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Leflunomide ratiopharm · 4.5 · Effect on BCRP (Breast Cancer Resistance Protein) and /or organic anion transporting polypeptide B1 and B3 (OA
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on caffeine (CYP1A2 substrate) Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on oral contraceptive (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) There was an increase in me
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on repaglinide (CYP2C8 substrate) There was an increase in mean repaglinide Cmax and AUC (1.7- and 2.4-
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Effect on warfarin (CYP2C9 substrate) Repeated doses of A771726 had no effect on the pharmacokinetics of S-war
Eintrag öffnenLeflunomide ratiopharm · 4.5 · If the patient is already receiving nonsteroidal anti-inflammatory drugs (NSAIDs) and/or corticosteroids, thes
Eintrag öffnenLeflunomide ratiopharm · 4.5 · In a small (n=30) study with co-administration of leflunomide (10 to 20 mg per day) with methotrexate (10 to 2
Eintrag öffnenLeflunomide ratiopharm · 4.5 · In a study in which leflunomide was given concomitantly with a triphasic oral contraceptive pill containing 30
Eintrag öffnenLeflunomide ratiopharm · 4.5 · In patients with rheumatoid arthritis, no pharmacokinetic interaction between the leflunomide (10 to 20 mg per
Eintrag öffnenLeflunomide ratiopharm · 4.5 · In vitro inhibition studies in human liver microsomes suggest that cytochrome P450 (CYP) 1A2, 2C19 and 3A4 are
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Interactions studies have only been performed in adults.
Eintrag öffnenLeflunomide ratiopharm · 4.5 · It is recommended that patients receiving leflunomide are not treated with colestyramine or activated powdered
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Methotrexate
Eintrag öffnenLeflunomide ratiopharm · 4.5 · NSAIDS/Corticosteroids
Eintrag öffnenLeflunomide ratiopharm · 4.5 · No clinical data are available on the efficacy and safety of vaccinations under leflunomide treatment. Vaccina
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Oral contraceptives
Eintrag öffnenLeflunomide ratiopharm · 4.5 · The following pharmacokinetic and pharmacodynamic interaction studies were conducted with A771726 (principal a
Eintrag öffnenLeflunomide ratiopharm · 4.5 · There have been case reports of increased prothrombin time, when leflunomide and warfarin were co-administered
Eintrag öffnenLeflunomide ratiopharm · 4.5 · Vaccinations
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