Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.
Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
Alcohol should not be taken with Circadin, because it reduces the effectiveness of
Circadin on sleep.
Circadin may enhance the sedative properties of benzodiazepines and
non-benzodiazepine hypnotics, such as zaleplon, zolpidem and zopiclone. In a clinical
trial, there was clear evidence for a transitory pharmacodynamic interaction between
Circadin and zolpidem one hour following co-dosing. Concomitant administration
resulted in increased impairment of attention, memory and co-ordination compared to
zolpidem alone.
Circadin has been co-administered in studies with thioridazine and imipramine, active
substances which affect the central nervous system. No clinically significant
pharmacokinetic interactions were found in each case. However, Circadin
co-administration resulted in increased feelings of tranquility and difficulty in
performing tasks compared to imipramine alone, and increased feelings of “muzzy-
headedness” compared to thioridazine alone.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
4
Benzodiazepines/non-benzodiazepine hypnotics
Melatonin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics,
such as zaleplon, zolpidem and zopiclone. In a clinical trial, there was clear evidence for a transitory
pharmacodynamic interaction between melatonin and zolpidem one hour following co-dosing.
Concomitant administration resulted in increased impairment of attention, memory and co-ordination
compared to zolpidem alone. Combination with benzodiazepines and non-benzodiazepine hypnotics
should be avoided.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Version 2026-06-10T15:35:00Z · SHA-256 17494391b1b166184a1056469270f628e4597dda5631ec4cd470a78d59405d08 · Passage 4030e09921f15cfc2b565686662ef4ed7fd3acf8b7b6bbc320473c2dbdac1552 · Zeichen 898–1450 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.