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Esbriet · 4.5 · Consumption of grapefruit juice is associated with inhibition of CYP1A2 and should be avoided during treatment
Eintrag öffnenEsbriet · 4.5 · Esbriet is contraindicated in patients with concomitant use of fluvoxamine (see section 4.3). Fluvoxamine shou
Eintrag öffnenEsbriet · 4.5 · Esbriet should be used with caution in patients treated with other moderate inhibitors of CYP1A2 (e.g. amiodar
Eintrag öffnenEsbriet · 4.5 · Fluvoxamine and inhibitors of CYP1A2
Eintrag öffnenEsbriet · 4.5 · In a Phase 1 study, the co-administration of Esbriet and fluvoxamine (a strong inhibitor of CYP1A2 with inhibi
Eintrag öffnenEsbriet · 4.5 · In the case of moderate inducers of CYP1A2 (e.g. omeprazole), concomitant use may theoretically result in a lo
Eintrag öffnenEsbriet · 4.5 · Special care should also be exercised if CYP1A2 inhibitors are being used concomitantly with potent inhibitors
Eintrag öffnenEsbriet · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenEsbriet · 4.8 Undesirable effects · 1
Eintrag öffnenEsbriet · 4.8 · 7 Table 1 Adverse reactions by SOC and MedDRA frequency Common Somnolence; dysgeusia; lethargy Vascular disord
Eintrag öffnenEsbriet · 4.8 · Decreased appetite During the pivotal clinical trials, cases of decreased appetite were readily manageable and
Eintrag öffnenEsbriet · 4.8 · Description of selected adverse reactions
Eintrag öffnenEsbriet · 4.8 · Exposure-adjusted analyses of pooled clinical trials in IPF confirmed that the safety and tolerability profile
Eintrag öffnenEsbriet · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenEsbriet · 4.8 · Summary of the safety profile The most frequently reported adverse reactions during clinical study experience
Eintrag öffnenEsbriet · 4.8 · Table 1 Adverse reactions by SOC and MedDRA frequency Infections and infestations Very Common Upper respirator
Eintrag öffnenEsbriet · 4.8 · Table 1 shows the adverse reactions reported at a frequency of ≥2% in 623 patients receiving Esbriet at the re
Eintrag öffnenEsbriet · 4.8 · Tabulated list of adverse reactions The safety of Esbriet has been evaluated in clinical studies including 1,6
Eintrag öffnenFimbrien, bakterielle
Eintrag öffnenFimbrienproteine
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