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Apretude · 4.5 · Anticonvulsants Carbamazepine Cabotegravir Metabolic inducers may significantly decrease Oxcarbazepine cabot
Eintrag öffnenApretude · 4.5 · Based on the in vitro and clinical drug interaction profile, cabotegravir is not expected to alter concentrati
Eintrag öffnenApretude · 4.5 · Based on the in vitro and clinical drug interaction profile, cabotegravir is not expected to alter concentrati
Eintrag öffnenApretude · 4.5 · Cabotegravir is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), however, bec
Eintrag öffnenApretude · 4.5 · Cabotegravir is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), however, bec
Eintrag öffnenApretude · 4.5 · Cabotegravir is primarily metabolised by uridine diphosphate glucuronosyl transferase (UGT) 1A1 and to a lesse
Eintrag öffnenApretude · 4.5 · Cabotegravir is primarily metabolised by uridine diphosphate glucuronosyl transferase (UGT) 1A1 and to a lesse
Eintrag öffnenApretude · 4.5 · Effect of cabotegravir on the pharmacokinetics of other medicinal products
Eintrag öffnenApretude · 4.5 · Effect of cabotegravir on the pharmacokinetics of other medicinal products
Eintrag öffnenApretude · 4.5 · Effect of other agents on the pharmacokinetics of cabotegravir
Eintrag öffnenApretude · 4.5 · Effect of other medicinal products on the pharmacokinetics of cabotegravir
Eintrag öffnenApretude · 4.5 · In vitro cabotegravir inhibited organic anion transporters (OAT) 1 (IC50=0.81 µM) and OAT3 (IC50=0.41 µM). The
Eintrag öffnenApretude · 4.5 · In vitro, cabotegravir inhibited the organic anion transporters (OAT) 1 (IC50=0.81 µM) and OAT3 (IC50=0.41 µM)
Eintrag öffnenApretude · 4.5 · In vivo, cabotegravir did not have an effect on midazolam, a cytochrome P450 (CYP) 3A4 probe. In vitro, cabote
Eintrag öffnenApretude · 4.5 · In vivo, cabotegravir did not have an effect on midazolam, a cytochrome P450 (CYP) 3A4 probe. In vitro, cabote
Eintrag öffnenApretude · 4.5 · Medicinal products Interaction Recommendations concerning by therapeutic areas Geometric mean change (%) co-ad
Eintrag öffnenApretude · 4.5 · Medicinal products Interaction Recommendations concerning by therapeutic areas Geometric mean change (%) co-ad
Eintrag öffnenApretude · 4.5 · No drug interaction studies have been performed with cabotegravir injection. The drug interaction data provide
Eintrag öffnenApretude · 4.5 · Non-nucleoside Cabotegravir Rilpivirine did not significantly change Reverse Transcriptase AUC 12% caboteg
Eintrag öffnenApretude · 4.5 · Paediatric population Interaction studies have only been performed in adults
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