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Jemperli · 4.8 · Elderly population
Eintrag öffnenJemperli · 4.8 · Hyperthyroidism occurred in 14 (2.3 %) patients, including grade 2 (2.1 %) and grade 3 (0.2 %). Hyperthyroidis
Eintrag öffnenJemperli · 4.8 · Immune checkpoint inhibitor class effects
Eintrag öffnenJemperli · 4.8 · Immune-mediated endocrinopathies Hypothyroidism occurred in 46 (7.6 %) patients, all of which were grade 2. Hy
Eintrag öffnenJemperli · 4.8 · Immune-mediated nephritis Nephritis, including tubulointerstitial nephritis, occurred in 3 (0.5 %) patients; a
Eintrag öffnenJemperli · 4.8 · Immune-related adverse reactions (see section 4.4)
Eintrag öffnenJemperli · 4.8 · Immune-related arthralgia Immune-related arthralgia occurred in 34 (5.6 %) patients. Grade 3 immune-related ar
Eintrag öffnenJemperli · 4.8 · Immune-related colitis Colitis occurred in 8 (1.3 %) patients, including grade 2 (0.7 %) and grade 3 (0.7 %) c
Eintrag öffnenJemperli · 4.8 · Immune-related hepatitis Hepatitis occurred in 3 (0.5 %) patients, all of which were grade 3. Systemic cortico
Eintrag öffnenJemperli · 4.8 · Immune-related pneumonitis Immune-related pneumonitis occurred in 14 (2.3 %) patients, including grade 2 (1.3
Eintrag öffnenJemperli · 4.8 · Immune-related rash Immune-related rash (rash, rash maculo-papular, rash macular, rash pruritic, pemphigoid, d
Eintrag öffnenJemperli · 4.8 · Immunogenicity
Eintrag öffnenJemperli · 4.8 · In patients with advanced or recurrent solid tumours (N = 605), the most common adverse reactions (> 10 %) wer
Eintrag öffnenJemperli · 4.8 · In patients with primary advanced or recurrent EC (N = 241), the most common adverse reactions (≥ 10 %) were r
Eintrag öffnenJemperli · 4.8 · In the GARNET study, anti-drug antibodies (ADA) were tested in 315 patients who received dostarlimab and the i
Eintrag öffnenJemperli · 4.8 · In the patients who developed ADAs, there was no evidence of altered efficacy or safety of dostarlimab.
Eintrag öffnenJemperli · 4.8 · Infusion-related reactions Infusion-related reactions including hypersensitivity occurred in 6 (1.0 %) patient
Eintrag öffnenJemperli · 4.8 · Of the 605 patients treated with dostarlimab monotherapy, 51.6 % were under 65 years, 36.9 % were 65 to less t
Eintrag öffnenJemperli · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenJemperli · 4.8 · Summary of the safety profile
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