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Adempas · 4.5 · Co-administration of the antacid aluminium hydroxide / magnesium hydroxide reduced riociguat mean AUC by 34% a
Eintrag öffnenAdempas · 4.5 · Concomitant use with CYP1A1, UGT1A1 and UGT1A9 inhibitors From the recombinant CYP isoforms investigated in vi
Eintrag öffnenAdempas · 4.5 · Concomitant use with CYP1A1, UGT1A1 and UGT1A9 inhibitors From the recombinant CYP isoforms investigated in vi
Eintrag öffnenAdempas · 4.5 · Concomitant use with CYP3A4 inducers Bosentan, reported to be a moderate inducer of CYP3A4, led to a decrease
Eintrag öffnenAdempas · 4.5 · Concomitant use with CYP3A4 inducers Bosentan, reported to be a moderate inducer of CYP3A4, led to a decrease
Eintrag öffnenAdempas · 4.5 · Concomitant use with medicinal products increasing gastric pH Riociguat exhibits a reduced solubility at neutr
Eintrag öffnenAdempas · 4.5 · Concomitant use with medicinal products increasing gastric pH Riociguat exhibits a reduced solubility at neutr
Eintrag öffnenAdempas · 4.5 · Concomitant use with other CYP and P-gp/BCRP inhibitors Medicinal products strongly inhibiting P-gp/BCRP such
Eintrag öffnenAdempas · 4.5 · Concomitant use with other CYP and P-gp/BCRP inhibitors Medicinal products strongly inhibiting P-gp/BCRP such
Eintrag öffnenAdempas · 4.5 · Concomitant use with strong multi pathway CYP and P-gp/BCRP inhibitors The concomitant use of riociguat with s
Eintrag öffnenAdempas · 4.5 · Effects of other substances on riociguat
Eintrag öffnenAdempas · 4.5 · Effects of other substances on riociguat
Eintrag öffnenAdempas · 4.5 · Effects of riociguat on other substances
Eintrag öffnenAdempas · 4.5 · Effects of riociguat on other substances
Eintrag öffnenAdempas · 4.5 · Interaction studies have been performed only in adults. Therefore, the absolute extent of interactions in the
Eintrag öffnenAdempas · 4.5 · Interaction studies have been performed only in adults. Therefore, the absolute extent of interactions in the
Eintrag öffnenAdempas · 4.5 · Nitrates In a clinical study the highest dose of riociguat (2.5 mg tablets 3 times daily) potentiated the bloo
Eintrag öffnenAdempas · 4.5 · Nitrates In a clinical study the highest dose of riociguat (2.5 mg tablets 3 times daily) potentiated the bloo
Eintrag öffnenAdempas · 4.5 · PDE5 inhibitors Preclinical studies in animal models showed additive systemic blood pressure lowering effect w
Eintrag öffnenAdempas · 4.5 · Patients must not get pregnant during riociguat therapy (see section 4.3). Riociguat (2.5 mg 3 times daily) di
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