Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Lojuxta

Lojuxta 2 mg hard capsules Lojuxta 5 mg hard capsules Lojuxta 10 mg hard capsules Lojuxta 20 mg hard capsules · Abschnitt 4.5 · PDF-Seite 11

HOS-127355 · Präparat HOS-096397

Weak CYP3A4 inhibitors are When administered with atorvastatin, the expected to increase the exposure of dose of lomitapide should either be taken lomitapide when taken 12 hours apart or be decreased by half (see simultaneously. section 4.2). The dose of lomitapide should be taken 12 hours apart from any other When lomitapide 20 mg was concomitant weak CYP3A4 inhibitors. co-administered simultaneously with Examples of weak CYP3A4 inhibitors atorvastatin, a weak CYP3A4 include: alprazolam, amiodarone, inhibitor, lomitapide AUC and Cmax amlodipine, atorvastatin, azithromycin, increased approximately 2-fold. bicalutamide, cilostazol, cimetidine, When the dose of lomitapide was ciclosporin, clotrimazole, fluoxetine, taken 12 hours apart from fluvoxamine, fosaprepitant, ginkgo, atorvastatin, no clinically meaningful goldenseal, isoniazid, ivacaftor, lacidipine, increase in lomitapide exposure was lapatinib, linagliptin, nilotinib, observed. oestrogen-containing oral contraceptives, pazopanib, peppermint oil, propiverine, When lomitapide 20 mg was co- ranitidine, ranolazine, roxithromycin, Seville administered simultaneously or oranges, tacrolimus, ticagrelor and tolvaptan. 12 hours apart with ethinyl This list is not intended to be comprehensive estradiol/norgestimate, a weak and prescribers should check the prescribing CYP3A4 inhibitor, no clinically information of medicinal products to be co- meaningful increase in lomitapide administered with Lojuxta for potential exposure was observed. CYP3A4 mediated interactions.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ticagrelor (HOS-112065) lacidipine (HOS-113865) norgestimate (HOS-110544) cilostazol (HOS-111550) cimetidine (HOS-085835) atorvastatin (HOS-086304) alprazolam (HOS-086171) roxithromycin (HOS-127365) propiverine (HOS-127363) peppermint oil (HOS-127362) estradiol (HOS-090751) amlodipine (HOS-086287) azithromycin (HOS-088112) clotrimazole (HOS-090574) bicalutamide (HOS-127356) tolvaptan (HOS-109429) fosaprepitant (HOS-117427) lapatinib (HOS-122565) ivacaftor (HOS-109475) tacrolimus (HOS-085202) linagliptin (HOS-124309) pazopanib (HOS-122551) fluoxetine (HOS-085946) ranitidine (HOS-085660) amiodarone (HOS-085596) fluvoxamine (HOS-085908) ranolazine (HOS-086141) isoniazid (HOS-088590) nilotinib (HOS-086218)