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Arsenic trioxide medac · 4.8 · Differentiation syndrome
Eintrag öffnenArsenic trioxide medac · 4.8 · During arsenic trioxide treatment, 14 of the 52 patients in the APL studies in the relapsed setting had one or
Eintrag öffnenArsenic trioxide medac · 4.8 · Haematological and gastrointestinal toxicity
Eintrag öffnenArsenic trioxide medac · 4.8 · In a phase 3, multicentre, noninferiority trial comparing ATRA plus chemotherapy with ATRA plus arsenic trioxi
Eintrag öffnenArsenic trioxide medac · 4.8 · In general, treatment-emergent adverse events tended to decrease over time, in relapsed/refractory APL patient
Eintrag öffnenArsenic trioxide medac · 4.8 · In newly diagnosed patients with low to intermediate risk APL 63.2 % developed grade 3 or 4 hepatic toxic effe
Eintrag öffnenArsenic trioxide medac · 4.8 · In newly diagnosed patients with low to intermediate risk APL, differentiation syndrome was observed in 19 % i
Eintrag öffnenArsenic trioxide medac · 4.8 · In newly diagnosed patients with low to intermediate risk APL, gastrointestinal toxicity, grade 3-4 neutropeni
Eintrag öffnenArsenic trioxide medac · 4.8 · In newly diagnosed patients, with low to intermediate risk APL, QTc prolongation was observed in 15.6 %. In on
Eintrag öffnenArsenic trioxide medac · 4.8 · In post-marketing experience, a differentiation syndrome, like retinoic acid syndrome, has also been reported
Eintrag öffnenArsenic trioxide medac · 4.8 · Mortality in the pivotal studies in the relapsed setting from disseminated intravascular coagulation (DIC) ass
Eintrag öffnenArsenic trioxide medac · 4.8 · Peripheral neuropathy
Eintrag öffnenArsenic trioxide medac · 4.8 · Peripheral neuropathy, characterised by paraesthesia/dysesthesia, is a common and well-known effect of environ
Eintrag öffnenArsenic trioxide medac · 4.8 · QT interval prolongation
Eintrag öffnenArsenic trioxide medac · 4.8 · Related adverse reactions of CTC grade 3 and 4 occurred in 37 % of relapsed/refractory APL patients in clinica
Eintrag öffnenArsenic trioxide medac · 4.8 · Reporting of suspected adverse reactions
Eintrag öffnenArsenic trioxide medac · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenArsenic trioxide medac · 4.8 · Serious adverse reactions were common (1-10 %) and not unexpected in the relapsed/refractory population. Those
Eintrag öffnenArsenic trioxide medac · 4.8 · Summary of the safety profile
Eintrag öffnenArsenic trioxide medac · 4.8 · Table 2 All grades Grades ≥ 3 Infections and infestations Herpes zoster Common Not known Sepsis Not known Not
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