Wirkstoffe & Arzneimittelsicherheit

Gegenanzeigen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.3 · PDF-Seite 6

HOS-147286 · Präparat HOS-099634

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Gegenanzeigen · Wegovy

Wegovy 1.5 mg tablets Wegovy 4 mg tablets Wegovy 9 mg tablets Wegovy 25 mg tablets · Abschnitt 4.3 · PDF-Seite 42

HOS-147338 · Präparat HOS-099634

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8

HOS-147287 · Präparat HOS-099634

Semaglutide delays gastric emptying and could potentially influence the absorption of concomitantly administered oral medicinal products. No clinically relevant effect on the rate of gastric emptying was observed with semaglutide 2.4 mg, probably due to a tolerance effect. The effect of semaglutide 7.2 mg on the rate of gastric emptying has not been investigated. Semaglutide should be used with caution in patients receiving oral medicinal products that require rapid gastrointestinal absorption.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8

HOS-147288 · Präparat HOS-099634

Paracetamol

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8

HOS-147289 · Präparat HOS-099634

Semaglutide delays the rate of gastric emptying as assessed by paracetamol pharmacokinetics during a standardised meal test. Paracetamol AUC0-60min and Cmax were decreased by 27% and 23%, respectively, following concomitant use of semaglutide 1 mg. The total paracetamol exposure (AUC0-5h) was not affected. No clinically relevant effect on paracetamol was observed with semaglutide. No dose adjustment of paracetamol is necessary when administered with semaglutide.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8

HOS-147290 · Präparat HOS-099634

Oral contraceptives

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8

HOS-147291 · Präparat HOS-099634

Semaglutide is not anticipated to decrease the effectiveness of oral contraceptives. It did not change the overall exposure of ethinylestradiol and levonorgestrel to a clinically relevant degree, when an oral contraceptive combination medicinal product (0.03 mg ethinylestradiol/0.15 mg levonorgestrel) was co-administered with semaglutide. Exposure of ethinylestradiol was not affected; an increase of 20% was observed for levonorgestrel exposure at steady state. Cmax was not affected for any of the compounds.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): levonorgestrel (HOS-089677)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 8–9

HOS-147293 · Präparat HOS-099634

8 Atorvastatin

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): atorvastatin (HOS-086304)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147294 · Präparat HOS-099634

Semaglutide did not change the overall exposure of atorvastatin following a single dose administration of atorvastatin (40 mg). Atorvastatin Cmax was decreased by 38%. This was assessed not to be clinically relevant.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): atorvastatin (HOS-086304)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147295 · Präparat HOS-099634

Semaglutide did not change the overall exposure or Cmax of digoxin following a single dose of digoxin (0.5 mg).

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): digoxin (HOS-086172)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147296 · Präparat HOS-099634

Metformin

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): metformin (HOS-091032)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147298 · Präparat HOS-099634

Semaglutide did not change the overall exposure or Cmax of metformin following dosing of 500 mg twice daily over 3.5 days.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): metformin (HOS-091032)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147299 · Präparat HOS-099634

Warfarin and other coumarin derivatives

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): coumarin (HOS-088372) warfarin (HOS-085950)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147301 · Präparat HOS-099634

Semaglutide did not change overall exposure or Cmax of R- and S-warfarin following a single dose of warfarin (25 mg), and the pharmacodynamic effects of warfarin as measured by the international normalised ratio (INR) were not affected in a clinically relevant manner. However, cases of decreased INR have been reported during concomitant use of acenocoumarol and semaglutide. Upon initiation of semaglutide treatment in patients on warfarin or other coumarin derivatives, frequent monitoring of INR is recommended.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): coumarin (HOS-088372) acenocoumarol (HOS-109456) warfarin (HOS-085950)

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147303 · Präparat HOS-099634

Paediatric population

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.5 · PDF-Seite 9

HOS-147304 · Präparat HOS-099634

Interaction studies have only been performed in adults.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 1.5 mg tablets Wegovy 4 mg tablets Wegovy 9 mg tablets Wegovy 25 mg tablets · Abschnitt 4.5 · PDF-Seite 44

HOS-147339 · Präparat HOS-099634

Semaglutide delays gastric emptying which may influence the absorption of other oral medicinal products.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 1.5 mg tablets Wegovy 4 mg tablets Wegovy 9 mg tablets Wegovy 25 mg tablets · Abschnitt 4.5 · PDF-Seite 44

HOS-147340 · Präparat HOS-099634

Effects of semaglutide on other medicinal products

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

Wechselwirkungen · Wegovy

Wegovy 1.5 mg tablets Wegovy 4 mg tablets Wegovy 9 mg tablets Wegovy 25 mg tablets · Abschnitt 4.5 · PDF-Seite 44

HOS-147341 · Präparat HOS-099634

Thyroxine Total exposure (Area Under the Curve (AUC)) of thyroxine (adjusted for endogenous levels) was increased by 33% following administration of a single dose of levothyroxine. Maximum exposure (Cmax) was unchanged. Monitoring of thyroid parameters should be considered when treating patients with semaglutide at the same time as levothyroxine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): levothyroxine (HOS-086339)

Wechselwirkungen · Wegovy

Wegovy 1.5 mg tablets Wegovy 4 mg tablets Wegovy 9 mg tablets Wegovy 25 mg tablets · Abschnitt 4.5 · PDF-Seite 44

HOS-147342 · Präparat HOS-099634

Warfarin and other coumarin derivatives Semaglutide did not change the AUC or Cmax of R- and S-warfarin following a single dose of warfarin, and the pharmacodynamic effects of warfarin as measured by the international normalised ratio (INR) were not affected in a clinically relevant manner. However, cases of decreased INR have been reported during concomitant use of acenocoumarol and semaglutide. Upon initiation of semaglutide treatment in patients on warfarin or other coumarin derivatives, frequent monitoring of INR is recommended.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): coumarin (HOS-088372) acenocoumarol (HOS-109456) warfarin (HOS-085950)