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Kalydeco · 4.5 · Digoxin and other P-gp substrates
Eintrag öffnenKalydeco · 4.5 · In vitro studies showed that ivacaftor is not a substrate for OATP1B1 or OATP1B3. Ivacaftor and its metabolite
Eintrag öffnenKalydeco · 4.5 · In vitro studies showed that ivacaftor is not a substrate for OATP1B1 or OATP1B3. Ivacaftor and its metabolite
Eintrag öffnenKalydeco · 4.5 · Ivacaftor is a sensitive CYP3A substrate. Co-administration with ketoconazole, a strong CYP3A inhibitor, incre
Eintrag öffnenKalydeco · 4.5 · Ivacaftor is a sensitive CYP3A substrate. Co-administration with ketoconazole, a strong CYP3A inhibitor, incre
Eintrag öffnenKalydeco · 4.5 · Ivacaftor is a substrate of CYP3A4 and CYP3A5. It is a weak inhibitor of CYP3A and P-glycoprotein (P-gp) and a
Eintrag öffnenKalydeco · 4.5 · Ivacaftor is a substrate of CYP3A4 and CYP3A5. It is a weak inhibitor of CYP3A and P-glycoprotein (P-gp) and a
Eintrag öffnenKerendia · 4.5 · Effect of 40 mg finerenone on CYP3A4 and CYP2C8 substrates At 40 mg once daily, finerenone is a weak inhibitor
Eintrag öffnenKetoconazole Esteve (previously Ketoconazole HRA) · 4.5 · 14 * Rosuvastatin is not a CYP 3A4 substrate. Ketoconazole did not produce any change in rosuvastatin pharmaco
Eintrag öffnenKevzara · 4.5 · Caution should be exercised in patients who start sarilumab treatment while on therapy with CYP3A4 substrates
Eintrag öffnenKevzara · 4.5 · Caution should be exercised in patients who start sarilumab treatment while on therapy with CYP3A4 substrates
Eintrag öffnenKevzara · 4.5 · The modulation of IL-6 effect on CYP enzymes by sarilumab may be clinically relevant for CYP substrates with a
Eintrag öffnenKevzara · 4.5 · The modulation of IL-6 effect on CYP enzymes by sarilumab may be clinically relevant for CYP substrates with a
Eintrag öffnenKineret · 4.5 · Cytochrome P450 Substrates The formation of CYP450 enzymes is suppressed by increased levels of cytokines (e.g
Eintrag öffnenKisplyx · 4.5 · CYP3A4 substrates
Eintrag öffnenKisqali · 4.5 · Co-administration of caffeine (CYP1A2 substrate) with multiple doses of Kisqali (400 mg) increased the caffein
Eintrag öffnenKisqali · 4.5 · Co-administration of midazolam (CYP3A4 substrate) with multiple doses of Kisqali (400 mg) increased the midazo
Eintrag öffnenKisqali · 4.5 · Concomitant administration of ribociclib with the following CYP3A4 substrates should be avoided: alfuzosin, am
Eintrag öffnenKisqali · 4.5 · Ribociclib is a moderate to strong CYP3A4 inhibitor and may interact with medicinal substrates that are metabo
Eintrag öffnenKisqali · 4.5 · Substances that are substrates of transporters
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