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Kalydeco · 4.5 · CYP3A substrates
Eintrag öffnenKalydeco · 4.5 · CYP3A substrates
Eintrag öffnenKalydeco · 4.5 · Ciprofloxacin
Eintrag öffnenKalydeco · 4.5 · Ciprofloxacin
Eintrag öffnenKalydeco · 4.5 · Co-administration of ciprofloxacin with ivacaftor did not affect the exposure of ivacaftor. No dose adjustment
Eintrag öffnenKalydeco · 4.5 · Co-administration of ciprofloxacin with ivacaftor did not affect the exposure of ivacaftor. No dose adjustment
Eintrag öffnenKalydeco · 4.5 · Co-administration of ivacaftor with grapefruit juice, which contains one or more components that moderately in
Eintrag öffnenKalydeco · 4.5 · Co-administration of ivacaftor with grapefruit juice, which contains one or more components that moderately in
Eintrag öffnenKalydeco · 4.5 · Co-administration of ivacaftor with rifampicin, a strong CYP3A inducer, decreased ivacaftor exposure (AUC) by
Eintrag öffnenKalydeco · 4.5 · Co-administration of ivacaftor with rifampicin, a strong CYP3A inducer, decreased ivacaftor exposure (AUC) by
Eintrag öffnenKalydeco · 4.5 · Co-administration with (oral) midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, c
Eintrag öffnenKalydeco · 4.5 · Co-administration with (oral) midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, c
Eintrag öffnenKalydeco · 4.5 · Co-administration with digoxin, a sensitive P-gp substrate, increased digoxin exposure by 1.3-fold, consistent
Eintrag öffnenKalydeco · 4.5 · Co-administration with digoxin, a sensitive P-gp substrate, increased digoxin exposure by 1.3-fold, consistent
Eintrag öffnenKalydeco · 4.5 · Co-administration with fluconazole, a moderate inhibitor of CYP3A, increased ivacaftor exposure by 3-fold and
Eintrag öffnenKalydeco · 4.5 · Digoxin and other P-gp substrates
Eintrag öffnenKalydeco · 4.5 · Digoxin and other P-gp substrates
Eintrag öffnenKalydeco · 4.5 · Hormonal contraceptives
Eintrag öffnenKalydeco · 4.5 · Hormonal contraceptives
Eintrag öffnenKalydeco · 4.5 · In vitro studies showed that ivacaftor is not a substrate for OATP1B1 or OATP1B3. Ivacaftor and its metabolite
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