Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.
Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
Mechanism unknown
Meperidine Tipranavir, co-administered with Dosage increase and long-term
No interaction study low dose ritonavir, is expected to use of meperidine with Aptivus,
performed decrease meperidine co-administered with low dose
concentrations and increase ritonavir, are not recommended
normeperidine metabolite due to the increased
concentrations. concentrations of the metabolite
normeperidine which has both
analgesic activity and CNS
stimulant activity (e.g. seizures).
Buprenorphine/Naloxone Buprenorphine ↔ Due to reduction in the levels of
the active metabolite
Norbuprenorphine AUC 79% norbuprenorphine, co-
Norbuprenorphine Cmax 80% administration of Aptivus, co-
Norbuprenorphine Cmin 80% administered with low dose
ritonavir, and
buprenorphine/naloxone may
result in decreased clinical
efficacy of buprenorphine.
Therefore, patients should be
monitored for opiate withdrawal
syndrome.
Immunosupressants
Cyclosporin Concentrations of cyclosporin, More frequent concentration
Tacrolimus tacrolimus, or sirolimus cannot monitoring of these medicinal
Sirolimus be predicted when co- products is recommended until
No interaction study administered with tipranavir co- blood levels have been stabilised.
performed administered with low dose
ritonavir, due to conflicting effect
of tipranavir, co-administered
with low dose ritonavir, on CYP
3A and P-gp.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Serotonergic interactions
The potential for serotonergic interactions has not been studied in either patients or healthy volunteers
(see sections 4.4 and 5.2). In Phase 3 studies, subjects taking serotonergic agents including
antidepressants such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and
serotonin 5-hydroxytryptamine (5-HT1) receptor agonists (triptans), meperidine, or buspirone were
excluded.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Serotonergic interactions
The potential for serotonergic interactions has not been studied in either patients or healthy volunteers
(see sections 4.4 and 5.2). In Phase 3 studies, subjects taking serotonergic agents including
antidepressants such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and
serotonin 5-hydroxytryptamine (5-HT1) receptor agonists (triptans), meperidine, or buspirone were
excluded.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Serotonergic interactions
The potential for serotonergic interactions has not been studied in either patients or healthy volunteers
(see sections 4.4 and 5.2). In Phase 3 studies, subjects taking serotonergic agents including
antidepressants such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and
serotonin 5-hydroxytryptamine (5-HT1) receptor agonists (triptans), meperidine, or buspirone were
excluded.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Version 2026-09-08T12:22:00Z · SHA-256 67755293d17b65838d18c0065efbf6826bb5cdd2698a851f617dd402e701dbd8 · Passage c5c71a9c63b64202ec2d2a9511db971cde40e1a8689b51e89de9169409117259 · Zeichen 925–1362 im Abschnitt
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