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Erleada · 4.5 · Apalutamide was shown to be a weak inducer of P-glycoprotein (P-gp), breast cancer resistance protein (BCRP),
Eintrag öffnenErleada · 4.5 · Based on in vitro data, inhibition of organic cation transporter 2 (OCT2), organic anion transporter 3 (OAT3)
Eintrag öffnenErleada · 4.5 · Based on in vitro data, inhibition of organic cation transporter 2 (OCT2), organic anion transporter 3 (OAT3)
Eintrag öffnenErleada · 4.5 · CYP2C8 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP2C8 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP3A4 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP3A4 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · Drug metabolising enzymes
Eintrag öffnenErleada · 4.5 · Drug metabolising enzymes
Eintrag öffnenErleada · 4.5 · Falsely elevated digoxin plasma level results with the chemiluminescent microparticle immunoassay (CMIA) have
Eintrag öffnenErleada · 4.5 · Falsely elevated digoxin plasma level results with the chemiluminescent microparticle immunoassay (CMIA) have
Eintrag öffnenErleada · 4.5 · GnRH Analogue
Eintrag öffnenErleada · 4.5 · GnRH Analogue
Eintrag öffnenErleada · 4.5 · In humans, apalutamide is a strong inducer of CYP3A4 and CYP2C19, and a weak inducer of CYP2C9. In a drug-drug
Eintrag öffnenErleada · 4.5 · In humans, apalutamide is a strong inducer of CYP3A4 and CYP2C19, and a weak inducer of CYP2C9. In a drug-drug
Eintrag öffnenErleada · 4.5 · In mHSPC subjects receiving leuprolide acetate (a GnRH analogue), co-administration with apalutamide had no ap
Eintrag öffnenErleada · 4.5 · In mHSPC subjects receiving leuprolide acetate (a GnRH analogue), co-administration with apalutamide had no ap
Eintrag öffnenErleada · 4.5 · In vitro studies showed that apalutamide and N-desmethyl apalutamide are moderate to strong CYP3A4 and CYP2B6
Eintrag öffnenErleada · 4.5 · In vitro studies showed that apalutamide and N-desmethyl apalutamide are moderate to strong CYP3A4 and CYP2B6
Eintrag öffnenErleada · 4.5 · Induction of CYP3A4 by apalutamide suggests that UDP-glucuronosyl transferase (UGT) may also be induced via ac
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