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Conexxence · 4.8 · Musculoskeletal pain Musculoskeletal pain, including severe cases, has been reported in patients receiving den
Eintrag öffnenConexxence · 4.8 · Osteonecrosis of the jaw ONJ has been reported rarely, in 16 patients, in clinical trials in osteoporosis and
Eintrag öffnenConexxence · 4.8 · Other special populations
Eintrag öffnenConexxence · 4.8 · Paediatric population Denosumab should not be used in paediatric patients (age < 18). Serious hypercalcaemia h
Eintrag öffnenConexxence · 4.8 · Renal impairment In clinical studies, patients with severe renal impairment (creatinine clearance < 30 mL/min)
Eintrag öffnenConexxence · 4.8 · Reporting of suspected adverse reactions
Eintrag öffnenConexxence · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenConexxence · 4.8 · Skin infections In phase III placebo-controlled clinical trials, the overall incidence of skin infections was
Eintrag öffnenConexxence · 4.8 · Summary of the safety profile
Eintrag öffnenConexxence · 4.8 · Tabulated list of adverse reactions
Eintrag öffnenConexxence · 4.8 · The data in table 1 below describe adverse reactions reported from phase II and III clinical trials in patient
Eintrag öffnenConexxence · 4.8 · The following convention has been used for the classification of the adverse reactions (see table 1): very com
Eintrag öffnenConexxence · 4.8 · The most common side effects with denosumab (seen in more than one patient in ten) are musculoskeletal pain an
Eintrag öffnenConexxence · 4.8 · The risk of ONJ has also been assessed in a retrospective cohort study among 76 192 postmenopausal women newly
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