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Iscover · 4.5 · Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD) interaction i
Eintrag öffnenIscover · 4.5 · Inducers of CYP2C19 Since clopidogrel is metabolised to its active metabolite partly by CYP2C19, use of medici
Eintrag öffnenIscover · 4.5 · Inhibitors of CYP2C19 Since clopidogrel is metabolised to its active metabolite partly by CYP2C19, use of medi
Eintrag öffnenIscover · 4.5 · Less pronounced reductions of metabolite exposure has been observed with pantoprazole or lansoprazole. The pla
Eintrag öffnenIscover · 4.5 · Medicinal products associated with bleeding risk: There is an increased risk of bleeding due to the potential
Eintrag öffnenIscover · 4.5 · Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomepr
Eintrag öffnenIscover · 4.5 · NSAIDs: in a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and
Eintrag öffnenIscover · 4.5 · Oral anticoagulants: the concomitant administration of clopidogrel with oral anticoagulants is not recommended
Eintrag öffnenIscover · 4.5 · Other concomitant therapy:
Eintrag öffnenIscover · 4.5 · Other medicinal products: A number of other clinical studies have been conducted with clopidogrel and other co
Eintrag öffnenIscover · 4.5 · Proton Pump Inhibitors (PPI): Omeprazole 80 mg once daily administered either at the same time as clopidogrel
Eintrag öffnenIscover · 4.5 · Rifampicin strongly induces CYP2C19, resulting in both an increased level of clopidogrel active
Eintrag öffnenIscover · 4.5 · Rosuvastatin: Clopidogrel has been shown to increase rosuvastatin exposure in patients by 2-fold (AUC) and 1.3
Eintrag öffnenIscover · 4.5 · SSRIs: since SSRIs affect platelet activation and increase the risk of bleeding, the concomitant administratio
Eintrag öffnenIscover · 4.5 · The pharmacokinetics of digoxin or theophylline were not modified by the co-administration of clopidogrel. Ant
Eintrag öffnenIscover · 4.5 · There is no evidence that other medicinal products that reduce stomach acid such as H2 blockers or antacids in
Eintrag öffnenIscover · 4.5 · Thrombolytics: the safety of the concomitant administration of clopidogrel, fibrin or non-fibrin specific thro
Eintrag öffnenIscover · 4.5 · metabolite and platelet inhibition, which in particular might potentiate the risk of bleeding. As a precaution
Eintrag öffnenIscover · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenIscover · 4.8 Undesirable effects · 1
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