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Mekinist · 4.8 · 12 The safety of trametinib in combination with dabrafenib has been evaluated in the integrated safety populat
Eintrag öffnenMekinist · 4.8 · 13 Hypertension Very common Vascular disorders Haemorrhagec Common Lymphoedema Cough Very common Respiratory,
Eintrag öffnenMekinist · 4.8 · 14 Table 5 Adverse reactions with trametinib in combination with dabrafenib
Eintrag öffnenMekinist · 4.8 · 15 Abdominal paing Constipation Very common Diarrhoea Nausea Vomiting Gastrointestinal disorders Dry mouth Com
Eintrag öffnenMekinist · 4.8 · 16 Injury, poisoning and Common Potentiation of radiation toxicity procedural complications a Cutaneous squamo
Eintrag öffnenMekinist · 4.8 · 17 treatment with trametinib monotherapy or in combination with dabrafenib have liver function monitored every
Eintrag öffnenMekinist · 4.8 · 18 and increased creatine phosphokinase. Two adolescent patients experienced an asymptomatic decrease of more
Eintrag öffnenMekinist · 4.8 · Adverse reactions are listed below by MedDRA system organ class. The following convention has been utilised fo
Eintrag öffnenMekinist · 4.8 · Adverse reactions associated with trametinib obtained from clinical studies and post-marketing surveillance ar
Eintrag öffnenMekinist · 4.8 · Description of selected adverse reactions
Eintrag öffnenMekinist · 4.8 · Disorders associated with visual disturbances, including RPED and RVO, have been observed with trametinib. Sym
Eintrag öffnenMekinist · 4.8 · Elevations in blood pressure have been reported in association with trametinib as monotherapy and in combinati
Eintrag öffnenMekinist · 4.8 · Haemorrhage
Eintrag öffnenMekinist · 4.8 · Haemorrhagic events, including major haemorrhagic events and fatal haemorrhages, occurred in patients taking t
Eintrag öffnenMekinist · 4.8 · Hepatic adverse reactions have been reported in clinical studies with trametinib as monotherapy and in combina
Eintrag öffnenMekinist · 4.8 · Hepatic events
Eintrag öffnenMekinist · 4.8 · Hepatic impairment
Eintrag öffnenMekinist · 4.8 · Hypertension
Eintrag öffnenMekinist · 4.8 · In clinical studies in other indications, the safety profile of trametinib in combination with dabrafenib in p
Eintrag öffnenMekinist · 4.8 · In the Phase III study with trametinib in patients with unresectable or metastatic melanoma (n=211), 49 patien
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