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Neparvis · 4.5 · Interactions requiring precautions
Eintrag öffnenNeparvis · 4.5 · Interactions resulting in a contraindication
Eintrag öffnenNeparvis · 4.5 · Interactions resulting in a contraindication
Eintrag öffnenNeparvis · 4.5 · Interactions resulting in concomitant use not being recommended
Eintrag öffnenNeparvis · 4.5 · Interactions resulting in concomitant use not being recommended
Eintrag öffnenNeparvis · 4.5 · Lithium Reversible increases in serum lithium concentrations and toxicity have been reported during concomitan
Eintrag öffnenNeparvis · 4.5 · Lithium Reversible increases in serum lithium concentrations and toxicity have been reported during concomitan
Eintrag öffnenNeparvis · 4.5 · Metformin Co-administration of sacubitril/valsartan with metformin reduced both Cmax and AUC of metformin by 2
Eintrag öffnenNeparvis · 4.5 · Metformin Co-administration of sacubitril/valsartan with metformin reduced both Cmax and AUC of metformin by 2
Eintrag öffnenNeparvis · 4.5 · Nitrates, e.g. nitroglycerine There was no interaction between sacubitril/valsartan and intravenously administ
Eintrag öffnenNeparvis · 4.5 · Nitrates, e.g. nitroglycerine There was no interaction between sacubitril/valsartan and intravenously administ
Eintrag öffnenNeparvis · 4.5 · No clinically meaningful interaction was observed when sacubitril/valsartan was co-administered with digoxin,
Eintrag öffnenNeparvis · 4.5 · No clinically meaningful interaction was observed when sacubitril/valsartan was co-administered with digoxin,
Eintrag öffnenNeparvis · 4.5 · No significant interaction
Eintrag öffnenNeparvis · 4.5 · No significant interaction
Eintrag öffnenNeparvis · 4.5 · Non-steroidal anti-inflammatory agents (NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors In el
Eintrag öffnenNeparvis · 4.5 · Non-steroidal anti-inflammatory agents (NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors In el
Eintrag öffnenNeparvis · 4.5 · OATP and MRP2 transporters The active metabolite of sacubitril (LBQ657) and valsartan are OATP1B1, OATP1B3, OA
Eintrag öffnenNeparvis · 4.5 · OATP and MRP2 transporters The active metabolite of sacubitril (LBQ657) and valsartan are OATP1B1, OATP1B3, OA
Eintrag öffnenNeparvis · 4.5 · OATP1B1 and OATP1B3 substrates, e.g. statins In vitro data indicate that sacubitril inhibits OATP1B1 and OATP1
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