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Krazati · 4.5 · Transporter systems
Eintrag öffnenKrazati · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenKrazati · 4.8 Undesirable effects · 1
Eintrag öffnenKrazati · 4.8 · 7 Table 3: Adverse reactions reported in patients treated with adagrasib
Eintrag öffnenKrazati · 4.8 · 8 Hepatotoxicity Hepatotoxicity-related reactions were reported in 41.0% (all grades) and 11.3% (Grade ≥ 3) of
Eintrag öffnenKrazati · 4.8 · 9 Reporting of suspected adverse reactions
Eintrag öffnenKrazati · 4.8 · Adverse reaction frequency estimates are derived from 821 patients exposed at adagrasib 600 mg twice-daily for
Eintrag öffnenKrazati · 4.8 · Adverse reactions leading to treatment discontinuation are pneumonitis (< 1%), nausea (< 1%), fatigue (< 1%),
Eintrag öffnenKrazati · 4.8 · Adverse reactions reported in clinical studies are listed by system organ class, preferred terms and by freque
Eintrag öffnenKrazati · 4.8 · All subjects treated with adagrasib 600 mg twice daily in clinical studies N = 821 System organ class Frequenc
Eintrag öffnenKrazati · 4.8 · Anaemia Anaemia of any grade was reported in 32.4% of patients, with 7.2% of patients with grade ≥ 3 events. M
Eintrag öffnenKrazati · 4.8 · Blood creatinine increased led to dose reduction or interruption in 6.9% of patients. Blood creatinine increas
Eintrag öffnenKrazati · 4.8 · Description of selected adverse reactions
Eintrag öffnenKrazati · 4.8 · Diarrhoea, nausea and vomiting resulted in dose interruption or reduction in 13.3%, 14.7% and 13.4% of patient
Eintrag öffnenKrazati · 4.8 · Elderly Adagrasib has been studied in 396 patients aged ≥ 65-year-old. When compared to those < 65 years, no c
Eintrag öffnenKrazati · 4.8 · Elevations of ALT resulted in dose interruption and/or reduction in 10.2% of patients, and elevations of AST r
Eintrag öffnenKrazati · 4.8 · Frequencies are defined as: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1 000 to < 1/100);
Eintrag öffnenKrazati · 4.8 · Gastrointestinal adverse reactions Gastrointestinal (GI) adverse reactions occur in 85.3% of patients taking a
Eintrag öffnenKrazati · 4.8 · Hyponatraemia Hyponatraemia was reported in 17.1% (all grades) and 4.0% (grade ≥ 3) of patients treated with a
Eintrag öffnenKrazati · 4.8 · Increased blood creatinine Increased blood creatinine of any grade was reported 31.7% of patients, with < 1% o
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