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Jentadueto · 4.5 · Oral contraceptives: Co-administration with 5 mg linagliptin did not alter the steady-state pharmacokinetics o
Eintrag öffnenJentadueto · 4.5 · Rifampicin: Multiple co-administration of 5 mg linagliptin with rifampicin, a potent inductor of P-glycoprotei
Eintrag öffnenJentadueto · 4.5 · Ritonavir: Co-administration of a single 5 mg oral dose of linagliptin and multiple 200 mg oral doses of riton
Eintrag öffnenJentadueto · 4.5 · Simvastatin: Multiple daily doses of linagliptin had a minimal effect on the steady-state pharmacokinetics of
Eintrag öffnenJentadueto · 4.5 · Some medicinal products can adversely affect renal function which may increase the risk of lactic acidosis, e.
Eintrag öffnenJentadueto · 4.5 · Sulphonylureas: Co-administration of multiple oral doses of 5 mg linagliptin and a single oral dose of 1.75 mg
Eintrag öffnenJentadueto · 4.5 · Sulphonylureas: The steady-state pharmacokinetics of 5 mg linagliptin were not changed by concomitant administ
Eintrag öffnenJentadueto · 4.5 · Warfarin: Multiple daily doses of 5 mg linagliptin did not alter the pharmacokinetics of S(-) or R(+) warfarin
Eintrag öffnenJentadueto · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenJentadueto · 4.8 Undesirable effects · 1
Eintrag öffnenJentadueto · 4.8 · 10 receiving placebo. Safety data from this study was in line with previous known safety profile of linaglipti
Eintrag öffnenJentadueto · 4.8 · 9 System organ class Frequency of adverse reaction Adverse reaction Infections and infestations Nasopharyngiti
Eintrag öffnenJentadueto · 4.8 · Description of selected adverse reactions Hypoglycaemia In one study linagliptin was given as add-on to metfor
Eintrag öffnenJentadueto · 4.8 · Hypoglycaemia may occur when Jentadueto is administered together with sulphonylurea (≥ 1 case per 10 patients)
Eintrag öffnenJentadueto · 4.8 · In the CARMELINA study, bullous pemphigoid was reported in 0.2% of patients treated with linagliptin and in no
Eintrag öffnenJentadueto · 4.8 · In the overall study observation period adjudicated acute pancreatitis was reported in 0.3% of patients treate
Eintrag öffnenJentadueto · 4.8 · In the pooled analysis of the seven placebo-controlled trials, the overall incidence of adverse events in pati
Eintrag öffnenJentadueto · 4.8 · In the treated population, severe hypoglycaemic events (requiring assistance) were reported in 3.0% of patient
Eintrag öffnenJentadueto · 4.8 · Linagliptin cardiovascular and renal safety study (CARMELINA) The CARMELINA study evaluated the cardiovascular
Eintrag öffnenJentadueto · 4.8 · Other adverse reactions Gastrointestinal disorders such as, nausea, vomiting, diarrhoea and decreased appetite
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