Gezielt nachschlagen
Suche
Suche startet nach einer kurzen Eingabepause.
20 angezeigte Treffer · Seite 2, keine Gesamtzahl für „Cotellic“
Suchtreffer
Begriffe & Kennungen
Cotellic · 4.5 · Effects of cobimetinib on drug transport systems
Eintrag öffnenCotellic · 4.5 · Effects of cobimetinib on other medicinal products
Eintrag öffnenCotellic · 4.5 · Effects of other medicinal products on cobimetinib
Eintrag öffnenCotellic · 4.5 · In vitro studies show that cobimetinib is not a substrate of the liver uptake transporters OATP1B1, OATP1B3 an
Eintrag öffnenCotellic · 4.5 · In vitro, cobimetinib is a moderate inhibitor of BCRP (Breast Cancer Resistance Protein). No clinical DDI stud
Eintrag öffnenCotellic · 4.5 · In vitro, cobimetinib is a potential inducer of CYP1A2 and may therefore reduce the exposure of substrates of
Eintrag öffnenCotellic · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenCotellic · 4.5 · Mild CYP3A inhibitors
Eintrag öffnenCotellic · 4.5 · Moderate CYP3A inhibitors (see section 4.4.)
Eintrag öffnenCotellic · 4.5 · P-glycoprotein inhibitors
Eintrag öffnenCotellic · 4.5 · Paediatric population
Eintrag öffnenCotellic · 4.5 · There is no evidence of any clinically significant drug-drug interaction between cobimetinib and vemurafenib i
Eintrag öffnenCotellic · 4.5 · Vemurafenib
Eintrag öffnenCotellic · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenCotellic · 4.8 Undesirable effects · 1
Eintrag öffnenCotellic · 4.8 · 11 Table 3 Adverse drug reactions (ADRs) in patients treated with Cotellic in combination with vemurafenib in
Eintrag öffnenCotellic · 4.8 · 12 b Combined figure includes reports of photosensitivity reaction, sunburn, solar dermatitis, actinic elastos
Eintrag öffnenCotellic · 4.8 · 14 Renal impairment
Eintrag öffnenCotellic · 4.8 · ADR frequencies are based upon the safety analysis of patients treated with cobimetinib plus vemurafenib with
Eintrag öffnenCotellic · 4.8 · ADRs which were reported in melanoma patients are listed below by MedDRA body system organ class, frequency an
Eintrag öffnen