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Kaftrio · 4.5 · CYP2C9 substrates IVA may inhibit CYP2C9; therefore, monitoring of the international normalised ratio (INR) du
Eintrag öffnenKaftrio · 4.5 · CYP2C9 substrates IVA may inhibit CYP2C9; therefore, monitoring of the international normalised ratio (INR) du
Eintrag öffnenKaftrio · 4.5 · CYP3A inducers ELX, TEZ and IVA are substrates of CYP3A (IVA is a sensitive substrate of CYP3A). Concomitant u
Eintrag öffnenKaftrio · 4.5 · CYP3A inducers ELX, TEZ and IVA are substrates of CYP3A (IVA is a sensitive substrate of CYP3A). Concomitant u
Eintrag öffnenKaftrio · 4.5 · In vitro studies showed that IVA is not a substrate for OATP1B1, OATP1B3, or P-gp. IVA and its metabolites are
Eintrag öffnenKaftrio · 4.5 · In vitro studies showed that IVA is not a substrate for OATP1B1, OATP1B3, or P-gp. IVA and its metabolites are
Eintrag öffnenKaftrio · 4.5 · In vitro studies showed that TEZ is a substrate for the uptake transporter OATP1B1 and efflux transporters P-g
Eintrag öffnenKaftrio · 4.5 · Potential for interaction with transporters In vitro studies showed that ELX is a substrate for the efflux tra
Eintrag öffnenKaftrio · 4.5 · Potential for interaction with transporters In vitro studies showed that ELX is a substrate for the efflux tra
Eintrag öffnenKalydeco · 4.5 · 41 CYP2C9 substrates
Eintrag öffnenKalydeco · 4.5 · Administration of ivacaftor may increase systemic exposure of medicinal products that are sensitive substrates
Eintrag öffnenKalydeco · 4.5 · Administration of ivacaftor may increase systemic exposure of medicinal products that are sensitive substrates
Eintrag öffnenKalydeco · 4.5 · CYP2C9 substrates
Eintrag öffnenKalydeco · 4.5 · CYP3A substrates
Eintrag öffnenKalydeco · 4.5 · CYP3A substrates
Eintrag öffnenKalydeco · 4.5 · Co-administration with (oral) midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, c
Eintrag öffnenKalydeco · 4.5 · Co-administration with (oral) midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, c
Eintrag öffnenKalydeco · 4.5 · Co-administration with digoxin, a sensitive P-gp substrate, increased digoxin exposure by 1.3-fold, consistent
Eintrag öffnenKalydeco · 4.5 · Co-administration with digoxin, a sensitive P-gp substrate, increased digoxin exposure by 1.3-fold, consistent
Eintrag öffnenKalydeco · 4.5 · Digoxin and other P-gp substrates
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