for 7 days in healthy subjects, increase the risk of development of
mometasone, prednisone, fluticasone propionate plasma systemic corticosteroid effects,
triamcinolone) concentrations increased significantly, including Cushing’s syndrome and
whereas the intrinsic cortisol levels adrenal suppression.
decreased by approximately 86% (90%
CI 82-89%). Greater effects may be Co-administration with CYP3A-
expected when fluticasone is inhaled. metabolised corticosteroids is not
Systemic corticosteroid effects including recommended unless the potential
Cushing’s syndrome and adrenal benefit to the patient outweighs the
suppression have been reported in risk, in which case patients should
patients receiving ritonavir and inhaled or be monitored for systemic
intranasally administered fluticasone. The corticosteroid effects.
effects of high fluticasone systemic
exposure on ritonavir plasma levels are Alternative corticosteroids which
unknown. are less dependent on CYP3A
metabolism e.g. beclomethasone
Other corticosteroids: interaction not should be considered, particularly
studied. Plasma concentrations of these for long term use.
medicinal products may be increased
when co-administered with boosted
PREZISTA, resulting in reduced serum
cortisol concentrations.
Dexamethasone Not studied. Dexamethasone may Systemic dexamethasone should
(systemic) decrease plasma concentrations of be used with caution when
darunavir. combined with boosted
(CYP3A induction) PREZISTA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) lead (HOS-085592) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 06bb26e6737c57cc3c74485aceb2076b3feb5ff5bad566ac99081f05e0924029 · Zeichen 52002–57572 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 61–62
HOS-116527 · Präparat HOS-094447
61
Perphenazine Not studied. PREZISTA is expected to A dose decrease may be needed for
Risperidone increase these antipsychotic plasma these drugs when co-administered
Thioridazine concentrations. with PREZISTA co-administered
(CYP3A, CYP2D6 and/or P-gp with low dose ritonavir.
inhibition)
Lurasidone Concomitant administration of
Pimozide PREZISTA with low dose
Sertindole ritonavir and lurasidone, pimozide
or sertindole is contraindicated
(see section 4.3).
β-BLOCKERS
Carvedilol Not studied. PREZISTA is expected to Clinical monitoring is
Metoprolol increase these β-blocker plasma recommended when
Timolol concentrations. co-administering PREZISTA with
(CYP2D6 inhibition) β-blockers. A lower dose of the
β-blocker should be considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Not studied. PREZISTA co-administered Clinical monitoring of therapeutic
Diltiazem with low dose ritonavir can be expected and adverse effects is
Felodipine to increase the plasma concentrations of recommended when these
Nicardipine calcium channel blockers. medicines are concomitantly
Nifedipine (CYP3A and/or CYP2D6 inhibition) administered with PREZISTA with
Verapamil low dose ritonavir.
CORTICOSTEROIDS
Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of PREZISTA
metabolised by CYP3A ritonavir 100 mg capsules twice daily with low dose ritonavir and
(including were co-administered with 50 g corticosteroids (all routes of
betamethasone, intranasal fluticasone propionate (4 times administration) that are
budesonide, fluticasone, daily) for 7 days in healthy subjects, metabolised by CYP3A may
mometasone, prednisone, fluticasone propionate plasma increase the risk of development of
triamcinolone) concentrations increased significantly, systemic corticosteroid effects,
whereas the intrinsic cortisol levels including Cushing’s syndrome and
decreased by approximately 86% (90% adrenal suppression.
CI 82-89%). Greater effects may be
expected when fluticasone is inhaled. Co-administration with CYP3A-
Systemic corticosteroid effects including metabolised corticosteroids is not
Cushing’s syndrome and adrenal recommended unless the potential
suppression have been reported in benefit to the patient outweighs the
patients receiving ritonavir and inhaled or risk, in which case patients should
intranasally administered fluticasone. The be monitored for systemic
effects of high fluticasone systemic corticosteroid effects.
exposure on ritonavir plasma levels are
unknown. Alternative corticosteroids which
are less dependent on CYP3A
Other corticosteroids: interaction not metabolism e.g. beclomethasone
studied. Plasma concentrations of these should be considered, particularly
medicinal products may be increased for long term use.
when co-administered with PREZISTA
with low dose ritonavir, resulting in
reduced serum cortisol concentrations.
Dexamethasone Not studied. Dexamethasone may Systemic dexamethasone should
(systemic) decrease plasma concentrations of be used with caution when
darunavir. combined with PREZISTA
(CYP3A induction) co-administered with low dose
ritonavir.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 8b9ea54ec289adeef1a2f9f81165d44d84f0b8d5433cec6f77b7df8c89fd8286 · Zeichen 43290–48378 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 101–102
HOS-116617 · Präparat HOS-094447
101
ANTIPSYCHOTICS/NEUROLEPTICS
Quetiapine Not studied. Boosted PREZISTA is Concomitant administration of
expected to increase these antipsychotic boosted PREZISTA and quetiapine
plasma concentrations. is contraindicated as it may
(CYP3A inhibition) increase quetiapine-related
toxicity. Increased concentrations
of quetiapine may lead to coma
(see section 4.3).
Perphenazine Not studied. Boosted PREZISTA is A dose decrease may be needed for
Risperidone expected to increase these antipsychotic these drugs when co-administered
Thioridazine plasma concentrations. with boosted PREZISTA.
(CYP3A, CYP2D6 and/or P-gp
Lurasidone inhibition) Concomitant administration of
Pimozide boosted PREZISTA and
Sertindole lurasidone, pimozide or sertindole
is contraindicated (see section 4.3).
β-BLOCKERS
Carvedilol Not studied. Boosted PREZISTA is Clinical monitoring is
Metoprolol expected to increase these β-blocker recommended when
Timolol plasma concentrations. co-administering boosted
(CYP2D6 inhibition) PREZISTA with β-blockers. A
lower dose of the β-blocker should
be considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Not studied. Boosted PREZISTA can be Clinical monitoring of therapeutic
Diltiazem expected to increase the plasma and adverse effects is
Felodipine concentrations of calcium channel recommended when these
Nicardipine blockers. medicines are concomitantly
Nifedipine (CYP3A and/or CYP2D6 inhibition) administered with boosted
Verapamil PREZISTA.
CORTICOSTEROIDS
Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of boosted
metabolised by CYP3A ritonavir 100 mg capsules twice daily PREZISTA and corticosteroids (all
(including were co-administered with 50 g routes of administration) that are
betamethasone, intranasal fluticasone propionate (4 times metabolised by CYP3A may
budesonide, fluticasone, daily) for 7 days in healthy subjects, increase the risk of development of
mometasone, prednisone, fluticasone propionate plasma systemic corticosteroid effects,
triamcinolone) concentrations increased significantly, including Cushing’s syndrome and
whereas the intrinsic cortisol levels adrenal suppression.
decreased by approximately 86% (90%
CI 82-89%). Greater effects may be Co-administration with CYP3A-
expected when fluticasone is inhaled. metabolised corticosteroids is not
Systemic corticosteroid effects including recommended unless the potential
Cushing’s syndrome and adrenal benefit to the patient outweighs the
suppression have been reported in risk, in which case patients should
patients receiving ritonavir and inhaled or be monitored for systemic
intranasally administered fluticasone. The corticosteroid effects.
effects of high fluticasone systemic
exposure on ritonavir plasma levels are Alternative corticosteroids which
unknown. are less dependent on CYP3A
metabolism e.g. beclomethasone
Other corticosteroids: interaction not should be considered, particularly
studied. Plasma concentrations of these for long term use.
medicinal products may be increased
when co-administered with boosted
PREZISTA, resulting in reduced serum
cortisol concentrations.
Dexamethasone Not studied. Dexamethasone may Systemic dexamethasone should
(systemic) decrease plasma concentrations of be used with caution when
darunavir. combined with boosted
(CYP3A induction) PREZISTA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) lead (HOS-085592) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage ccb6e0bf9fbd4db134b19a5c68f5c32c6656fffa35e00c9b9b966f86c2226743 · Zeichen 51473–57044 im Abschnitt
Wechselwirkungen · Genvoya
Genvoya 150 mg/150 mg/200 mg/10 mg film-coated tablets Genvoya 90 mg/90 mg/120 mg/6 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 13–14
HOS-133968 · Präparat HOS-097520
13
Medicinal product by Effects on medicinal product Recommendation concerning
therapeutic areas levels. co-administration with Genvoya
Mean percent change in AUC,
Cmax, Cmin1
GLUCOCORTICOIDS
Corticosteroids
Corticosteroids primarily Interaction not studied with any of Concomitant use of Genvoya and
metabolised by CYP3A (including the components of Genvoya. corticosteroids that are metabolised
betamethasone, budesonide, by CYP3A (e.g. fluticasone
fluticasone, mometasone, Plasma concentrations of these propionate or other inhaled or nasal
prednisone, triamcinolone). medicinal products may be corticosteroids) may increase the
increased when co-administered risk of development of systemic
with Genvoya, resulting in reduced corticosteroid effects, including
serum cortisol concentrations. Cushing’s syndrome and adrenal
suppression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): triamcinolone (HOS-086333) fluticasone (HOS-108914) betamethasone (HOS-090066) budesonide (HOS-086332) mometasone (HOS-114048) propionate (HOS-108915) prednisone (HOS-084526)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2022-11-28T16:51:00Z · SHA-256 5b1a306ad5f7dd33700254558ee14691810f4eafdcf9d1256ccc229ad5e01997 · Passage 4acfffdad184917b98d978a921f68a1280a07b1ef57cf90080b742c333a4288d · Zeichen 20863–22145 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 17–18
HOS-134507 · Präparat HOS-097580
17
INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS
Medicinal products by Interaction Geometric mean change Recommendations concerning co-
therapeutic areas (%) administration
Perphenazine Not studied. Darunavir is expected to A dose decrease may be needed for
Risperidone increase these antipsychotic plasma these drugs when co-administered
Thioridazine concentrations. with darunavir co-administered with
(CYP3A, CYP2D6 and/or P-gp low dose ritonavir.
inhibition)
Lurasidone Pimozide Concomitant administration of
Sertindole darunavir with low dose ritonavir
and lurasidone, pimozide or
sertindole is contraindicated (see
section 4.3).
β-BLOCKERS
Carvedilol Not studied. Darunavir is expected to Clinical monitoring is
Metoprolol increase these β-blocker plasma recommended when co-
Timolol concentrations. administering darunavir with β-
(CYP2D6 inhibition) blockers. A lower dose of the β-
blocker should be considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Not studied. Darunavir co-administered Clinical monitoring of therapeutic
Diltiazem with low dose ritonavir can be and adverse effects is recommended
Felodipine expected to increase the plasma when these medicines are
Nicardipine concentrations of calcium channel concomitantly administered with
Nifedipine blockers. darunavir with low dose ritonavir.
Verapamil (CYP3A and/or CYP2D6 inhibition)
CORTICOSTEROIDS
Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of darunavir with
metabolised by CYP3A ritonavir 100 mg capsules twice daily low dose ritonavir and
(including betamethasone, were co-administered with 50 μg corticosteroids (all routes of
budesonide, fluticasone, intranasal fluticasone propionate (4 administration) that are metabolised
mometasone, prednisone, times daily) for 7 days in healthy by CYP3A may increase the risk of
triamcinolone) subjects, fluticasone propionate plasma development of systemic
concentrations increased significantly, corticosteroid effects, including
whereas the intrinsic cortisol levels Cushing’s syndrome and adrenal
decreased by approximately 86% (90% suppression.
CI 82-89%). Greater effects may be
expected when fluticasone is inhaled. Co-administration with CYP3A-
Systemic corticosteroid effects metabolised corticosteroids is not
including Cushing’s syndrome and recommended unless the potential
adrenal suppression have been reported benefit to the patient outweighs the
in patients receiving ritonavir and risk, in which case patients should
inhaled or intranasally administered be monitored for systemic
fluticasone. The effects of high corticosteroid effects.
fluticasone systemic exposure on
ritonavir plasma levels are unknown. Alternative corticosteroids which
are less dependent on CYP3A
Other corticosteroids: interaction not metabolism e.g. beclomethasone
studied. Plasma concentrations of these should be considered, particularly
medicinal products may be increased for long term use.
when co-administered with darunavir
with low dose ritonavir, resulting in
reduced serum cortisol concentrations.
Dexamethasone (systemic) Not studied. Dexamethasone may Systemic dexamethasone should be
decrease plasma concentrations of used with caution when combined
darunavir. (CYP3A induction) with darunavir co-administered with
low dose ritonavir.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 4d699252eaa8e454816efcf834725c875d4dc8037df504e7418d309238a96785 · Zeichen 43154–48076 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 59–60
HOS-134627 · Präparat HOS-097580
59
INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS
Medicinal products by Interaction Recommendations concerning co-
therapeutic areas Geometric mean change (%) administration
Perphenazine Not studied. Boosted darunavir is A dose decrease may be needed for
Risperidone expected to increase these these drugs when co-administered
Thioridazine antipsychotic plasma with boosted darunavir.
concentrations. (CYP3A, CYP2D6
and/or P-gp inhibition)
Lurasidone Concomitant administration of
Pimozide boosted darunavir and lurasidone,
Sertindole pimozide or sertindole is
contraindicated (see section 4.3).
β-BLOCKERS
Carvedilol Not studied. Boosted darunavir is Clinical monitoring is recommended
Metoprolol expected to increase these β-blocker when co-administering boosted
Timolol plasma concentrations. darunavir with β-blockers. A lower
(CYP2D6 inhibition) dose of the β-blocker should be
considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Not studied. Boosted darunavir can Clinical monitoring of therapeutic
Diltiazem be expected to increase the plasma and adverse effects is recommended
Felodipine concentrations of calcium channel when these medicines are
Nicardipine blockers. concomitantly administered with
Nifedipine (CYP3A and/or CYP2D6 boosted darunavir.
Verapamil inhibition)
CORTICOSTEROIDS
Corticosteroids primarily Fluticasone: in a clinical study Concomitant use of boosted
metabolised by CYP3A where ritonavir 100 mg capsules darunavir and corticosteroids (all
(including betamethasone, twice daily were co-administered routes of administration) that are
budesonide, fluticasone, with 50 μg intranasal fluticasone metabolised by CYP3A may increase
mometasone, prednisone, propionate (4 times daily) for 7 the risk of development of systemic
triamcinolone) days in healthy subjects, fluticasone corticosteroid effects, including
propionate plasma concentrations Cushing’s syndrome and adrenal
increased significantly, whereas the suppression.
intrinsic cortisol levels decreased
by approximately 86% (90% CI 82- Co-administration with CYP3A-
89%). Greater effects may be metabolised corticosteroids is not
expected when fluticasone is recommended unless the potential
inhaled. Systemic corticosteroid benefit to the patient outweighs the
effects including Cushing's risk, in which case patients should be
syndrome and adrenal suppression monitored for systemic corticosteroid
have been reported in patients effects.
receiving ritonavir and inhaled or
intranasally administered Alternative corticosteroids which are
fluticasone. The effects of high less dependent on CYP3A
fluticasone systemic exposure on metabolism
ritonavir plasma levels are e.g. beclomethasone should be
unknown. considered, particularly for long term
use.
Other corticosteroids: interaction
not studied. Plasma concentrations
of these medicinal products may be
increased when co-administered
with boosted darunavir, resulting in
reduced serum cortisol
concentrations.
Dexamethasone (systemic) Not studied. Dexamethasone may Systemic dexamethasone should be
decrease plasma concentrations of used with caution when combined
darunavir. with boosted darunavir.
(CYP3A induction)
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) propionate (HOS-108915) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 5be93392fc9daddc5a4bddcaf5177effda2055057fdf350b6c14c2d3c31e17fc · Zeichen 49576–54404 im Abschnitt
Wechselwirkungen · Symtuza
Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets Symtuza 675 mg/150 mg/200 mg/10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 14
HOS-138490 · Präparat HOS-098200
Lurasidone The combination of lurasidone,
Pimozide pimozide, quetiapine or sertindole
Quetiapine and Symtuza is contraindicated
Sertindole (see section 4.3).
β-BLOCKERS
Carvedilol Based on theoretical considerations Clinical monitoring is
Metoprolol DRV/COBI is expected to increase recommended when
Timolol these beta-blocker plasma co-administering Symtuza with
concentrations. beta-blockers and a lower dose of
(CYP2D6 inhibition) the beta-blocker should be
considered.
CALCIUM CHANNEL BLOCKERS
Amlodipine Based on theoretical considerations Clinical monitoring is
Diltiazem DRV/COBI is expected to increase recommended when these
Felodipine these calcium channel blocker medicinal products are
Nicardipine plasma concentrations. co-administered with Symtuza.
Nifedipine (CYP3A inhibition)
Verapamil
CORTICOSTEROIDS
Corticosteroids primarily Based on theoretical considerations Concomitant use of Symtuza and
metabolised by CYP3A DRV/COBI is expected to increase corticosteroids (all routes of
(including betamethasone, these corticosteroid plasma administration) that are
budesonide, fluticasone, concentrations. metabolised by CYP3A may
mometasone, prednisone, (CYP3A inhibition) increase the risk for development
triamcinolone) of systemic corticosteroid effects,
including Cushing’s syndrome
and adrenal suppression.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) carvedilol (HOS-115322) amlodipine (HOS-086287) calcium (HOS-085615) betamethasone (HOS-090066) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-09-16T11:21:00Z · SHA-256 542f840b29cc7afaff9940b20511550e8d35031b33d95efd774fd49f70f7819d · Passage 93d51832ca83543fafde6c13b4aad3650a78fd53d8dfafa10a844085355fa52e · Zeichen 24581–26821 im Abschnitt
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