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Bosulif · 4.5 · In a study of 24 healthy subjects in whom 5 daily doses of 400 mg ketoconazole (a strong CYP3A inhibitor) were
Eintrag öffnenBosulif · 4.5 · In a study of 27 healthy subjects, in whom a single dose of 500 mg bosutinib was co-administered with a single
Eintrag öffnenBosulif · 4.5 · In vitro studies indicate that bosutinib has a low potential to inhibit breast cancer resistance protein (BCRP
Eintrag öffnenBosulif · 4.5 · In vitro studies indicate that clinical drug-drug interactions are unlikely to occur at therapeutic doses as a
Eintrag öffnenBosulif · 4.5 · Proton pump inhibitors (PPIs) Caution should be exercised when administering bosutinib concomitantly with PPIs
Eintrag öffnenBosulif · 4.5 · Selection of an alternate concomitant medicinal product with no or minimal CYP3A enzyme inhibition potential,
Eintrag öffnenBosulif · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenBosulif · 4.8 Undesirable effects · 1
Eintrag öffnenBosulif · 4.8 · **Adverse reaction identified post marketing in adults.
Eintrag öffnenBosulif · 4.8 · 12 Tabulated list of adverse reactions
Eintrag öffnenBosulif · 4.8 · 13 Gastrointestinal disorders Very common Diarrhoea Nausea Abdominal paino Vomiting Common Gastritis Gastroint
Eintrag öffnenBosulif · 4.8 · 14 h Hypophosphataemia includes Blood phosphorus decreased, Hypophosphataemia i Hyperkalaemia includes Blood p
Eintrag öffnenBosulif · 4.8 · 15 Blood and lymphatic events in 55 paediatric patients in the BCHILD study include thrombocytopenia in 19 (34
Eintrag öffnenBosulif · 4.8 · 16 Hepatobiliary disorders Among adult patients with reports of adverse reactions of elevations in either ALT
Eintrag öffnenBosulif · 4.8 · 17 professionals are asked to report any suspected adverse reactions via the national reporting system listed
Eintrag öffnenBosulif · 4.8 · A total of 1 372 leukaemia adult patients received at least 1 dose of single-agent bosutinib. The median durat
Eintrag öffnenBosulif · 4.8 · A total of 55 paediatric patients ≥ 1 year of age received at least 1 dose of bosutinib in the Phase I/II, mul
Eintrag öffnenBosulif · 4.8 · Among the 1 103 patients with diarrhoea, 218 patients (19.8%) were managed with treatment interruption and of
Eintrag öffnenBosulif · 4.8 · At least 1 adverse reaction of any toxicity grade was reported for 1,349 (98.3%) patients. The most frequent a
Eintrag öffnenBosulif · 4.8 · At least 1 adverse reaction of any toxicity grade was reported for 54 (98.2%) paediatric patients. The most fr
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