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Ivemend · 4.5 · Midazolam Fosaprepitant 150 mg administered as a single intravenous dose on Day 1 increased the AUC0-∞ of mida
Eintrag öffnenIvemend · 4.5 · Paediatric population Interaction studies have only been performed in adults.
Eintrag öffnenIvemend · 4.5 · The following information was derived from studies conducted with oral aprepitant and studies conducted with i
Eintrag öffnenIvemend · 4.5 · The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolised via
Eintrag öffnenIvemend · 4.5 · Warfarin In patients on chronic warfarin therapy, the prothrombin time (INR) should be monitored closely durin
Eintrag öffnenIvemend · 4.5 · When administered intravenously fosaprepitant is rapidly converted to aprepitant.
Eintrag öffnenIvemend · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenIvemend · 4.8 Undesirable effects · 1
Eintrag öffnenIvemend · 4.8 · 10 System organ class Adverse reaction Frequency Cardiac disorders palpitations uncommon bradycardia, cardiova
Eintrag öffnenIvemend · 4.8 · 11 patients receiving MEC, safety was evaluated for 504 patients receiving a single dose of IVEMEND 150 mg com
Eintrag öffnenIvemend · 4.8 · Blood and lymphatic system febrile neutropenia, anaemia uncommon disorders
Eintrag öffnenIvemend · 4.8 · Description of selected adverse reactions The adverse reactions profiles in the Multiple-Cycle extension of HE
Eintrag öffnenIvemend · 4.8 · Fosaprepitant In an active-controlled clinical study in adult patients receiving HEC, safety was evaluated for
Eintrag öffnenIvemend · 4.8 · Frequencies are defined as: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare
Eintrag öffnenIvemend · 4.8 · Immune system disorders hypersensitivity reactions including not known anaphylactic reactions Metabolism and n
Eintrag öffnenIvemend · 4.8 · In an additional active-controlled clinical study in 1,169 adult patients receiving aprepitant and HEC, the ad
Eintrag öffnenIvemend · 4.8 · Non-CINV studies Additional adverse reactions were observed in adult patients treated with aprepitant for post
Eintrag öffnenIvemend · 4.8 · Oral aprepitant The most common adverse reactions reported at a greater incidence in adults treated with the a
Eintrag öffnenIvemend · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenIvemend · 4.8 · Summary of the safety profile In clinical studies, various formulations of fosaprepitant have been administere
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