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Krazati · 4.3 · Concomitant use of CYP3A substrates with a narrow therapeutic index (see sections 4.4 and 4.5).
Eintrag öffnenKrazati · 4.5 · Breast cancer resistance protein (BCRP) or organic anion-transporting polypeptides 1B1 (OATP1B1) substrates No
Eintrag öffnenKrazati · 4.5 · CYP2C9 substrates: In vitro, adagrasib inhibits CYP2C9. Avoid concomitant use of adagrasib with sensitive CYP2
Eintrag öffnenKrazati · 4.5 · CYP2D6 substrates: Co-administration of dextromethorphan (a sensitive CYP2D6 substrate) with multiple doses of
Eintrag öffnenKrazati · 4.5 · P-glycoprotein (P-gp) substrates Administration of adagrasib 600 mg single dose increased digoxin (a P-gp subs
Eintrag öffnenKrazati · 4.5 · Substrates of cytochrome P450 (CYP) enzymes CYP3A4 substrates: Co-administration of oral midazolam (a sensitiv
Eintrag öffnenLaventair Ellipta (previously Laventair) · 4.5 · Both umeclidinium and vilanterol are substrates of the P-glycoprotein transporter (P-gp). The effect of the mo
Eintrag öffnenLazcluze · 4.5 · BCRP substrates
Eintrag öffnenLazcluze · 4.5 · CYP1A2 substrates
Eintrag öffnenLazcluze · 4.5 · CYP3A4 substrates
Eintrag öffnenLazcluze · 4.5 · Induction of CYP1A2 cannot be excluded. Therefore, caution is advised when co-administering with substrates of
Eintrag öffnenLeflunomide Zentiva (previously Leflunomide Winthrop) · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide Zentiva (previously Leflunomide Winthrop) · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide Zentiva (previously Leflunomide Winthrop) · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide medac · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLixiana · 4.5 · P-gp substrates
Eintrag öffnenLojuxta · 4.5 · P-glycoprotein (P-gp) substrates Lomitapide inhibits P-gp in vitro, and may increase the absorption of P-gp su
Eintrag öffnenLonsurf · 4.5 · Caution is required when using medicinal products that are human thymidine kinase substrates, e.g., zidovudine
Eintrag öffnenLorviqua · 4.5 · CYP2B6 substrates
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