Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
Clopidogrel/Acetylsalicylic acid Zentiva 75 mg/75 mg film-coated tablets Clopidogrel/Acetylsalicylic acid Zentiva 75 mg/100 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 10
HOS-212270 · Präparat HOS-154856
In CURE there was no excess in major bleeds with clopidogrel plus ASA within 7 days after coronary
bypass graft surgery in patients who stopped therapy more than five days prior to surgery. In patients
who remained on therapy within five days of bypass graft surgery, the event rate was 9.6% for
clopidogrel plus ASA, and 6.3% for placebo plus ASA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage 4e2c522d5dcdb317af183781465bac3785668640c11d1612f98b64e01c8cbb46 · Zeichen 1079–1427 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212271 · Präparat HOS-154856
In CLARITY, there was an overall increase in bleeding in the clopidogrel plus ASA group vs. the
group taking ASA alone. The incidence of major bleeding was similar between groups. This was
consistent across subgroups of patients defined by baseline characteristics, and type of fibrinolytic or
heparin therapy.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage a981bf0b1072329ff45e1734b85cc502c19a1f0ea7fc35512fc1088f625ea73d · Zeichen 1429–1739 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212272 · Präparat HOS-154856
In COMMIT, the overall rate of noncerebral major bleeding or cerebral bleeding was low and similar
in both groups.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage fb25c7a56f05c053153f9ffb2ffcc09a6f15724564eeed74be86a5f4a7c22769 · Zeichen 1741–1855 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212273 · Präparat HOS-154856
Tabulated list of adverse reactions
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage d51c90b617391dca447a849e03c6ddac1785fb6a36da5cf3e36f8f60e5aed8a9 · Zeichen 1857–1892 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212274 · Präparat HOS-154856
Adverse reactions that occurred with clopidogrel alone, with ASA alone or with clopidogrel in
combination with ASA either during clinical studies or that were spontaneously reported are presented
in the table below. Their frequency is defined using the following conventions: common (≥1/100 to
<1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not
known (cannot be estimated from the available data). Within each system organ class, adverse
reactions are presented in order of decreasing seriousness.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage fbfbb7190421d56bf137871a0ad114613cf86ef17864aa848fdf60d1420c6dd0 · Zeichen 1894–2436 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212275 · Präparat HOS-154856
10
System organ Common Uncommon Rare Very rare, not known
class
Blood and the Thrombocytopenia, Neutropenia, Thrombotic
lymphatic system leucopenia, including thrombocytopenic
disorders eosinophilia severe purpura (TTP) (see
neutropenia section 4.4), bone
marrow failure*,
aplastic anaemia,
pancytopenia,
bicytopenia*,
agranulocytosis, severe
thrombocytopenia,
acquired haemophilia
A, granulocytopenia,
anaemia, haemolytic
anaemia in patients
with
glucose-6-phosphate
dehydrogenase (G6PD)
deficiency* (see
section 4.4)
Cardiac disorders Kounis syndrome
(vasospastic allergic
angina / allergic
myocardial infarction)
in the context of a
hypersensitivity
reaction due to
acetylsalicylic acid* or
clopidogrel**
Immune system Anaphylactic shock*,
disorders serum sickness,
anaphylactoid
reactions,
cross-reactive drug
hypersensitivity among
thienopyridines (such
as ticlopidine,
prasugrel) (see section
4.4)**,insulin
autoimmune
syndrome, which can
lead to severe
hypoglycemia,
particularly in patients
with HLA DRA4
subtype (more frequent
in the Japanese
population)**,
aggravation of allergic
symptoms of food
allergy*
Metabolism and Hypoglycaemia*,
nutrition disorders gout* (see section 4.4)
Psychiatric Hallucinations,
disorders confusion
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage c0b9a8c68931873391ef0147b93cbb91bd89e8fc5639de2b5e71546e23a5ee81 · Zeichen 2492–7000 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212276 · Präparat HOS-154856
11
System organ Common Uncommon Rare Very rare, not known
class
Nervous system Intracranial Taste disturbances,
disorders bleeding (some ageusia
cases were
reported with fatal
outcome,
especially in
elderly), headache,
paraesthesia,
dizziness
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage a61d8fa1b39f035b274ceb5e0b688d536a7f30630ccf8fb71b3d0ec28fc87b8c · Zeichen 7042–7634 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212277 · Präparat HOS-154856
Eye disorders Eye bleeding
(conjunctival,
ocular, retinal)
Ear and labyrinth Vertigo Hearing loss* or
disorders tinnitus*
Vascular disorders Haematoma Serious haemorrhage,
haemorrhage of
operative wound,
vasculitis (including
Henoch-Schönlein
purpura*), hypotension
Respiratory, Epistaxis Respiratory tract
thoracic and bleeding (haemoptysis,
mediastinal pulmonary
disorders haemorrhage),
bronchospasm,
interstitial
pneumonitis,
non-cardiogenic
pulmonary edema with
chronic use and in the
context of a
hypersensitivity
reaction due to
acetylsalicylic acid*,
eosinophilic
pneumonia.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage 95e2aad75c1ee09f03468110156d808963a0a1a6c36bbd02b7dc2f2d068f986d · Zeichen 7636–9763 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212278 · Präparat HOS-154856
12
System organ Common Uncommon Rare Very rare, not known
class
Gastrointestinal Gastrointestinal Gastric ulcer and Retroperitoneal Gastrointestinal and
disorders haemorrhage, duodenal ulcer, haemorrhage retroperitoneal
diarrhoea, gastritis, vomiting, haemorrhage with fatal
abdominal nausea, outcome, pancreatitis.
pain, dyspepsia constipation, Upper gastrointestinal
flatulence disorders
(oesophagitis,
oesophageal
ulceration, perforation,
erosive gastritis,
erosive duodenitis;
gastro-duodenal
ulcer/perforations)*;
lower gastrointestinal
disorders (small
[jejunum and ileum]
and large [colon and
rectum] intestinal
ulcers, colitis and
intestinal
perforation)*; upper
gastro-intestinal
symptoms* such as
gastralgia (see section
4.4); these ASA-
related GI reactions
may or may not be
associated with
haemorrhage, and may
occur at any dose of
acetylsalicylic acid and
in patients with or
without warning
symptoms or a
previous history of
serious GI events*.
Colitis (including
ulcerative or
lymphocytic colitis),
stomatitis, acute
pancreatitis in the
context of a
hypersensitivity
reaction due to
acetylsalicylic acid*
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage 224719a03a90a8598b9140aa23d6f3db15641833684609cb879b2aa6a6dd5278 · Zeichen 9812–14239 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212279 · Präparat HOS-154856
13
System organ Common Uncommon Rare Very rare, not known
class
Hepatobiliary Acute liver failure,
disorders liver injury, mainly
hepatocellular*,
hepatitis, elevation of
hepatic enzymes*,
abnormal liver
function test, chronic
hepatitis*
Skin and Bruising Rash, pruritus, skin Bullous dermatitis
subcutaneous tissue bleeding (purpura) (toxic epidermal
disorders necrolysis, Stevens
Johnson Syndrome,
erythema multiforme,
acute generalised
exanthematous
pustulosis (AGEP)),
angioedema,
drug-induced
hypersensitivity
syndrome, drug rash
with eosinophilia and
systemic symptoms
(DRESS), rash
erythematous or
exfoliative, urticaria,
eczema, lichen planus,
fixed eruption*
Reproductive Gynaecomastia
systems and breast
disorders
Musculoskeletal Musculo-skeletal
and connective bleeding
tissue disorders (haemarthrosis),
arthritis, arthralgia,
myalgia
Renal and urinary Haematuria Renal failure*, acute
disorders renal impairment
(especially in patients
with existing renal
impairment, heart
decompensation,
nephritic syndrome, or
concomitant treatment
with diuretics)*,
glomerulonephritis,
blood creatinine
increased
General disorders Bleeding at the Fever, edema*
and administration puncture site
site conditions
Investigations Bleeding time
prolonged,
neutrophil count
decreased, platelet
count decreased
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage 940205c36d945767b49529ad76db79fea34b5ad0f3d88cdff25edc61a71bbdeb · Zeichen 14292–19153 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212280 · Präparat HOS-154856
14
* Information reported in published information for ASA with frequency “not known”.
** Information related to clopidogrel with frequency “not known”.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
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Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage e672fb0c7f8d62a50a3cfbdfa3d73732d33e6da4edae688cf3295397f13bbc55 · Zeichen 19204–19357 im Abschnitt
Nebenwirkungen · Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover)
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HOS-212281 · Präparat HOS-154856
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It
allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare
professionals are asked to report any suspected adverse reactions via the national reporting system
listed in Appendix V.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
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Version 2019-11-13T14:36:00Z · SHA-256 fdf7b1939833e55bbc6a1c8732c66c147ac4404b0347a1c2e50406556ee7b8c0 · Passage 42f7144177697b690f59b1bda795c3fd216297691cf296a2e1269a137feab3cd · Zeichen 19359–19714 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.