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Janumet · 4.5 · In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transpo
Eintrag öffnenJanuvia · 4.5 · In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transpo
Eintrag öffnenJascayd · 4.5 · Based on in vitro assessment, nerandomilast is mainly metabolised by CYP3A and is a substrate of P-glycoprotei
Eintrag öffnenJavlor · 4.5 · A possible interaction with paclitaxel and docetaxel (CYP3 substrates) has been suggested from an in vitro stu
Eintrag öffnenJavlor · 4.5 · In vitro studies showed that vinflunine is a Pgp-substrate like other vinca alkaloids, but with a lower affini
Eintrag öffnenJaypirca · 4.5 · 5 P-gp substrates Pirtobrutinib is a weak inhibitor of P-gp. Pirtobrutinib increased the AUC and Cmax of digox
Eintrag öffnenJaypirca · 4.5 · BCRP substrates Pirtobrutinib is a moderate inhibitor of BCRP. Pirtobrutinib increased the AUC and Cmax of ros
Eintrag öffnenJaypirca · 4.5 · CYP2C19 substrates Pirtobrutinib is a weak inhibitor of CYP2C19. Pirtobrutinib increased the AUC and Cmax of o
Eintrag öffnenJaypirca · 4.5 · CYP2C8 substrates Pirtobrutinib is a moderate inhibitor of CYP2C8. Pirtobrutinib increased the AUC and Cmax of
Eintrag öffnenJaypirca · 4.5 · CYP3A substrates Pirtobrutinib is a weak inhibitor of CYP3A. Pirtobrutinib increased the AUC and Cmax of orall
Eintrag öffnenJemperli · 4.5 · No interaction studies have been performed. Monoclonal antibodies (mAb) such as dostarlimab are not substrates
Eintrag öffnenJentadueto · 4.5 · 7 Organic cation transporters (OCT) Metformin is a substrate of both transporters OCT1 and OCT2. Co-administra
Eintrag öffnenJentadueto · 4.5 · Linagliptin is a P-glycoprotein substrate, and inhibits P-glycoprotein mediated transport of digoxin with low
Eintrag öffnenJinarc · 4.5 · 8 Transporter substrates P-glycoprotein substrates: In-vitro studies indicate that tolvaptan is a substrate an
Eintrag öffnenJinarc · 4.5 · CYP3A substrates In healthy subjects, tolvaptan, a CYP3A substrate, had no effect on the plasma concentrations
Eintrag öffnenJoenja · 4.5 · BCRP inhibitors Leniolisib is a substrate of BCRP transporters. No interaction studies have been conducted wit
Eintrag öffnenJoenja · 4.5 · OAT3 substrates Leniolisib is an OAT3 inhibitor and may increase systemic exposure to OAT3 substrates (e.g., a
Eintrag öffnenJoenja · 4.5 · OATP1B1, OATP1B3, and BCRP substrates When co-administered, leniolisib increased rosuvastatin exposure 2-fold.
Eintrag öffnenJoenja · 4.5 · UDP-glucuronosyltransferase (UGT) 1A1 substrates In vitro, leniolisib is an inhibitor of UGT1A1, and although
Eintrag öffnenKaftrio · 4.5 · 9 In vitro studies showed that TEZ is a substrate for the uptake transporter OATP1B1 and efflux transporters P
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