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Avastin · 4.8 · 13 System organ Very common Common Uncommon Rare Very Frequency not class rare known
Eintrag öffnenAvastin · 4.8 · 14 Table 2 provides the frequency of severe adverse reactions. Severe reactions are defined as adverse events
Eintrag öffnenAvastin · 4.8 · 15 Uncommon (≥ 0.1% to < 1%) reports of fistulae that involve areas of the body other than the gastrointestina
Eintrag öffnenAvastin · 4.8 · 16 In patients developing PRES, early recognition of symptoms with prompt treatment of specific symptoms inclu
Eintrag öffnenAvastin · 4.8 · 17 The incidence of CNS bleeding in patients with untreated CNS metastases receiving bevacizumab has not been
Eintrag öffnenAvastin · 4.8 · 18 Patients who have experienced a venous thromboembolic reaction may be at higher risk for a recurrence if th
Eintrag öffnenAvastin · 4.8 · 19 Laboratory abnormalities Decreased neutrophil count, decreased white blood cell count and presence of urine
Eintrag öffnenAvastin · 4.8 · 20 Table 3 Adverse reactions reported in post-marketing setting
Eintrag öffnenAvastin · 4.8 · 21 professionals are asked to report any suspected adverse reactions via the national reporting system listed
Eintrag öffnenAvastin · 4.8 · Across all clinical trials, mucocutaneous haemorrhage has been seen in up to 50% of Avastin-treated patients.
Eintrag öffnenAvastin · 4.8 · Across clinical trials, 8 cases of PRES have been reported. Two of the eight cases did not have radiological c
Eintrag öffnenAvastin · 4.8 · Across clinical trials, the following Grade 3 and 4 (NCI-CTCAE v.3) laboratory abnormalities occurred in patie
Eintrag öffnenAvastin · 4.8 · Adverse reactions are added to the appropriate frequency category in the tables below according to the highest
Eintrag öffnenAvastin · 4.8 · An increased incidence of CHF has been observed in a clinical trial of patients with diffuse large B- cell lym
Eintrag öffnenAvastin · 4.8 · Arterial thromboembolism: An increased incidence of arterial thromboembolic reactions was observed in patients
Eintrag öffnenAvastin · 4.8 · Avastin is not approved for use in patients under the age of 18 years. In published literature reports, cases
Eintrag öffnenAvastin · 4.8 · Cases of non-mandibular osteonecrosis have been observed in Avastin treated paediatric patients (see section 4
Eintrag öffnenAvastin · 4.8 · Clinical trials have shown that transient increases in serum creatinine (ranging between 1.5-1.9 times baselin
Eintrag öffnenAvastin · 4.8 · Congenital, Foetal familial, and abnormalitiesa,b genetic disorder General Asthenia, Lethargy disorders and Fa
Eintrag öffnenAvastin · 4.8 · Congenital, familial, Cases of foetal abnormalities in women treated with bevacizumab and genetic disorder alo
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