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Lixiana · 4.5 · Edoxaban 30 mg once daily must be administered during concomitant use with the following P-gp inhibitors: • Ci
Eintrag öffnenLixiana · 4.5 · Edoxaban decreased the Cmax and AUC of concomitantly administered verapamil by 14% and 16%, respectively.
Eintrag öffnenLixiana · 4.5 · Edoxaban increased the Cmax of concomitantly administered digoxin by 28%; however, the AUC was not affected. E
Eintrag öffnenLixiana · 4.5 · Edoxaban is a substrate for the efflux transporter P-gp. In pharmacokinetic (PK) studies, concomitant administ
Eintrag öffnenLixiana · 4.5 · Edoxaban is predominantly absorbed in the upper gastrointestinal (GI) tract. Thus, medicinal products or disea
Eintrag öffnenLixiana · 4.5 · Effect of edoxaban on other medicinal products
Eintrag öffnenLixiana · 4.5 · In clinical studies concomitant use of ASA (low dose ≤ 100 mg/day), other antiplatelet agents, and thienopyrid
Eintrag öffnenLixiana · 4.5 · NSAIDs Co-administration of naproxen and edoxaban increased bleeding time relative to either medicinal product
Eintrag öffnenLixiana · 4.5 · P-gp inducers
Eintrag öffnenLixiana · 4.5 · P-gp inhibitors
Eintrag öffnenLixiana · 4.5 · P-gp substrates
Eintrag öffnenLixiana · 4.5 · Platelet inhibitors In ENGAGE AF-TIMI 48 concomitant use of thienopyridines (e.g. clopidogrel) monotherapy was
Eintrag öffnenLixiana · 4.5 · SSRIs/SNRIs As with other anticoagulants the possibility may exist that patients are at increased risk of blee
Eintrag öffnenLixiana · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenLixiana · 4.8 Undesirable effects · 1
Eintrag öffnenLixiana · 4.8 · 12 The most commonly reported adverse reactions associated with edoxaban treatment are epistaxis (7.7%), haema
Eintrag öffnenLixiana · 4.8 · 13 System organ class Frequency Transaminases increased Uncommon Skin and subcutaneous tissue disorders Cutane
Eintrag öffnenLixiana · 4.8 · 14 145 patients treated with edoxaban) and cardiac diseases at risk of thrombotic events (167 patients, 109 pa
Eintrag öffnenLixiana · 4.8 · Bleeding can occur at any site and may be severe and even fatal (see section 4.4).
Eintrag öffnenLixiana · 4.8 · Description of selected adverse reactions
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