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Begriffe & Kennungen
Dovato · 4.5 · Darunavir Ritonavir (induction of UGT1A1 and CYP3A enzymes) Other antiviral active substances Daclatasvir/
Eintrag öffnenDovato · 4.5 · Darunavir Ritonavir Etravirine Efavirenz/Dolutegravir Dolutegravir The recommended dose of dolutegravi
Eintrag öffnenDovato · 4.5 · Dolutegravir is eliminated mainly through metabolism by uridine diphosphate glucuronosyl transferase (UGT) 1A1
Eintrag öffnenDovato · 4.5 · Effect of dolutegravir and lamivudine on the pharmacokinetics of other medicinal products
Eintrag öffnenDovato · 4.5 · Effect of other medicinal products on the pharmacokinetics of dolutegravir and lamivudine
Eintrag öffnenDovato · 4.5 · Established and theoretical interactions with selected antiretrovirals and non-antiretroviral medicinal produc
Eintrag öffnenDovato · 4.5 · In vitro, dolutegravir inhibited the renal transporters OCT2 and MATE1. In vivo, a 10-14% decrease of creatini
Eintrag öffnenDovato · 4.5 · In vitro, dolutegravir inhibited the renal uptake organic anion transporters (OAT)1 and OAT3. Based on the lac
Eintrag öffnenDovato · 4.5 · In vitro, lamivudine was an inhibitor of OCT1 and OCT2; the clinical consequences are not known.
Eintrag öffnenDovato · 4.5 · In vivo, dolutegravir did not have an effect on midazolam, a CYP3A4 probe. Based on in vivo and/or in vitro da
Eintrag öffnenDovato · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenDovato · 4.5 · Interactions between dolutegravir, lamivudine and co-administered medical products are listed in Table 1 (incr
Eintrag öffnenDovato · 4.5 · Lamivudine is cleared renally. Active renal secretion of lamivudine in the urine is mediated through the OCT2
Eintrag öffnenDovato · 4.5 · Lopinavir Ritonavir Darunavir+ritonavir/ Dolutegravir No dose adjustment is necessary. Dolutegravir AUC
Eintrag öffnenDovato · 4.5 · Lopinavir Ritonavir Etravirine Darunavir+ritonavir+etravirine/ Dolutegravir No dose adjustment is nece
Eintrag öffnenDovato · 4.5 · Medicinal products by Interaction geometric Recommendations concerning co- therapeutic areas mean change (%) a
Eintrag öffnenDovato · 4.5 · No drug interaction studies have been conducted using Dovato. Dovato contains dolutegravir and lamivudine, the
Eintrag öffnenDovato · 4.5 · Paediatric population
Eintrag öffnenDovato · 4.5 · Sulfamethoxazole: AUC
Eintrag öffnenDovato · 4.5 · Table 1: Drug Interactions
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